{"id":"https://openalex.org/W2007979003","doi":"https://doi.org/10.1371/journal.pone.0061432","title":"FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/\u03b2-Klotho Bispecific Protein","display_name":"FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/\u03b2-Klotho Bispecific Protein","publication_year":2013,"publication_date":"2013-04-22","ids":{"openalex":"https://openalex.org/W2007979003","doi":"https://doi.org/10.1371/journal.pone.0061432","mag":"2007979003","pmid":"https://pubmed.ncbi.nlm.nih.gov/23630589","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3632592"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0061432","doi":"https://doi.org/10.1371/journal.pone.0061432","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061432","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061432&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061432&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014833790","display_name":"Richard J. Smith","orcid":"https://orcid.org/0000-0003-1201-6731","observed_orcids":["https://orcid.org/0000-0003-1201-6731"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Smith","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065028247","display_name":"Amy N. Duguay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Duguay","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035774297","display_name":"Alice Bakker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Bakker","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432789","display_name":"Peng Li","orcid":"https://orcid.org/0000-0003-4530-2400","observed_orcids":["https://orcid.org/0000-0003-4530-2400"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008884508","display_name":"Jennifer Weiszmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Weiszmann","raw_affiliation_strings":["Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079700773","display_name":"Melissa R. Thomas","orcid":"https://orcid.org/0000-0001-6719-9307","observed_orcids":["https://orcid.org/0000-0001-6719-9307"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa R. Thomas","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054938212","display_name":"Benjamin M. Alba","orcid":"https://orcid.org/0000-0003-4181-6797","observed_orcids":["https://orcid.org/0000-0003-4181-6797"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin M. Alba","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049385707","display_name":"Xinle Wu","orcid":"https://orcid.org/0000-0002-0533-2499","observed_orcids":["https://orcid.org/0000-0002-0533-2499"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinle Wu","raw_affiliation_strings":["Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070199717","display_name":"Jamila Gupte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamila Gupte","raw_affiliation_strings":["Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421612","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-7134-5685","observed_orcids":["https://orcid.org/0000-0002-7134-5685"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Yang","raw_affiliation_strings":["Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088327133","display_name":"Jennitte L. Stevens","orcid":"https://orcid.org/0000-0002-4081-4696","observed_orcids":["https://orcid.org/0000-0002-4081-4696"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennitte Stevens","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031725051","display_name":"Agnes E. Hamburger","orcid":"https://orcid.org/0000-0002-2679-3673","observed_orcids":["https://orcid.org/0000-0002-2679-3673"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agnes Hamburger","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082121870","display_name":"Stephen H. Smith","orcid":"https://orcid.org/0000-0002-6759-3993","observed_orcids":["https://orcid.org/0000-0002-6759-3993"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Smith","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., Thousand Oaks, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039390366","display_name":"Jiyun Chen","orcid":"https://orcid.org/0000-0003-0434-5666","observed_orcids":["https://orcid.org/0000-0003-0434-5666"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyun Chen","raw_affiliation_strings":["Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States of America","Pharmacokinetics & Drug Metabolism, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Pharmacokinetics & Drug Metabolism, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084427684","display_name":"Ren\u00e9e Komorowski","orcid":"https://orcid.org/0000-0002-6233-4036","observed_orcids":["https://orcid.org/0000-0002-6233-4036"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee Komorowski","raw_affiliation_strings":["Metabolic Disorders, Amgen Inc., Thousand Oaks, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders, Amgen Inc., Thousand Oaks, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113521630","display_name":"Kevin W. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin W. Moore","raw_affiliation_strings":["Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Discovery, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012830823","display_name":"Murielle M. V\u00e9niant","orcid":"https://orcid.org/0000-0002-1881-8252","observed_orcids":["https://orcid.org/0000-0002-1881-8252"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murielle M. V\u00e9niant","raw_affiliation_strings":["Metabolic Disorders, Amgen Inc., Thousand Oaks, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders, Amgen Inc., Thousand Oaks, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100421612","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-7134-5685","observed_orcids":["https://orcid.org/0000-0002-7134-5685"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yang Li","raw_affiliation_strings":["Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Disorders, Amgen Inc., South San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1320553840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100421612"],"corresponding_institution_ids":["https://openalex.org/I1320553840"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.8593,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92257194,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"8","issue":"4","first_page":"e61432","last_page":"e61432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf21","display_name":"FGF21","score":0.996999979019165},{"id":"https://openalex.org/keywords/fgfr1c","display_name":"FGFR1c","score":0.9150000214576721},{"id":"https://openalex.org/keywords/beta-klotho","display_name":"\u03b2-Klotho","score":0.9610000252723694},{"id":"https://openalex.org/keywords/diabetes-treatment","display_name":"diabetes treatment","score":0.5789999961853027},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8700000047683716},{"id":"https://openalex.org/keywords/metabolic-effects","display_name":"metabolic effects","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.8962996006011963},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5533633828163147},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5445102453231812},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5404354929924011},{"id":"https://openalex.org/C9832595","wikidata":"https://www.wikidata.org/wiki/Q414050","display_name":"Klotho","level":3,"score":0.48619312047958374},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4638051986694336},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4543948471546173},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4460429549217224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41407400369644165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34959346055984497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3421030044555664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.326307088136673},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.2891719341278076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11501574516296387},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.08404380083084106},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090265","descriptor_name":"Klotho Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051496","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0061432","doi":"https://doi.org/10.1371/journal.pone.0061432","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061432","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061432&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2633611","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3632592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3632592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3632592","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23630589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23630589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.5782","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.5782","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/41/3c/pone.0061432.PMC3632592.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:94370a4c5af3418bafae3672e5e4eb24","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/94370a4c5af3418bafae3672e5e4eb24","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 4, p e61432 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/687888","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_FGF21_Can_Be_Mimicked_In_Vitro_and_In_Vivo_by_a_Novel_Anti_FGFR1c_946_Klotho_Bispecific_Protein_/687888","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0061432","doi":"https://doi.org/10.1371/journal.pone.0061432","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061432","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061432&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007979003.pdf","grobid_xml":"https://content.openalex.org/works/W2007979003.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1486302655","https://openalex.org/W1968091833","https://openalex.org/W1977516373","https://openalex.org/W1982622656","https://openalex.org/W2000665430","https://openalex.org/W2002915072","https://openalex.org/W2002989289","https://openalex.org/W2003072687","https://openalex.org/W2008635725","https://openalex.org/W2011712684","https://openalex.org/W2013107026","https://openalex.org/W2020597644","https://openalex.org/W2020958481","https://openalex.org/W2033600464","https://openalex.org/W2034198983","https://openalex.org/W2042055907","https://openalex.org/W2044779183","https://openalex.org/W2044931811","https://openalex.org/W2048285167","https://openalex.org/W2048411348","https://openalex.org/W2060420218","https://openalex.org/W2061333499","https://openalex.org/W2061512091","https://openalex.org/W2064125892","https://openalex.org/W2074337024","https://openalex.org/W2076037986","https://openalex.org/W2086624706","https://openalex.org/W2110708451","https://openalex.org/W2111653877","https://openalex.org/W2114650931","https://openalex.org/W2119331212","https://openalex.org/W2119351413","https://openalex.org/W2123472956","https://openalex.org/W2125929584","https://openalex.org/W2130700195","https://openalex.org/W2144461742","https://openalex.org/W2145044799","https://openalex.org/W2149594557","https://openalex.org/W2168118376","https://openalex.org/W2174253635","https://openalex.org/W2265513495","https://openalex.org/W2426833868","https://openalex.org/W2955504961","https://openalex.org/W4253535645"],"related_works":["https://openalex.org/W7095441838","https://openalex.org/W2144461742","https://openalex.org/W2887372249","https://openalex.org/W3095442103","https://openalex.org/W2611434197","https://openalex.org/W1969832331","https://openalex.org/W2048285167","https://openalex.org/W3047314584","https://openalex.org/W2038863889","https://openalex.org/W3120814692"],"abstract_inverted_index":{"The":[0],"endocrine":[1],"hormone":[2],"FGF21":[3],"has":[4],"attracted":[5],"considerable":[6],"interest":[7],"as":[8],"a":[9,65,117,130],"potential":[10],"therapeutic":[11,132],"for":[12,129,140],"treating":[13,141],"diabetes":[14,142],"and":[15,34,41,48,84,105,126,143],"obesity.":[16,144],"As":[17],"an":[18,76],"alternative":[19],"to":[20,36,89,134],"the":[21,39,90,100,109],"native":[22],"cytokine,":[23],"we":[24],"generated":[25],"bispecific":[26,78,119],"Avimer":[27,79],"polypeptides":[28],"that":[29],"bind":[30],"with":[31,59,75,93],"high":[32],"affinity":[33],"specificity":[35],"one":[37],"of":[38,103,112,121],"receptor":[40,124],"coreceptor":[42],"pairs":[43],"used":[44],"by":[45],"FGF21,":[46,113],"FGFR1c":[47,104],"\u03b2-Klotho.":[49],"These":[50,95],"Avimers":[51],"exhibit":[52],"FGF21-like":[53],"activity":[54],"in":[55,56,68,107],"vitro":[57],"assays":[58],"potency":[60],"greater":[61],"than":[62],"FGF21.":[63,94],"In":[64],"study":[66],"conducted":[67],"obese":[69],"male":[70],"cynomolgus":[71],"monkeys,":[72],"animals":[73],"treated":[74],"FGFR1c/\u03b2-Klotho":[77],"showed":[80],"improved":[81],"metabolic":[82,110],"parameters":[83],"reduced":[85],"body":[86],"weight":[87],"comparable":[88],"effects":[91,111],"seen":[92],"results":[96],"not":[97],"only":[98],"demonstrate":[99],"essential":[101],"roles":[102],"\u03b2-Klotho":[106],"mediating":[108],"they":[114],"also":[115],"describe":[116],"first":[118],"activator":[120],"this":[122,136],"unique":[123],"complex":[125],"provide":[127],"validation":[128],"novel":[131],"approach":[133],"target":[135],"potentially":[137],"important":[138],"pathway":[139]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}