{"id":"https://openalex.org/W2007948121","doi":"https://doi.org/10.1113/jphysiol.1995.sp020978","title":"Developmental changes in blood\u2010brain barrier potassium permeability in the rat: relation to brain growth.","display_name":"Developmental changes in blood\u2010brain barrier potassium permeability in the rat: relation to brain growth.","publication_year":1995,"publication_date":"1995-10-15","ids":{"openalex":"https://openalex.org/W2007948121","doi":"https://doi.org/10.1113/jphysiol.1995.sp020978","mag":"2007948121","pmid":"https://pubmed.ncbi.nlm.nih.gov/8568682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1156682"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1995.sp020978","doi":"https://doi.org/10.1113/jphysiol.1995.sp020978","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1995.sp020978","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1156682","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024720824","display_name":"Richard F. Keep","orcid":"https://orcid.org/0000-0001-6441-5334","observed_orcids":["https://orcid.org/0000-0001-6441-5334"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R F Keep","raw_affiliation_strings":["Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111889272","display_name":"Steve R. Ennis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S R Ennis","raw_affiliation_strings":["Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055296468","display_name":"Mary E. Beer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Beer","raw_affiliation_strings":["Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112144528","display_name":"A. Lorris Betz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A L Betz","raw_affiliation_strings":["Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.6866,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.68529412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"488","issue":"2","first_page":"439","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9599999785423279},{"id":"https://openalex.org/keywords/potassium-permeability","display_name":"potassium permeability","score":0.9950000047683716},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.7860000133514404},{"id":"https://openalex.org/keywords/brain-growth","display_name":"brain growth","score":0.8790000081062317},{"id":"https://openalex.org/keywords/potassium-influx","display_name":"potassium influx","score":0.6019999980926514},{"id":"https://openalex.org/keywords/fetal-brain","display_name":"fetal brain","score":0.5669999718666077},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.6970000267028809},{"id":"https://openalex.org/keywords/86rb","display_name":"86Rb","score":0.8090000152587891},{"id":"https://openalex.org/keywords/14c-urea","display_name":"14C-urea","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.776650071144104},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.5987443923950195},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.587500810623169},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5597843527793884},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5503940582275391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5145313143730164},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.5133084654808044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49913859367370605},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4866967499256134},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4866939187049866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26994970440864563},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.26877403259277344},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.242843359708786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19990602135658264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17536672949790955},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012414","descriptor_name":"Rubidium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1113/jphysiol.1995.sp020978","doi":"https://doi.org/10.1113/jphysiol.1995.sp020978","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1995.sp020978","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1156682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1156682","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:8568682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8568682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/109983","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/109983","pdf_url":"https://hdl.handle.net/2027.42/109983","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1156682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1156682","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007948121.pdf","grobid_xml":"https://content.openalex.org/works/W2007948121.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W121642688","https://openalex.org/W139953754","https://openalex.org/W1995616783","https://openalex.org/W1998576642","https://openalex.org/W2009830651","https://openalex.org/W2021061460","https://openalex.org/W2029779302","https://openalex.org/W2036502826","https://openalex.org/W2038209949","https://openalex.org/W2039233649","https://openalex.org/W2044661831","https://openalex.org/W2050285850","https://openalex.org/W2052877884","https://openalex.org/W2056436622","https://openalex.org/W2057558873","https://openalex.org/W2059569188","https://openalex.org/W2067733328","https://openalex.org/W2081148102","https://openalex.org/W2081620856","https://openalex.org/W2092078486","https://openalex.org/W2100835385","https://openalex.org/W2106371814","https://openalex.org/W2122753892","https://openalex.org/W2122973260","https://openalex.org/W2126205988","https://openalex.org/W2200070832","https://openalex.org/W2259811235","https://openalex.org/W2400255762","https://openalex.org/W2421694447","https://openalex.org/W2460893177","https://openalex.org/W2473520419","https://openalex.org/W4229954146"],"related_works":["https://openalex.org/W2220351022","https://openalex.org/W91871879","https://openalex.org/W2997493375","https://openalex.org/W47045816","https://openalex.org/W2046610391","https://openalex.org/W1995616783","https://openalex.org/W2013346179","https://openalex.org/W2121698056","https://openalex.org/W7100834597","https://openalex.org/W2014140658"],"abstract_inverted_index":{"1.":[0],"The":[1,29,144],"potassium":[2,130,164,168,178,195],"permeability":[3,90,131,148,169,204],"of":[4,155,162,171],"the":[5,94,127,137,153,159,167,172,182,198,201],"blood-brain":[6],"barrier":[7],"(BBB)":[8],"was":[9,36,66],"determined":[10],"in":[11,38,87,106,129,136,146,152,206],"anaesthetized":[12],"rats":[13],"aged":[14],"between":[15],"21":[16,42],"days":[17,43,81],"gestation":[18,44],"and":[19,158],"adult":[20,173],"using":[21,98],"86Rb+":[22,35],"as":[23],"a":[24,67,115,121,134],"marker":[25],"for":[26,34,112,194,200],"potassium.":[27],"2.":[28],"brain":[30,156,163,187],"influx":[31,107,179],"rate":[32,108,154,161],"constant":[33],"high":[37],"fetal":[39,186],"cortex":[40],"at":[41],"(42.5":[45],"+/-":[46,60,74],"4.3":[47],"microliters":[48,62,76],"g-1":[49,63,77],"min-1)":[50],"but":[51],"had":[52],"decreased":[53],"markedly":[54],"by":[55,79,120],"just":[56],"after":[57,82],"birth":[58],"(12.2":[59],"0.6":[61],"min-1).":[64],"There":[65],"further,":[68],"gradual,":[69],"postnatal":[70,124],"decline":[71,118],"to":[72,109,180],"7.0":[73],"0.3":[75],"min-1":[78],"50":[80],"birth.":[83],"3.":[84],"Developmental":[85],"changes":[86,105,128,145,151],"passive":[88],"BBB":[89,138,147,174,203],"were":[91],"examined":[92],"over":[93],"same":[95],"age":[96],"range":[97],"14[C]urea.":[99],"These":[100],"studies":[101],"showed":[102],"similar":[103],"developmental":[104],"those":[110],"found":[111],"86Rb+.":[113],"Specifically,":[114],"marked":[116],"perinatal":[117],"followed":[119],"more":[122],"gradual":[123],"fall.":[125],"Thus,":[126],"probably":[132],"reflect":[133],"decrease":[135],"paracellular":[139],"leak":[140],"during":[141],"development.":[142,207],"4.":[143],"coincide":[149],"with":[150,185],"growth":[157],"associated":[160,184],"accumulation.":[165],"As":[166],"properties":[170],"would":[175],"provide":[176],"insufficient":[177],"meet":[181],"requirement":[183],"growth,":[188],"it":[189],"is":[190],"suggested":[191],"that":[192],"need":[193],"may":[196],"be":[197],"reason":[199],"greater":[202],"early":[205]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
