{"id":"https://openalex.org/W2007997953","doi":"https://doi.org/10.1136/bcr-2012-007786","title":"Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review","display_name":"Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review","publication_year":2013,"publication_date":"2013-01-03","ids":{"openalex":"https://openalex.org/W2007997953","doi":"https://doi.org/10.1136/bcr-2012-007786","mag":"2007997953","pmid":"https://pubmed.ncbi.nlm.nih.gov/23291819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3604362"},"language":"en","primary_location":{"id":"doi:10.1136/bcr-2012-007786","doi":"https://doi.org/10.1136/bcr-2012-007786","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bcr-2012-007786","pdf_url":"https://casereports.bmj.com/content/casereports/2013/bcr-2012-007786.full.pdf","source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://casereports.bmj.com/content/casereports/2013/bcr-2012-007786.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074920350","display_name":"Shahid Gilani","orcid":"https://orcid.org/0000-0002-1725-8484","observed_orcids":["https://orcid.org/0000-0002-1725-8484"]},"institutions":[{"id":"https://openalex.org/I2800115762","display_name":"University Hospitals of North Midlands NHS Trust","ror":"https://ror.org/03g47g866","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800115762"]},{"id":"https://openalex.org/I2800392559","display_name":"Royal Stoke University Hospital","ror":"https://ror.org/01dx1mr58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800115762","https://openalex.org/I2800392559"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Shahid Nazir Gilani","raw_affiliation_strings":["Department of Clinical Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK. shagi_g@hotmail.com","Department of Clinical Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK. shagi_g@hotmail.com","institution_ids":["https://openalex.org/I2800392559"]},{"raw_affiliation_string":"Department of Clinical Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","institution_ids":["https://openalex.org/I2800115762","https://openalex.org/I2800392559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106092296","display_name":"Rebecca Gridley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800392559","display_name":"Royal Stoke University Hospital","ror":"https://ror.org/01dx1mr58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800115762","https://openalex.org/I2800392559"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Gridley","raw_affiliation_strings":["Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","#N#2Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","institution_ids":["https://openalex.org/I2800392559"]},{"raw_affiliation_string":"#N#2Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","institution_ids":["https://openalex.org/I2800392559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110008913","display_name":"Gemma Searle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800392559","display_name":"Royal Stoke University Hospital","ror":"https://ror.org/01dx1mr58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800115762","https://openalex.org/I2800392559"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gemma Searle","raw_affiliation_strings":["Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","#N#2Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","institution_ids":["https://openalex.org/I2800392559"]},{"raw_affiliation_string":"#N#2Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","institution_ids":["https://openalex.org/I2800392559"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036095330","display_name":"Apurna Jegannathen","orcid":"https://orcid.org/0000-0002-4606-6924","observed_orcids":["https://orcid.org/0000-0002-4606-6924"]},"institutions":[{"id":"https://openalex.org/I2800392559","display_name":"Royal Stoke University Hospital","ror":"https://ror.org/01dx1mr58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800115762","https://openalex.org/I2800392559"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Apurna Jegannathen","raw_affiliation_strings":["Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","#N#2Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","institution_ids":["https://openalex.org/I2800392559"]},{"raw_affiliation_string":"#N#2Department of Oncology, University Hospital of North Staffordshire, Stoke On Trent, Staffordshire, UK","institution_ids":["https://openalex.org/I2800392559"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074920350"],"corresponding_institution_ids":["https://openalex.org/I2800115762","https://openalex.org/I2800392559"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2013","issue":null,"first_page":"bcr2012007786","last_page":"bcr2012007786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.1889999955892563,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-peritoneal-mesothelioma","display_name":"malignant peritoneal mesothelioma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5529999732971191},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.7149999737739563},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2777240266","wikidata":"https://www.wikidata.org/wiki/Q415220","display_name":"Pemetrexed","level":4,"score":0.9629470109939575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9561795592308044},{"id":"https://openalex.org/C2778995398","wikidata":"https://www.wikidata.org/wiki/Q7168876","display_name":"Peritoneal mesothelioma","level":3,"score":0.8949464559555054},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8285253047943115},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.8192336559295654},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5545741319656372},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5385274887084961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.513529360294342},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4428640305995941},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41296127438545227},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24485677480697632}],"mesh":[{"descriptor_ui":"D000068437","descriptor_name":"Pemetrexed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/bcr-2012-007786","doi":"https://doi.org/10.1136/bcr-2012-007786","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bcr-2012-007786","pdf_url":"https://casereports.bmj.com/content/casereports/2013/bcr-2012-007786.full.pdf","source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},{"id":"pmid:23291819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23291819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ case reports","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:3604362","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3604362/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/bcr-2012-007786","doi":"https://doi.org/10.1136/bcr-2012-007786","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bcr-2012-007786","pdf_url":"https://casereports.bmj.com/content/casereports/2013/bcr-2012-007786.full.pdf","source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007997953.pdf","grobid_xml":"https://content.openalex.org/works/W2007997953.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W125458566","https://openalex.org/W2005083372","https://openalex.org/W2012384646","https://openalex.org/W2012620143","https://openalex.org/W2066343477","https://openalex.org/W2101257527","https://openalex.org/W2148707299","https://openalex.org/W2166686383","https://openalex.org/W2218447279","https://openalex.org/W2410360630"],"related_works":["https://openalex.org/W2410360630","https://openalex.org/W2601244124","https://openalex.org/W2047119155","https://openalex.org/W2956925321","https://openalex.org/W4379648135","https://openalex.org/W2586853047","https://openalex.org/W2769028622","https://openalex.org/W2149504117","https://openalex.org/W4307688941","https://openalex.org/W4377043994"],"abstract_inverted_index":{"Peritoneal":[0],"mesothelioma":[1,23],"is":[2,7,24,61],"an":[3],"aggressive":[4],"malignancy":[5],"which":[6],"indeed":[8],"very":[9],"rare.":[10],"Due":[11],"to":[12,73],"rarity,":[13],"experience":[14],"among":[15],"many":[16],"physicians":[17],"surrounding":[18],"the":[19,57,63,79],"treatment":[20],"of":[21,40,49],"peritoneal":[22],"limited.":[25],"Recently,":[26],"we":[27],"have":[28],"received":[29],"a":[30,38],"patient":[31],"who":[32,76],"was":[33,53],"initially":[34],"treated":[35,55],"palliatively":[36],"with":[37,56],"combination":[39],"pemetrexd":[41,72],"and":[42,71],"cisplatin":[43,70],"showing":[44],"good":[45],"response.":[46],"On":[47],"progression":[48],"his":[50],"disease,":[51],"he":[52],"again":[54],"same":[58],"drugs.":[59],"This":[60],"not":[62],"strategy":[64],"commonly":[65],"used.":[66],"We":[67],"consider":[68],"rechallenging":[69],"such":[74],"patients":[75],"respond":[77],"for":[78],"first":[80],"time.":[81]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}