{"id":"https://openalex.org/W2007992544","doi":"https://doi.org/10.1021/bi00681a011","title":"Insulin degradation. XIV. Interaction of insulin analogs, glucagon, growth hormone, vasopressin, oxytocin, and scrambled forms of ribonuclease and lysozyme with glutathione-insulin transhydrogenase (thiol:protein-disulfide oxidoreductase). Dependence upon conformation","display_name":"Insulin degradation. XIV. Interaction of insulin analogs, glucagon, growth hormone, vasopressin, oxytocin, and scrambled forms of ribonuclease and lysozyme with glutathione-insulin transhydrogenase (thiol:protein-disulfide oxidoreductase). Dependence upon conformation","publication_year":1975,"publication_date":"1975-05-20","ids":{"openalex":"https://openalex.org/W2007992544","doi":"https://doi.org/10.1021/bi00681a011","mag":"2007992544","pmid":"https://pubmed.ncbi.nlm.nih.gov/1170877"},"language":"en","primary_location":{"id":"doi:10.1021/bi00681a011","doi":"https://doi.org/10.1021/bi00681a011","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00681a011","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111711925","display_name":"Partab T. Varandani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Partab T. Varandani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083110762","display_name":"Mary Ann Nafz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary A. Nafz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110697480","display_name":"Michael L. Chandler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael L. Chandler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.5972,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.81223011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"10","first_page":"2115","last_page":"2120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.49630001187324524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.49630001187324524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.26420000195503235,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-degradation","display_name":"insulin degradation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glutathione-insulin-transhydrogenase","display_name":"glutathione-insulin transhydrogenase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/insulin-analogs","display_name":"insulin analogues","score":0.9369999766349792},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.7049999833106995},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.6179999709129333},{"id":"https://openalex.org/keywords/ribonuclease","display_name":"ribonuclease","score":0.875},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.8980000019073486},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.996999979019165},{"id":"https://openalex.org/keywords/proinsulin","display_name":"proinsulin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7606152296066284},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.6457881331443787},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6153689026832581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6124477386474609},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5742077827453613},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.5361151099205017},{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.5343223214149475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5178144574165344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48904380202293396},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.48165762424468994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4664815068244934},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.46326497197151184},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.4358171224594116},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.4348592162132263},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27105116844177246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2296839952468872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011490","descriptor_name":"Protein Disulfide Reductase (Glutathione)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00681a011","doi":"https://doi.org/10.1021/bi00681a011","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00681a011","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:1170877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1170877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W18808801","https://openalex.org/W118660810","https://openalex.org/W128878926","https://openalex.org/W195700238","https://openalex.org/W1517356485","https://openalex.org/W1545566831","https://openalex.org/W1565595177","https://openalex.org/W1571793851","https://openalex.org/W1590877325","https://openalex.org/W1639442759","https://openalex.org/W1965299772","https://openalex.org/W1978769726","https://openalex.org/W1980293817","https://openalex.org/W2000229590","https://openalex.org/W2006370393","https://openalex.org/W2009874209","https://openalex.org/W2037104706","https://openalex.org/W2037463469","https://openalex.org/W2038583764","https://openalex.org/W2040629399","https://openalex.org/W2064429122","https://openalex.org/W2068175480","https://openalex.org/W2068523606","https://openalex.org/W2071140723","https://openalex.org/W2078876644","https://openalex.org/W2083550236","https://openalex.org/W2083710146","https://openalex.org/W2086906852","https://openalex.org/W2087645206","https://openalex.org/W2089042653","https://openalex.org/W2159967182","https://openalex.org/W4298359578"],"related_works":["https://openalex.org/W2000211263","https://openalex.org/W2431362212","https://openalex.org/W2045776791","https://openalex.org/W1978769726","https://openalex.org/W2076136144","https://openalex.org/W2068735550","https://openalex.org/W2047729026","https://openalex.org/W2056697335","https://openalex.org/W2110754220","https://openalex.org/W2416190450"],"abstract_inverted_index":{"Interactions":[0],"of":[1,18,70,100,108,164,176,191,195,199,203,209],"several":[2],"proteins":[3],"with":[4,59,94,135,142,146],"glutathione-insulin":[5],"transhydrogenase":[6],"(GIT)":[7],"have":[8],"been":[9],"investigated":[10],"by":[11,22,26,157],"determining":[12,119],"their":[13,83],"ability":[14],"to":[15,172],"inhibit":[16],"degradation":[17],"125I-labeled":[19],"insulin":[20,28,48,57,71],"catalyzed":[21],"GIT.":[23],"The":[24,56,144,155,178],"inhibition":[25,93,134,141,145,156],"every":[27],"analog":[29],"(des-Asn-des-Ala-pork":[30],"insulin,":[31,33,35,37],"desoctapeptide-pork":[32],"des-Ala-pork":[34],"pork":[36,204],"proinsulin,":[38,205],"and":[39,76,88,137,139,159,188,198,206],"guinea":[40],"pig":[41],"insulin)":[42,165],"was":[43],"competitive":[44,46,92,133,152],"vs.":[45,47],"indicating":[49],"that":[50,99,105],"they":[51],"function":[52],"as":[53,68,168],"alternate":[54],"substrates.":[55],"analogs":[58],"the":[60,65,106,109,115,120,126,174,186],"least":[61],"hormonal":[62],"activity":[63,175],"showed":[64,78,91,132,180],"highest":[66],"potency":[67,96],"inhigitors":[69],"degradation.":[72],"Whereas":[73],"native":[74,187],"ribonuclease":[75],"lysozyme":[77],"little":[79,182],"or":[80,111,153,183],"no":[81,184],"inhibition,":[82],"scrambled":[84,189],"forms":[85],"(i.e.":[86],"reduced":[87],"randomly":[89],"reoxidized)":[90],"a":[95,169],"greater":[97],"than":[98],"insulin.":[101,210],"These":[102],"results":[103],"suggest":[104],"conformation":[107],"substrate":[110],"inhibitor":[112,194],"is":[113],"probably":[114],"major":[116],"factor":[117],"in":[118],"specificity":[121],"for":[122],"(or":[123],"binding":[124],"to)":[125],"enzyme.":[127,177],"Studies":[128],"withother":[129],"peptide":[130],"hormones":[131],"vasopressin":[136],"oxytocin":[138],"noncompetitive":[140],"glycagon.":[143],"growth":[147,160],"hormone":[148,161],"could":[149,166],"be":[150],"either":[151],"noncompetitive.":[154],"glucagon":[158],"(physiologic":[162],"antagonists":[163],"serve":[167],"control":[170],"mechanism":[171],"modulate":[173],"following":[179],"very":[181],"inhibition;":[185],"form":[190],"pepsinogen,":[192],"trypsin":[193],"beef":[196],"pancreas":[197],"lima":[200],"bean,":[201],"C-peptide":[202],"heptapeptide":[207],"(B23-B29)":[208]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}