{"id":"https://openalex.org/W2007984253","doi":"https://doi.org/10.1021/jo060058h","title":"Synthesis of an Inhibitor-Tethered Resin for Detection of Active Matrix Metalloproteinases Involved in Disease","display_name":"Synthesis of an Inhibitor-Tethered Resin for Detection of Active Matrix Metalloproteinases Involved in Disease","publication_year":2006,"publication_date":"2006-07-11","ids":{"openalex":"https://openalex.org/W2007984253","doi":"https://doi.org/10.1021/jo060058h","mag":"2007984253","pmid":"https://pubmed.ncbi.nlm.nih.gov/16872162"},"language":"en","primary_location":{"id":"doi:10.1021/jo060058h","doi":"https://doi.org/10.1021/jo060058h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo060058h","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069198023","display_name":"Du\u0161an Hesek","orcid":"https://orcid.org/0000-0001-6288-8824","observed_orcids":["https://orcid.org/0000-0001-6288-8824"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dusan Hesek","raw_affiliation_strings":["Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109883780","display_name":"M\u00e1rta T\u00f3th","orcid":"https://orcid.org/0000-0002-0442-1553","observed_orcids":["https://orcid.org/0000-0002-0442-1553"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Toth","raw_affiliation_strings":["Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006798993","display_name":"Viktor Krch\u0148\u00e1k","orcid":"https://orcid.org/0000-0001-5688-4069","observed_orcids":["https://orcid.org/0000-0001-5688-4069"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viktor Krch\u0148\u00e1k","raw_affiliation_strings":["Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110246788","display_name":"Rafael Fridman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael Fridman","raw_affiliation_strings":["Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013812375","display_name":"Shahriar Mobashery","orcid":"https://orcid.org/0000-0002-7695-7883","observed_orcids":["https://orcid.org/0000-0002-7695-7883"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahriar Mobashery","raw_affiliation_strings":["Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201","institution_ids":["https://openalex.org/I107639228","https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2618,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.59780837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"71","issue":"16","first_page":"5848","last_page":"5854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-inhibitors","display_name":"matrix metalloproteinase inhibitors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chromatographic-resins","display_name":"chromatographic resins","score":0.6940000057220459},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.6759999990463257},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/inhibitor-synthesis","display_name":"inhibitor synthesis","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8947064876556396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8148739337921143},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.5785723328590393},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4824253022670746},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.46611717343330383},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45552879571914673},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.4525425434112549},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.42321521043777466},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.41944289207458496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4031904637813568},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3243827223777771},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.129831463098526},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0868828296661377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06598213315010071}],"mesh":[{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jo060058h","doi":"https://doi.org/10.1021/jo060058h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo060058h","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:16872162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16872162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W74544524","https://openalex.org/W1973048790","https://openalex.org/W1976396639","https://openalex.org/W1980704103","https://openalex.org/W1983247913","https://openalex.org/W1984483611","https://openalex.org/W1987669529","https://openalex.org/W2003500892","https://openalex.org/W2024834587","https://openalex.org/W2035410475","https://openalex.org/W2052457042","https://openalex.org/W2057481167","https://openalex.org/W2057896496","https://openalex.org/W2083709143","https://openalex.org/W2102884576","https://openalex.org/W2125932935"],"related_works":["https://openalex.org/W2058196508","https://openalex.org/W2068722282","https://openalex.org/W1989546830","https://openalex.org/W2109458294","https://openalex.org/W130008276","https://openalex.org/W2083001139","https://openalex.org/W4313017660","https://openalex.org/W7098058386","https://openalex.org/W2110827209","https://openalex.org/W2022172589"],"abstract_inverted_index":{"Matrix":[0],"metalloproteinases":[1],"(MMPs),":[2],"of":[3,16,56,93,122],"which":[4],"26":[5],"members":[6],"are":[7,11,55,107],"known":[8],"in":[9,13,48,87,111],"humans,":[10],"implicated":[12],"a":[14,71,119],"number":[15],"diseases.":[17],"Their":[18],"activity":[19,30,44],"is":[20,31],"strictly":[21],"controlled,":[22],"but":[23],"when":[24],"the":[25,29,94,99,126,132],"biological":[26],"control":[27],"over":[28],"lost,":[32],"disease":[33,134],"processes":[34],"set":[35],"in.":[36],"In":[37],"an":[38],"attempt":[39],"to":[40,59,98,114],"delineate":[41],"what":[42,49],"MMP":[43,128],"has":[45],"gone":[46],"awry":[47],"diseases,":[50],"including":[51],"metastatic":[52],"cancers":[53],"that":[54],"special":[57],"interest":[58],"our":[60],"laboratories,":[61],"we":[62],"conceived":[63],"and":[64,84],"synthesized":[65,86],"two":[66],"chromatographic":[67],"resins":[68,106],"incorporated":[69],"with":[70],"multifunctional":[72],"broad-spectrum":[73,78],"inhibitor":[74,79],"for":[75,109,131,135],"MMPs.":[76],"The":[77],"contains":[80],"three":[81],"sterogentic":[82],"centers":[83],"was":[85],"13":[88],"steps.":[89],"Two":[90],"structural":[91],"variants":[92],"inhibitors":[95],"were":[96],"linked":[97],"polymer":[100],"support":[101],"via":[102],"disulfide":[103],"moieties.":[104],"These":[105],"intended":[108],"use":[110],"cellular":[112,124],"systems":[113],"selectively":[115],"fish":[116],"out":[117],"from":[118],"complex":[120],"mixture":[121],"all":[123],"proteins":[125],"active":[127],"forms":[129],"important":[130],"specific":[133],"identification.":[136]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}