{"id":"https://openalex.org/W2008018710","doi":"https://doi.org/10.1055/s-0031-1276076","title":"Effects of transdermal estrogen administration on peripheral vascular responsiveness in menopausal women","display_name":"Effects of transdermal estrogen administration on peripheral vascular responsiveness in menopausal women","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2008018710","doi":"https://doi.org/10.1055/s-0031-1276076","mag":"2008018710"},"language":"en","primary_location":{"id":"doi:10.1055/s-0031-1276076","doi":"https://doi.org/10.1055/s-0031-1276076","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1276076","pdf_url":null,"source":{"id":"https://openalex.org/S107681283","display_name":"International Journal of Angiology","issn_l":"1061-1711","issn":["1061-1711","1615-5939"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Angiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/741444","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063604293","display_name":"Giuseppe Mercuro","orcid":"https://orcid.org/0000-0003-0097-2152","observed_orcids":["https://orcid.org/0000-0003-0097-2152"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Mercuro","raw_affiliation_strings":["Institute of Cardiology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049373401","display_name":"Carlo Balloi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Balloi","raw_affiliation_strings":["Institute of Cardiology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045864141","display_name":"Gianfranco De Candia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianfranco De Candia","raw_affiliation_strings":["Institute of Cardiology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036796010","display_name":"M. Panzuto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Panzuto","raw_affiliation_strings":["Institute of Cardiology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038159111","display_name":"Sandra Zoncu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandra Zoncu","raw_affiliation_strings":["Institute of Cardiology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057760557","display_name":"Angelo Cagnacci","orcid":"https://orcid.org/0000-0003-2714-623X","observed_orcids":["https://orcid.org/0000-0003-2714-623X"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Cagnacci","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045022871","display_name":"Gian Benedetto Melis","orcid":"https://orcid.org/0000-0002-2260-9277","observed_orcids":["https://orcid.org/0000-0002-2260-9277"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian Melis","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111840969","display_name":"Angelo Cherchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Cherchi","raw_affiliation_strings":["Institute of Cardiology, University of Cagliari, Sardinia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiology, University of Cagliari, Sardinia, Italy","institution_ids":["https://openalex.org/I172446870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I172446870"],"apc_list":null,"apc_paid":null,"fwci":0.8517,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71448077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"04","first_page":"237","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-estradiol","display_name":"transdermal estradiol","score":0.9079999923706055},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.7250000238418579},{"id":"https://openalex.org/keywords/peripheral-vascular-response","display_name":"peripheral vascular response","score":0.6430000066757202},{"id":"https://openalex.org/keywords/forearm-blood-flow","display_name":"forearm blood flow","score":0.9240000247955322},{"id":"https://openalex.org/keywords/vascular-resistance","display_name":"vascular resistance","score":0.796999990940094},{"id":"https://openalex.org/keywords/venous-compliance","display_name":"venous compliance","score":0.9729999899864197},{"id":"https://openalex.org/keywords/venous-volume","display_name":"venous volume","score":0.8849999904632568},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/estrogen-replacement-therapy","display_name":"estrogen replacement therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9092685580253601},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5393611788749695},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5192273259162903},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5113584399223328},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.500751256942749},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48157644271850586},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.46945399045944214},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.4538513422012329},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4537222683429718},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4375329315662384},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3613121509552002},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.09957948327064514},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.07624253630638123}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0031-1276076","doi":"https://doi.org/10.1055/s-0031-1276076","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1276076","pdf_url":null,"source":{"id":"https://openalex.org/S107681283","display_name":"International Journal of Angiology","issn_l":"1061-1711","issn":["1061-1711","1615-5939"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Angiology","raw_type":"journal-article"},{"id":"doi:10.1007/bf01616220","doi":"https://doi.org/10.1007/bf01616220","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01616220","pdf_url":null,"source":{"id":"https://openalex.org/S107681283","display_name":"International Journal of Angiology","issn_l":"1061-1711","issn":["1061-1711","1615-5939"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Angiology","raw_type":"journal-article"},{"id":"pmh:oai:iris.unimore.it:11380/741444","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/741444","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/741444","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/741444","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W138085915","https://openalex.org/W161179161","https://openalex.org/W1966954828","https://openalex.org/W1968162659","https://openalex.org/W1980868004","https://openalex.org/W1987144846","https://openalex.org/W1990024629","https://openalex.org/W1990304990","https://openalex.org/W2000683907","https://openalex.org/W2005520585","https://openalex.org/W2014236193","https://openalex.org/W2022368044","https://openalex.org/W2064772944","https://openalex.org/W2075044057","https://openalex.org/W2079274039","https://openalex.org/W2089922885","https://openalex.org/W2094588318","https://openalex.org/W2120955256","https://openalex.org/W2154519603","https://openalex.org/W2227292976","https://openalex.org/W2233668517","https://openalex.org/W2418508288","https://openalex.org/W2427307380","https://openalex.org/W2464462415","https://openalex.org/W2972867833","https://openalex.org/W3124994028","https://openalex.org/W4294294184"],"related_works":["https://openalex.org/W2054153594","https://openalex.org/W2024004607","https://openalex.org/W2321820300","https://openalex.org/W2076389409","https://openalex.org/W2053727048","https://openalex.org/W6990665379","https://openalex.org/W1970132710","https://openalex.org/W2056190041","https://openalex.org/W2093124769","https://openalex.org/W2154909037"],"abstract_inverted_index":{"This":[0],"study":[1,19],"was":[2,55,110],"designed":[3],"to":[4,10,15,31,42,57,162],"evaluate":[5],"the":[6,100],"peripheral":[7,157,183],"vascular":[8,80,125],"responses":[9],"acute":[11],"estrogen":[12,53,154,181],"replacement.":[13],"According":[14],"a":[16,59,163,178],"cross-over,":[17],"double-blind":[18],"design,":[20],"we":[21],"randomized":[22],"nine":[23],"healthy":[24],"postmenopausal":[25],"women":[26],"(time":[27],"lapse":[28],"from":[29],"menopause":[30],">1":[32],"year;":[33],"mean":[34,139],"age":[35],"\u00b1":[36,39],"SD":[37],"45.4":[38],"11.7":[40],"years)":[41],"treatment":[43],"with":[44],"transdermal":[45],"patches":[46],"of":[47,62,64,72,107,166,180],"estradiol-17\u03b2":[48,167],"or":[49,142],"matched":[50],"placebo.":[51],"The":[52,127,156],"patch":[54],"rated":[56],"assure":[58],"plasma":[60],"concentration":[61,106],"substance":[63],"more":[65],"than":[66],"100":[67],"pg/ml":[68],"after":[69],"8\u201310":[70],"hours":[71],"treatment.":[73],"Forearm":[74],"blood":[75,119],"flow":[76,120],"(ml/100":[77,86,91],"ml/minute),":[78,83],"local":[79,124],"resistance":[81],"(mmHg/ml/100":[82],"venous":[84,89,102,148,171],"volume":[85,146],"ml),":[87],"and":[88,121,147,170,173],"compliance":[90,149],"ml/mmHg)":[92],"were":[93,134,150],"measured":[94],"in":[95,117,123,138,175],"supine":[96],"resting":[97],"subjects":[98],"by":[99,112,153],"straingauge":[101],"occlusion":[103],"plethysmography.":[104],"Plasma":[105],"norepinephrine":[108,131],"(pg/ml)":[109],"quantified":[111],"HPLC-ED.":[113],"Estradiol-17\u03b2":[114],"produced":[115],"increase":[116],"forearm":[118],"decrease":[122],"resistance.":[126],"drug":[128],"reduced":[129],"circulating":[130],"concentrations.":[132],"There":[133],"no":[135],"significant":[136],"changes":[137,159],"arterial":[140,169],"pressure":[141],"heart":[143],"rate.":[144],"Venous":[145],"both":[151],"enhanced":[152],"administration.":[155],"circulatory":[158],"are":[160],"attributed":[161],"direct":[164],"activity":[165],"on":[168,182],"wall":[172],"may":[174],"part":[176],"reflect":[177],"modulation":[179],"sympathetic":[184],"tone.":[185]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
