{"id":"https://openalex.org/W2007991956","doi":"https://doi.org/10.1017/s0022172400042303","title":"The extracellular antigens of Micropolyspora faeni: their significance in farmer's lung disease","display_name":"The extracellular antigens of Micropolyspora faeni: their significance in farmer's lung disease","publication_year":1970,"publication_date":"1970-09-01","ids":{"openalex":"https://openalex.org/W2007991956","doi":"https://doi.org/10.1017/s0022172400042303","mag":"2007991956","pmid":"https://pubmed.ncbi.nlm.nih.gov/4989855","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2130828"},"language":"en","primary_location":{"id":"doi:10.1017/s0022172400042303","doi":"https://doi.org/10.1017/s0022172400042303","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0022172400042303","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0F97879E46440837E245FF8F6221452D/S0022172400042303a.pdf/div-class-title-the-extracellular-antigens-of-span-class-italic-micropolyspora-faeni-span-their-significance-in-farmer-s-lung-disease-div.pdf","source":{"id":"https://openalex.org/S4210200397","display_name":"Journal of Hygiene","issn_l":"0022-1724","issn":["0022-1724","2396-8184"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0F97879E46440837E245FF8F6221452D/S0022172400042303a.pdf/div-class-title-the-extracellular-antigens-of-span-class-italic-micropolyspora-faeni-span-their-significance-in-farmer-s-lung-disease-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032906337","display_name":"S.M. Fletcher","orcid":"https://orcid.org/0000-0001-7169-620X","observed_orcids":["https://orcid.org/0000-0001-7169-620X"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. M. Fletcher","raw_affiliation_strings":["Department of Bacteriology and Immunology, and Mycological Reference Laboratory of the Public Health Laboratory Service, both at the London School of Hygiene and Tropical Medicine, London. W.C.1","both at the London School of Hygiene and Tropical Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology and Immunology, and Mycological Reference Laboratory of the Public Health Laboratory Service, both at the London School of Hygiene and Tropical Medicine, London. W.C.1","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"both at the London School of Hygiene and Tropical Medicine","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058574684","display_name":"C. J. M. Rondle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. J. M. Rondle","raw_affiliation_strings":["Department of Bacteriology and Immunology, and Mycological Reference Laboratory of the Public Health Laboratory Service, both at the London School of Hygiene and Tropical Medicine, London. W.C.1","both at the London School of Hygiene and Tropical Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology and Immunology, and Mycological Reference Laboratory of the Public Health Laboratory Service, both at the London School of Hygiene and Tropical Medicine, London. W.C.1","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"both at the London School of Hygiene and Tropical Medicine","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025256168","display_name":"Ian G. Murray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. G. Murray","raw_affiliation_strings":["Department of Bacteriology and Immunology, and Mycological Reference Laboratory of the Public Health Laboratory Service, both at the London School of Hygiene and Tropical Medicine, London. W.C.1","both at the London School of Hygiene and Tropical Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology and Immunology, and Mycological Reference Laboratory of the Public Health Laboratory Service, both at the London School of Hygiene and Tropical Medicine, London. W.C.1","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"both at the London School of Hygiene and Tropical Medicine","institution_ids":["https://openalex.org/I4210089966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210089966"],"apc_list":null,"apc_paid":null,"fwci":3.4282,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.89305302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"68","issue":"3","first_page":"401","last_page":"409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.16580000519752502,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micropolyspora-faeni","display_name":"Micropolyspora faeni","score":0.9769999980926514},{"id":"https://openalex.org/keywords/farmer-s-lung","display_name":"farmer's lung","score":0.9160000085830688},{"id":"https://openalex.org/keywords/extracellular-antigens","display_name":"extracellular antigens","score":0.8669999837875366},{"id":"https://openalex.org/keywords/precipitating-antibodies","display_name":"precipitating antibodies","score":0.781000018119812},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.6380000114440918},{"id":"https://openalex.org/keywords/fungal-exposure","display_name":"fungal exposure","score":0.34299999475479126},{"id":"https://openalex.org/keywords/respiratory-diseases","display_name":"respiratory diseases","score":0.6600000262260437},{"id":"https://openalex.org/keywords/immunodiffusion","display_name":"immunodiffusion","score":0.6970000267028809},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C133229898","wikidata":"https://www.wikidata.org/wiki/Q7239484","display_name":"Precipitin","level":3,"score":0.9359169006347656},{"id":"https://openalex.org/C2775883245","wikidata":"https://www.wikidata.org/wiki/Q1396859","display_name":"Farmer's lung","level":3,"score":0.9220458269119263},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.8016014099121094},{"id":"https://openalex.org/C196955773","wikidata":"https://www.wikidata.org/wiki/Q256632","display_name":"Immunodiffusion","level":3,"score":0.6581799983978271},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6489816308021545},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.6266727447509766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5220139622688293},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.48673108220100403},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47109919786453247},{"id":"https://openalex.org/C80020023","wikidata":"https://www.wikidata.org/wiki/Q12730368","display_name":"Ouchterlony double immunodiffusion","level":4,"score":0.4536955654621124},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.437260240316391},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4133656919002533},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.31169503927230835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18299943208694458},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000190","descriptor_name":"Actinomyces","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005203","descriptor_name":"Farmer's Lung","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005203","descriptor_name":"Farmer's Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011234","descriptor_name":"Precipitins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1017/s0022172400042303","doi":"https://doi.org/10.1017/s0022172400042303","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0022172400042303","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0F97879E46440837E245FF8F6221452D/S0022172400042303a.pdf/div-class-title-the-extracellular-antigens-of-span-class-italic-micropolyspora-faeni-span-their-significance-in-farmer-s-lung-disease-div.pdf","source":{"id":"https://openalex.org/S4210200397","display_name":"Journal of Hygiene","issn_l":"0022-1724","issn":["0022-1724","2396-8184"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hygiene","raw_type":"journal-article"},{"id":"pmid:4989855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4989855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of hygiene","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2130828","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2130828/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hyg (Lond)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1017/s0022172400042303","doi":"https://doi.org/10.1017/s0022172400042303","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0022172400042303","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0F97879E46440837E245FF8F6221452D/S0022172400042303a.pdf/div-class-title-the-extracellular-antigens-of-span-class-italic-micropolyspora-faeni-span-their-significance-in-farmer-s-lung-disease-div.pdf","source":{"id":"https://openalex.org/S4210200397","display_name":"Journal of Hygiene","issn_l":"0022-1724","issn":["0022-1724","2396-8184"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hygiene","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007991956.pdf","grobid_xml":"https://content.openalex.org/works/W2007991956.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1520745268","https://openalex.org/W1524523775","https://openalex.org/W1559616193","https://openalex.org/W1653620410","https://openalex.org/W1758312163","https://openalex.org/W1937316137","https://openalex.org/W1957851884","https://openalex.org/W1965537764","https://openalex.org/W1972304044","https://openalex.org/W1981606699","https://openalex.org/W1991704329","https://openalex.org/W2018257927","https://openalex.org/W2019244584","https://openalex.org/W2022619320","https://openalex.org/W2026099642","https://openalex.org/W2035235611","https://openalex.org/W2038834473","https://openalex.org/W2045559730","https://openalex.org/W2073955472","https://openalex.org/W2081089768","https://openalex.org/W2083004179","https://openalex.org/W2083279112","https://openalex.org/W2085181261","https://openalex.org/W2147592341","https://openalex.org/W2165900115","https://openalex.org/W2223415603","https://openalex.org/W2285458529","https://openalex.org/W2333702827","https://openalex.org/W2411561216","https://openalex.org/W2472701602","https://openalex.org/W2916378941","https://openalex.org/W4255633642","https://openalex.org/W6799437608"],"related_works":["https://openalex.org/W1915745155","https://openalex.org/W2280554679","https://openalex.org/W2157670939","https://openalex.org/W2127474357","https://openalex.org/W2397309067","https://openalex.org/W2170615942","https://openalex.org/W2085757232","https://openalex.org/W1999050634","https://openalex.org/W2413761107","https://openalex.org/W2158710241"],"abstract_inverted_index":{"A":[0,21],"serological":[1],"analysis":[2],"of":[3,7,15,25,28,53,60,81,89,100,102,114,123,130,133,137,160],"the":[4,26,31,68,103,112,154],"extracellular":[5],"antigens":[6,32,93,141],"Micropolyspora":[8],"faeni":[9],"by":[10,98],"immunodiffusion":[11],"with":[12,37,105,127],"a":[13,128],"combination":[14],"sera":[16,34,77],"revealed":[17],"29":[18],"individual":[19,92,140],"antigens.":[20],"survey":[22],"was":[23,49,94,145,156],"made":[24],"incidence":[27,155],"precipitins":[29,90,106,138],"to":[30,67,91,107,139,147],"in":[33,51,58,76,142,149],"from":[35,78,84,118],"patients":[36,104,152],"clinical":[38,150],"farmer's":[39,54],"lung":[40,55],"disease":[41],"(FLD)":[42],"and":[43,57],"other":[44,61,124],"respiratory":[45,125],"diseases.":[46],"Precipitating":[47],"antibody":[48],"found":[50],"75%":[52],"cases":[56,62],"20%":[59],"who":[63],"had":[64],"been":[65],"exposed":[66],"same":[69],"environment.":[70],"More":[71],"precipitin":[72],"reactions":[73],"were":[74,116],"seen":[75],"severe":[79],"forms":[80],"FLD":[82,151],"than":[83],"milder":[85],"forms.":[86],"The":[87,135],"distribution":[88,136],"not":[95],"significantly":[96],"affected":[97],"severity":[99],"disease.Most":[101],"M.":[108],"faeni,":[109],"but":[110,153],"without":[111],"symptoms":[113,122],"FLD,":[115],"suffering":[117],"mild":[119],"or":[120],"moderate":[121],"diseases":[126],"history":[129],"chronic":[131],"onset":[132],"symptoms.":[134],"this":[143],"group":[144],"similar":[146],"that":[148],"considerably":[157],"lower.The":[158],"significance":[159],"these":[161],"results":[162],"is":[163],"discussed.":[164]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
