{"id":"https://openalex.org/W2008002124","doi":"https://doi.org/10.1016/j.jinorgbio.2009.10.005","title":"In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model","display_name":"In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model","publication_year":2009,"publication_date":"2009-10-15","ids":{"openalex":"https://openalex.org/W2008002124","doi":"https://doi.org/10.1016/j.jinorgbio.2009.10.005","mag":"2008002124","pmid":"https://pubmed.ncbi.nlm.nih.gov/19906432"},"language":"en","primary_location":{"id":"doi:10.1016/j.jinorgbio.2009.10.005","doi":"https://doi.org/10.1016/j.jinorgbio.2009.10.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jinorgbio.2009.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S155362585","display_name":"Journal of Inorganic Biochemistry","issn_l":"0162-0134","issn":["0162-0134","1873-3344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inorganic Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027691931","display_name":"Alberta Bergamo","orcid":"https://orcid.org/0000-0001-9021-8430","observed_orcids":["https://orcid.org/0000-0001-9021-8430"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Bergamo","raw_affiliation_strings":["Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy. a.bergamo@callerio.org","Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy. a.bergamo@callerio.org","institution_ids":[]},{"raw_affiliation_string":"Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061983659","display_name":"Alessia De Masi","orcid":"https://orcid.org/0000-0001-8453-6790","observed_orcids":["https://orcid.org/0000-0001-8453-6790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Masi","raw_affiliation_strings":["Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009736371","display_name":"Anna F. A. Peacock","orcid":"https://orcid.org/0000-0001-6809-9295","observed_orcids":["https://orcid.org/0000-0001-6809-9295"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.F.A. Peacock","raw_affiliation_strings":["School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041800171","display_name":"Abraha Habtemariam","orcid":"https://orcid.org/0000-0003-2128-800X","observed_orcids":["https://orcid.org/0000-0003-2128-800X"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Habtemariam","raw_affiliation_strings":["Department of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071855899","display_name":"Peter John Sadler","orcid":"https://orcid.org/0000-0001-9160-1941","observed_orcids":["https://orcid.org/0000-0001-9160-1941"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.J. Sadler","raw_affiliation_strings":["Department of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027632014","display_name":"Gianni Sava","orcid":"https://orcid.org/0000-0002-5138-6041","observed_orcids":["https://orcid.org/0000-0002-5138-6041"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Sava","raw_affiliation_strings":["Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy","Department of Life Sciences, University of Trieste, Via L. Giorgieri 7, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Callerio Foundation Onlus, Via A. Fleming 22-31, 34127 Trieste, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Life Sciences, University of Trieste, Via L. Giorgieri 7, Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027691931"],"corresponding_institution_ids":[],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":3.4772,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.92739017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"104","issue":"1","first_page":"79","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arene-ruthenium-complexes","display_name":"ruthenium(II) arene complexes","score":0.8209999799728394},{"id":"https://openalex.org/keywords/organometallic-anticancer-agents","display_name":"organometallic anticancer agents","score":0.8610000014305115},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8090000152587891},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hbl-100-cells","display_name":"HBL-100 cells","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7983019351959229},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7101927399635315},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5798535346984863},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5218295454978943},{"id":"https://openalex.org/C540285154","wikidata":"https://www.wikidata.org/wiki/Q751","display_name":"Osmium","level":4,"score":0.5177147388458252},{"id":"https://openalex.org/C555196967","wikidata":"https://www.wikidata.org/wiki/Q1086","display_name":"Ruthenium","level":3,"score":0.49357593059539795},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4866953194141388},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45802387595176697},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.43647801876068115},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3688434064388275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32571491599082947},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2819748520851135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19901591539382935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13366249203681946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08128643035888672},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009992","descriptor_name":"Osmium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009992","descriptor_name":"Osmium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012428","descriptor_name":"Ruthenium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012428","descriptor_name":"Ruthenium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jinorgbio.2009.10.005","doi":"https://doi.org/10.1016/j.jinorgbio.2009.10.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jinorgbio.2009.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S155362585","display_name":"Journal of Inorganic Biochemistry","issn_l":"0162-0134","issn":["0162-0134","1873-3344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inorganic Biochemistry","raw_type":"journal-article"},{"id":"pmid:19906432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19906432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of inorganic biochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:arts.units.it:11368/2292430","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/19906432?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/16ebc450-e696-4130-9a96-ba4fb686e223","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/16ebc450-e696-4130-9a96-ba4fb686e223","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bergamo, A, Masi, A, Peacock, A, Habtemariam, A, Sadler, PJ, Sava, G & Peacock, A 2010, 'In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model', Journal of Inorganic Biochemistry, vol. 104, no. 1, pp. 79-86. https://doi.org/10.1016/j.jinorgbio.2009.10.005","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327547","display_name":"Universit\u00e0 degli Studi di Trieste","ror":"https://ror.org/02n742c10"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1938617858","https://openalex.org/W1964314803","https://openalex.org/W1999374190","https://openalex.org/W1999481325","https://openalex.org/W2001976945","https://openalex.org/W2011855362","https://openalex.org/W2019661323","https://openalex.org/W2020462998","https://openalex.org/W2021527389","https://openalex.org/W2043610941","https://openalex.org/W2053236886","https://openalex.org/W2065402334","https://openalex.org/W2069305922","https://openalex.org/W2069305928","https://openalex.org/W2072961231","https://openalex.org/W2078261279","https://openalex.org/W2103459003","https://openalex.org/W2109689528","https://openalex.org/W2120064876","https://openalex.org/W2128635872","https://openalex.org/W2129213133","https://openalex.org/W2140895245","https://openalex.org/W2150473717","https://openalex.org/W2570750060"],"related_works":["https://openalex.org/W4321428316","https://openalex.org/W3202719162","https://openalex.org/W2050077837","https://openalex.org/W7096924884","https://openalex.org/W2268318987","https://openalex.org/W2137045520","https://openalex.org/W2281250036","https://openalex.org/W3041692918","https://openalex.org/W1970602323","https://openalex.org/W2019661323"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}