{"id":"https://openalex.org/W2007939005","doi":"https://doi.org/10.7326/0003-4819-150-10-200905190-00018","title":"Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk","display_name":"Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk","publication_year":2009,"publication_date":"2009-05-19","ids":{"openalex":"https://openalex.org/W2007939005","doi":"https://doi.org/10.7326/0003-4819-150-10-200905190-00018","mag":"2007939005","pmid":"https://pubmed.ncbi.nlm.nih.gov/19451588"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-150-10-200905190-00018","doi":"https://doi.org/10.7326/0003-4819-150-10-200905190-00018","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-150-10-200905190-00018","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110511201","display_name":"Jeff Gulcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327191685","display_name":"deCODE Genetics (Iceland)","ror":"https://ror.org/04dzdm737","country_code":"IS","type":"company","lineage":["https://openalex.org/I1327191685"]}],"countries":["IS"],"is_corresponding":true,"raw_author_name":"Jeff Gulcher","raw_affiliation_strings":["From deCODE Genetics, Reykjavik 110, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From deCODE Genetics, Reykjavik 110, Iceland","institution_ids":["https://openalex.org/I1327191685"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018239255","display_name":"K\u0101ri Stef\u00e1nsson","orcid":"https://orcid.org/0000-0003-1676-864X","observed_orcids":["https://orcid.org/0000-0003-1676-864X"]},"institutions":[{"id":"https://openalex.org/I1327191685","display_name":"deCODE Genetics (Iceland)","ror":"https://ror.org/04dzdm737","country_code":"IS","type":"company","lineage":["https://openalex.org/I1327191685"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Kari Stefansson","raw_affiliation_strings":["From deCODE Genetics, Reykjavik 110, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From deCODE Genetics, Reykjavik 110, Iceland","institution_ids":["https://openalex.org/I1327191685"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110511201"],"corresponding_institution_ids":["https://openalex.org/I1327191685"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"150","issue":"10","first_page":"736","last_page":"736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosome-9p21-3","display_name":"chromosome 9p21.3","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7059999704360962},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.75},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.43700000643730164},{"id":"https://openalex.org/keywords/traditional-risk-factors","display_name":"traditional risk factors","score":0.5260000228881836},{"id":"https://openalex.org/keywords/genetic-biomarkers","display_name":"genetic biomarkers","score":0.42899999022483826},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6010000109672546},{"id":"https://openalex.org/keywords/lipid-modifying-therapy","display_name":"lipid therapy","score":0.6129999756813049},{"id":"https://openalex.org/keywords/atherosclerosis-risk-in-communities-study","display_name":"Atherosclerosis Risk in Communities Study","score":0.7310000061988831},{"id":"https://openalex.org/keywords/decode-genetics","display_name":"deCODE Genetics","score":0.43799999356269836},{"id":"https://openalex.org/keywords/replication-of-genetic-associations","display_name":"replication of genetic associations","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7012489438056946},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5749861001968384},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5551331043243408},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5082237720489502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4594706892967224},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.44797271490097046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3206222653388977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23595014214515686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16094964742660522},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.1443357765674591},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10465526580810547}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7326/0003-4819-150-10-200905190-00018","doi":"https://doi.org/10.7326/0003-4819-150-10-200905190-00018","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-150-10-200905190-00018","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:19451588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19451588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W69779785","https://openalex.org/W2086098494","https://openalex.org/W2124191974","https://openalex.org/W2132128500"],"related_works":["https://openalex.org/W2161063097","https://openalex.org/W2124191974","https://openalex.org/W205250026","https://openalex.org/W1978089955","https://openalex.org/W2273441544","https://openalex.org/W1984499236","https://openalex.org/W2036741430","https://openalex.org/W4244886918","https://openalex.org/W2139822721","https://openalex.org/W2135369607"],"abstract_inverted_index":{"Letters19":[0],"May":[1,433,461,466],"2009Questions":[2],"About":[3,379,393,408],"Genetic":[4,350,380,394,409],"Variation":[5,351,381,395,410],"in":[6,81,110,124,145,220,240,248,284,382,396,411],"9p21":[7,75,222,383,397,412],"as":[8,115,384,398,413],"a":[9,130,217,385,399,414],"Predictor":[10,386,400,415],"of":[11,89,143,155,184,215,244,282,349,387,401,416,476],"Cardiovascular":[12,176,388,402,417],"RiskJeff":[13],"Gulcher,":[14,22,301],"MD,":[15,20,23,39,302,306],"PhD":[16],"and":[17,36,53,67,181,235,279,297,346,374,427],"Kari":[18,37,304],"Stefansson,":[19,38,305],"PhDJeff":[21],"PhDFrom":[24,40],"deCODE":[25,41,309],"Genetics,":[26,42,310],"Reykjavik":[27,43,311],"110,":[28,44,312],"Iceland.Search":[29,45],"for":[30,46,231,237],"more":[31,47],"papers":[32,48],"by":[33,49,128,473],"this":[34,50,99],"author":[35],"authorAuthor,":[51],"Article,":[52,296],"Disclosure":[54,298],"Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00018":[55],"SectionsAboutFull":[56],"TextPDF":[57],"ToolsAdd":[58],"to":[59,96,112,121,134,224],"favoritesDownload":[60],"CitationsTrack":[61],"CitationsPermissions":[62],"ShareFacebookTwitterLinkedInRedditEmail":[63],"TO":[64],"THE":[65],"EDITOR:Paynter":[66],"colleagues":[68],"(1)":[69],"showed":[70],"that":[71],"the":[72,82,140,146,221,241,245],"widely":[73],"replicated":[74],"genetic":[76,100,185],"risk":[77,80,91,132,136,178,226,229,281,453],"factor":[78,133],"affected":[79],"Women's":[83,149],"Genome":[84,150],"Health":[85,151],"Study,":[86],"largely":[87],"independent":[88],"traditional":[90,135,225],"factors.":[92],"They":[93],"were":[94],"able":[95],"reliably":[97],"measure":[98],"marker":[101],"years":[102,159],"after":[103],"patient":[104],"recruitment":[105],"because":[106],"DNA":[107],"is":[108],"invariant,":[109],"contrast":[111],"such":[113],"biomarkers":[114],"C-reactive":[116,441],"protein":[117],"(CRP).":[118],"The":[119,148],"power":[120],"detect":[122],"improvement":[123],"cardiovascular":[125],"event":[126],"prediction":[127,179],"adding":[129,216],"new":[131],"factors":[137,227,454],"depends":[138],"on":[139,228],"total":[141],"number":[142],"events":[144],"study.":[147,251],"Study":[152],"recruited":[153],"women":[154],"mean":[156],"age":[157],"52":[158],"who":[160],"had":[161],"low":[162],"...References1.":[163],"Paynter":[164,357,421],"NP,":[165],"Chasman":[166,361],"DI,":[167],"Buring":[168,365],"JE,":[169],"Shiffman":[170,368],"D,":[171],"Cook":[172,372,425],"NR,":[173],"Ridker":[174,377,430],"PM.":[175],"disease":[177,234,276],"with":[180],"without":[182],"knowledge":[183],"variation":[186],"at":[187,352],"chromosome":[188],"9p21.3.":[189],"Ann":[190],"Intern":[191],"Med.":[192],"2009;150:65-72.":[193],"[PMID:":[194,291],"19153409]":[195],"LinkGoogle":[196],"Scholar2.":[197],"Brautbar":[198],"A,":[199,209],"Ballantyne":[200],"C,":[201],"Lawson":[202],"K,":[203],"Nambi":[204],"V,":[205],"Chambless":[206],"L,":[207],"Folsom":[208],"et":[210,270],"al.":[211,271],"Abstract":[212],"5050:":[213],"impact":[214],"single":[218],"allele":[219],"locus":[223,277],"classification":[230],"coronary":[232,274],"heart":[233,275],"implications":[236],"lipid-modifying":[238],"therapy":[239],"white":[242],"population":[243],"Atherosclerosis":[246],"Risk":[247,343,389,403,418,457],"Communities":[249],"(ARIC)":[250],"Circulation.":[252],"2008;118":[253],"Suppl":[254],"S-1143.":[255],"Google":[256],"Scholar3.":[257],"Talmud":[258],"PJ,":[259],"Cooper":[260],"JA,":[261],"Palmen":[262],"J,":[263],"Lovering":[264],"R,":[265],"Drenos":[266],"F,":[267],"Hingorani":[268],"AD,":[269],"Chromosome":[272,353],"9p21.3":[273,354],"genotype":[278],"prospective":[280],"CHD":[283],"healthy":[285],"middle-aged":[286],"men.":[287],"Clin":[288],"Chem.":[289],"2008;54:467-74.":[290],"18250146]":[292],"CrossrefMedlineGoogle":[293],"Scholar":[294],"Author,":[295],"InformationAuthors:":[299],"Jeff":[300],"PhD;":[303],"PhDAffiliations:":[307],"From":[308],"Iceland.Disclosures:Employment:":[313],"J.":[314,330],"Gulcher":[315,331],"(deCODE":[316,320,332,336],"Genetics),":[317,333],"K.":[318,334],"Stefansson":[319,335],"Genetics).":[321,337],"Stock":[322],"ownership":[323],"or":[324],"options":[325],"(other":[326],"than":[327],"mutual":[328],"funds):":[329],"PreviousarticleNextarticle":[338],"Advertisement":[339],"FiguresReferencesRelatedDetailsSee":[340],"AlsoCardiovascular":[341],"Disease":[342],"Prediction":[344],"With":[345],"Without":[347],"Knowledge":[348],"Nina":[355,419],"P.":[356,420],",":[358,362,366,369,373,422,426],"Daniel":[359],"I.":[360],"Julie":[363],"E.":[364],"Dov":[367],"Nancy":[370,423],"R.":[371,405,424],"Paul":[375,428],"M.":[376],"Questions":[378,392,407],"Lukasz":[390],"Kiljanek":[391],"John":[404],"Schwarzenbach":[406],"M":[429],"Metrics":[431],"19":[432,460,465],"2009Volume":[434],"150,":[435],"Issue":[436,463],"10":[437],"Page:":[438],"736":[439],"Keywords":[440],"proteins":[442],"Cells":[443],"Cholesterol":[444],"Genetics":[445],"Hypercholesterolemia":[446],"Longitudinal":[447],"studies":[448,456],"Low":[449],"density":[450],"lipoprotein":[451],"Medical":[452],"Prospective":[455],"management":[458],"ePublished:":[459],"2009":[462,467,472],"Published:":[464],"Copyright":[468],"&":[469],"PermissionsCopyright":[470],"\u00a9":[471],"American":[474],"College":[475],"Physicians.":[477],"All":[478],"Rights":[479],"Reserved.PDF":[480],"downloadLoading":[481],"...":[482]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
