{"id":"https://openalex.org/W2008012306","doi":"https://doi.org/10.1210/en.138.12.5352","title":"Maternal Growth Hormone Treatment Increases Placental Diffusion Capacity But Not Fetal or Placental Growth in Sheep","display_name":"Maternal Growth Hormone Treatment Increases Placental Diffusion Capacity But Not Fetal or Placental Growth in Sheep","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2008012306","doi":"https://doi.org/10.1210/en.138.12.5352","mag":"2008012306","pmid":"https://pubmed.ncbi.nlm.nih.gov/9389520"},"language":"en","primary_location":{"id":"doi:10.1210/en.138.12.5352","doi":"https://doi.org/10.1210/en.138.12.5352","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.138.12.5352","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023252382","display_name":"Jane Elizabeth Harding","orcid":"https://orcid.org/0000-0003-2697-1422","observed_orcids":["https://orcid.org/0000-0003-2697-1422"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"J. E. Harding","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111461909","display_name":"Pandora C. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"P. C. Evans","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058979039","display_name":"Peter David Gluckman","orcid":"https://orcid.org/0000-0002-5711-1655","observed_orcids":["https://orcid.org/0000-0002-5711-1655"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"P. D. Gluckman","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.643,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.82514948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"138","issue":"12","first_page":"5352","last_page":"5358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-growth","display_name":"fetal growth","score":0.8830000162124634},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8730000257492065},{"id":"https://openalex.org/keywords/placental-transport","display_name":"placental transport","score":0.8220000267028809},{"id":"https://openalex.org/keywords/blood-urea","display_name":"blood urea","score":0.8180000185966492},{"id":"https://openalex.org/keywords/maternal-diet","display_name":"maternal diet","score":0.890999972820282},{"id":"https://openalex.org/keywords/sheep-pregnancy","display_name":"sheep pregnancy","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8391939401626587},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.824796199798584},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.823969304561615},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.5974276065826416},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5303010940551758},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5042206048965454},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.48777276277542114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47307902574539185},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.45481976866722107},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.45077937841415405},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.288738876581192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2861347794532776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06783118844032288},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010928","descriptor_name":"Placental Lactogen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010929","descriptor_name":"Placentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.138.12.5352","doi":"https://doi.org/10.1210/en.138.12.5352","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.138.12.5352","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.138.12.5584","doi":"https://doi.org/10.1210/endo.138.12.5584","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.138.12.5584","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:9389520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9389520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5149999856948853}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320776","display_name":"Auckland Medical Research Foundation","ror":"https://ror.org/05wtegv53"},{"id":"https://openalex.org/F4320334749","display_name":"Health Research Council of New Zealand","ror":"https://ror.org/00zbf3d93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W625720590","https://openalex.org/W1663246079","https://openalex.org/W1752232811","https://openalex.org/W1966609305","https://openalex.org/W1969204732","https://openalex.org/W1978094930","https://openalex.org/W1979784084","https://openalex.org/W1980200927","https://openalex.org/W1984510069","https://openalex.org/W1991661759","https://openalex.org/W1993672117","https://openalex.org/W2002795919","https://openalex.org/W2002997708","https://openalex.org/W2003546164","https://openalex.org/W2012092999","https://openalex.org/W2018377561","https://openalex.org/W2026009764","https://openalex.org/W2027241991","https://openalex.org/W2028136880","https://openalex.org/W2036482185","https://openalex.org/W2039825798","https://openalex.org/W2045840874","https://openalex.org/W2055027427","https://openalex.org/W2065767384","https://openalex.org/W2068923375","https://openalex.org/W2070705717","https://openalex.org/W2070971135","https://openalex.org/W2076606453","https://openalex.org/W2078747462","https://openalex.org/W2079215552","https://openalex.org/W2080162877","https://openalex.org/W2082786291","https://openalex.org/W2089990471","https://openalex.org/W2320296534","https://openalex.org/W2341657917","https://openalex.org/W2409053884","https://openalex.org/W2410313666","https://openalex.org/W2566899071"],"related_works":["https://openalex.org/W2154688133","https://openalex.org/W2100520738","https://openalex.org/W587701953","https://openalex.org/W2155931214","https://openalex.org/W2028136880","https://openalex.org/W2116360854","https://openalex.org/W93335628","https://openalex.org/W2077540458","https://openalex.org/W1980165518","https://openalex.org/W2154550421"],"abstract_inverted_index":{"We":[0,132],"tested":[1],"the":[2,29,147],"hypothesis":[3],"that":[4,134,143],"chronic":[5],"maternal":[6,15,82,129,135],"GH":[7,38,52,78,118,136],"administration":[8],"would":[9],"increase":[10,14,68,158],"fetal":[11,17,32,84,95,104,122,151,160],"substrate":[12,152],"supply,":[13],"and":[16,24,83,88,106,111,121,154],"insulin-like":[18],"growth":[19,27,113],"factor":[20],"I":[21],"(IGF-I)":[22],"concentrations,":[23,87],"therefore":[25,155],"enhance":[26],"in":[28,69,146,159],"late":[30],"gestation":[31],"sheep.":[33],"Eleven":[34],"ewes":[35,49],"received":[36,50],"bovine":[37],"0.1":[39],"mg/kg":[40],"twice":[41],"daily":[42],"for":[43,57,72],"10":[44,47],"days,":[45],"whereas":[46],"control":[48],"saline.":[51],"treatment":[53,79,137],"increased":[54,94],"placental":[55,70,112,139],"capacity":[56,71],"simple":[58],"diffusion":[59,74],"(P":[60,75,98],"<":[61],"0.01),":[62],"with":[63],"a":[64,91],"trend":[65,92],"toward":[66,93],"an":[67,157],"facilitated":[73],"=":[76,99],"0.07).":[77,100],"also":[80],"lowered":[81],"blood":[85],"urea":[86],"there":[89],"was":[90,125],"protein":[96],"oxidation":[97],"Maternal":[101,120],"but":[102,142],"not":[103,115],"IGF-I":[105],"insulin":[107],"concentrations":[108],"increased.":[109],"Fetal":[110],"were":[114],"altered":[116],"by":[117,128],"treatment.":[119],"metabolic":[123],"status":[124],"significantly":[126],"affected":[127],"food":[130],"intake.":[131],"conclude":[133],"increases":[138],"transport":[140],"capacity,":[141],"anabolic":[144],"effects":[145],"mother":[148],"may":[149],"limit":[150],"supply":[153],"prevent":[156],"growth.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
