{"id":"https://openalex.org/W2007995014","doi":"https://doi.org/10.1071/srb10abs170","title":"170. THE ROLE OF MEGALIN IN PROSTATE DEVELOPMENT OF THE MOUSE","display_name":"170. THE ROLE OF MEGALIN IN PROSTATE DEVELOPMENT OF THE MOUSE","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2007995014","doi":"https://doi.org/10.1071/srb10abs170","mag":"2007995014"},"language":"en","primary_location":{"id":"doi:10.1071/srb10abs170","doi":"https://doi.org/10.1071/srb10abs170","is_oa":false,"landing_page_url":"https://doi.org/10.1071/srb10abs170","pdf_url":null,"source":{"id":"https://openalex.org/S199941106","display_name":"Reproduction Fertility and Development","issn_l":"1031-3613","issn":["1031-3613","1448-5990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320302","host_organization_name":"CSIRO Publishing","host_organization_lineage":["https://openalex.org/P4310320302"],"host_organization_lineage_names":["CSIRO Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction, Fertility and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000892176","display_name":"Melissa Gamat","orcid":"https://orcid.org/0000-0003-2943-8156","observed_orcids":["https://orcid.org/0000-0003-2943-8156"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. Gamat","raw_affiliation_strings":["Department of Zoology, The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027940556","display_name":"Geoff Shaw","orcid":"https://orcid.org/0000-0002-7421-7136","observed_orcids":["https://orcid.org/0000-0002-7421-7136"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G. Shaw","raw_affiliation_strings":["Department of Zoology, The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059662490","display_name":"Marilyn B. Renfree","orcid":"https://orcid.org/0000-0002-4589-0436","observed_orcids":["https://orcid.org/0000-0002-4589-0436"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. B. Renfree","raw_affiliation_strings":["Department of Zoology, The University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, The University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165779595"],"apc_list":null,"apc_paid":null,"fwci":0.2658,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66050442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"9","first_page":"88","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.05739999935030937,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/megalin","display_name":"megalin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-development","display_name":"prostate development","score":0.921999990940094},{"id":"https://openalex.org/keywords/urogenital-sinus","display_name":"urogenital sinus","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.8309999704360962},{"id":"https://openalex.org/keywords/receptor-associated-protein","display_name":"receptor-associated protein","score":0.968999981880188},{"id":"https://openalex.org/keywords/androgen-signaling","display_name":"androgen signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5879578590393066},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5660150051116943},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5541530847549438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5459827184677124},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4963732361793518},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.46956324577331543},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.4593750238418579},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4415688216686249},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42412009835243225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38377752900123596},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.36954036355018616},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1645294725894928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14425864815711975},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06435573101043701}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1071/srb10abs170","doi":"https://doi.org/10.1071/srb10abs170","is_oa":false,"landing_page_url":"https://doi.org/10.1071/srb10abs170","pdf_url":null,"source":{"id":"https://openalex.org/S199941106","display_name":"Reproduction Fertility and Development","issn_l":"1031-3613","issn":["1031-3613","1448-5990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320302","host_organization_name":"CSIRO Publishing","host_organization_lineage":["https://openalex.org/P4310320302"],"host_organization_lineage_names":["CSIRO Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction, Fertility and Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019409860","https://openalex.org/W4245134448","https://openalex.org/W2092723228","https://openalex.org/W2998735788","https://openalex.org/W2061424771","https://openalex.org/W2152259313","https://openalex.org/W1967656765","https://openalex.org/W2015855151","https://openalex.org/W2066000490","https://openalex.org/W4247397298"],"abstract_inverted_index":{"Prostatic":[0],"development":[1,167],"is":[2,16,84,90,96,116,275,292],"dependent":[3,63],"on":[4,64],"androgens;":[5],"but":[6],"the":[7,40,52,93,105,132,138,150,156,166,169,180,187,203,214,219,233,252,283,295],"precise":[8],"mechanism":[9],"by":[10],"which":[11,61,83],"androgens":[12,148,231],"mediate":[13],"their":[14],"effect":[15],"still":[17],"unclear.":[18],"Megalin,":[19,172,206],"a":[20,117,160],"cell":[21,139,151],"membrane":[22],"transporter,":[23],"may":[24,145],"shuttle":[25,146],"sex":[26,65,78,94,310],"steroids":[27,79],"into":[28,137],"cells":[29],"to":[30,55,81,104,108,128,135,192,199,262,265],"regulate":[31,109],"androgen-responsive":[32],"genes":[33],"responsible":[34],"for":[35,163],"prostatic":[36,196,224,247,258,279],"bud":[37,248,259,280],"induction":[38],"in":[39,57,131,165,179,202,213,223,232,251,278,294,306],"urogenital":[41,215],"sinus":[42],"(UGS).":[43],"In":[44,73],"megalin":[45,125,144,164,222,255,274,287],"knockout":[46,256],"mice,":[47,257],"testicular":[48],"descent":[49],"fails":[50,54],"and":[51,92,158,174,183,201,208,235],"vagina":[53],"open":[56],"females,":[58],"both":[59],"of":[60,168,186,221,237,254,267,286,304,309],"are":[62],"steroid":[66,88,95],"signalling":[67],"(Hammes":[68],"et":[69,300],"al.":[70,301],"2005)":[71],".":[72],"this":[74],"megalin-mediated":[75],"pathway,":[76],"SHBG-bound":[77,147],"bind":[80,103],"megalin,":[82],"internalised.":[85],"The":[86],"SHBG-sex":[87],"complex":[89],"released,":[91],"released":[97],"from":[98,126,189],"SHBG":[99,173,207],"where":[100],"it":[101],"can":[102],"androgen":[106,110],"receptor":[107],"responsive":[111],"genes.":[112],"Receptor-Associated":[113],"Protein":[114],"(RAP)":[115],"molecular":[118],"chaperone":[119],"protein":[120,210],"that":[121,143,273,289],"protects":[122],"newly":[123],"synthesised":[124],"binding":[127],"potential":[129],"ligands":[130],"cytoplasm":[133],"prior":[134],"insertion":[136],"membrane.":[140,152],"We":[141],"hypothesised":[142],"across":[149],"This":[153],"study":[154],"characterised":[155],"expression":[157,285],"evaluated":[159],"possible":[161],"role":[162,220,291],"mouse":[170,188],"prostate.":[171,205,296],"RAP":[175,209,243],"transcripts":[176],"were":[177,211,228],"detected":[178],"developing":[181],"male":[182],"female":[184],"UGS":[185,226,240,253],"day":[190,193],"E14.5":[191],"E18.5":[194],"(when":[195],"buds":[197],"start":[198],"form)":[200],"adult":[204],"localised":[212],"epithelium.":[216],"To":[217],"assess":[218],"development,":[225],"tissues":[227,241],"incubated":[229],"with":[230,242],"presence":[234],"absence":[236],"RAP.":[238],"Incubating":[239],"did":[244],"NOT":[245],"inhibit":[246],"initiation.":[249,281],"Furthermore,":[250],"formation":[260],"appeared":[261],"be":[263],"identical":[264],"those":[266],"wild-type":[268],"littermates.":[269],"These":[270],"results":[271],"demonstrate":[272],"not":[276],"involved":[277],"However,":[282],"ubiquitous":[284],"suggests":[288],"its":[290],"redundant":[293],"(1)":[297],"Hammes":[298],"A":[299],"(2005)":[302],"Role":[303],"endocytosis":[305],"cellular":[307],"uptake":[308],"steroids.":[311],"Cell":[312],"122(5),":[313],"751\u201362.":[314]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
