{"id":"https://openalex.org/W2007933097","doi":"https://doi.org/10.1089/hgtb.2013.122","title":"A New Method for Generating Insulin-Secreting Cells from Human Pancreatic Epithelial Cells After Islet Isolation Transformed by NeuroD1","display_name":"A New Method for Generating Insulin-Secreting Cells from Human Pancreatic Epithelial Cells After Islet Isolation Transformed by NeuroD1","publication_year":2014,"publication_date":"2014-05-21","ids":{"openalex":"https://openalex.org/W2007933097","doi":"https://doi.org/10.1089/hgtb.2013.122","mag":"2007933097","pmid":"https://pubmed.ncbi.nlm.nih.gov/24845703","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4060820"},"language":"en","primary_location":{"id":"doi:10.1089/hgtb.2013.122","doi":"https://doi.org/10.1089/hgtb.2013.122","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hgtb.2013.122","pdf_url":null,"source":{"id":"https://openalex.org/S2495496942","display_name":"Human Gene Therapy Methods","issn_l":"1946-6536","issn":["1946-6536","1946-6544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4060820","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058185889","display_name":"Masayuki Shimoda","orcid":"https://orcid.org/0000-0002-0338-0008","observed_orcids":["https://orcid.org/0000-0002-0338-0008"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]},{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masayuki Shimoda","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX 75204","Baylor University Medical Center, Dallas, TX 75226","Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX 75204","institution_ids":[]},{"raw_affiliation_string":"Baylor University Medical Center, Dallas, TX 75226","institution_ids":["https://openalex.org/I2802366037"]},{"raw_affiliation_string":"Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103079434","display_name":"Shuyuan Chen","orcid":"https://orcid.org/0009-0002-7751-9073","observed_orcids":["https://orcid.org/0009-0002-7751-9073","https://orcid.org/0009-0001-9610-4503"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuyuan Chen","raw_affiliation_strings":["Baylor University Medical Center, Dallas, TX 75226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor University Medical Center, Dallas, TX 75226","institution_ids":["https://openalex.org/I2802366037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021126434","display_name":"Hirofumi Noguchi","orcid":"https://orcid.org/0000-0002-0880-6805","observed_orcids":["https://orcid.org/0000-0002-0880-6805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirofumi Noguchi","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX 75204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX 75204","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012957428","display_name":"Morihito Takita","orcid":"https://orcid.org/0000-0003-2855-4155","observed_orcids":["https://orcid.org/0000-0003-2855-4155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morihito Takita","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX 75204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX 75204","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Koji Sugimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koji Sugimoto","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX 75204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX 75204","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101901951","display_name":"Takeshi Itoh","orcid":"https://orcid.org/0000-0002-9741-4984","observed_orcids":["https://orcid.org/0000-0002-9741-4984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Itoh","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX 75204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX 75204","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013965216","display_name":"Daisuke Chujo","orcid":"https://orcid.org/0000-0001-7727-6310","observed_orcids":["https://orcid.org/0000-0001-7727-6310"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Chujo","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX 75204","Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX 75204","institution_ids":[]},{"raw_affiliation_string":"Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113646547","display_name":"Shuichi Iwahashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuichi Iwahashi","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX 75204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX 75204","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017433482","display_name":"Bashoo Naziruddin","orcid":"https://orcid.org/0000-0002-0671-9572","observed_orcids":["https://orcid.org/0000-0002-0671-9572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bashoo Naziruddin","raw_affiliation_strings":["Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX 75246"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX 75246","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078861466","display_name":"Marlon F. Levy","orcid":"https://orcid.org/0000-0002-3320-0493","observed_orcids":["https://orcid.org/0000-0002-3320-0493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marlon F. Levy","raw_affiliation_strings":["Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX 75246"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX 75246","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101533619","display_name":"Shinichi Matsumoto","orcid":"https://orcid.org/0000-0001-9959-7756","observed_orcids":["https://orcid.org/0000-0001-9959-7756"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinichi Matsumoto","raw_affiliation_strings":["Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003899849","display_name":"Paul Arthur Grayburn","orcid":"https://orcid.org/0000-0002-9183-1373","observed_orcids":["https://orcid.org/0000-0002-9183-1373"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul A. Grayburn","raw_affiliation_strings":["Baylor University Medical Center, Dallas, TX 75226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor University Medical Center, Dallas, TX 75226","institution_ids":["https://openalex.org/I2802366037"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003899849","https://openalex.org/A5101533619"],"corresponding_institution_ids":["https://openalex.org/I2802366037","https://openalex.org/I4210094012"],"apc_list":null,"apc_paid":null,"fwci":0.33,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63899117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"25","issue":"3","first_page":"206","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-secreting-cells","display_name":"insulin-secreting cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/neurod1","display_name":"NeuroD1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5149999856948853},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/autologous-islet-transplantation","display_name":"autologous islet transplantation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/total-pancreatectomy","display_name":"total pancreatectomy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.3659999966621399},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.8069999814033508},{"id":"https://openalex.org/keywords/allogeneic-islet-transplantation","display_name":"allogeneic islet transplantation","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7009773254394531},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.680883526802063},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6301018595695496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.567152738571167},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5225562453269958},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47877323627471924},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4758010804653168},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4684436619281769},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.46365365386009216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.417472779750824},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35604730248451233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34144824743270874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31454670429229736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3006495237350464},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14889949560165405},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053539","descriptor_name":"Keratin-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/hgtb.2013.122","doi":"https://doi.org/10.1089/hgtb.2013.122","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hgtb.2013.122","pdf_url":null,"source":{"id":"https://openalex.org/S2495496942","display_name":"Human Gene Therapy Methods","issn_l":"1946-6536","issn":["1946-6536","1946-6544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy Methods","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4060820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4060820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Gene Ther Methods","raw_type":"Text"},{"id":"pmid:24845703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24845703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy methods","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4060820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4060820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Gene Ther Methods","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1813294313","display_name":"Establishment of 4th generation of islet isolation and the clinical application","funder_award_id":"24390316","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2517266991","display_name":"A novel NFAT inhibitory peptide (RCAN-11R) provides immunosuppression.","funder_award_id":"26670590","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5910653422","display_name":"Functional MR in Ischemic Cardiomyopathy","funder_award_id":"R01HL072430","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7525984265","display_name":null,"funder_award_id":"HL072430-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320322284","display_name":"Japan IDDM network","ror":"https://ror.org/04aat6738"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W239747312","https://openalex.org/W1010440762","https://openalex.org/W1518831632","https://openalex.org/W1552445206","https://openalex.org/W1966192094","https://openalex.org/W1979928692","https://openalex.org/W1984762682","https://openalex.org/W1990814244","https://openalex.org/W1991533106","https://openalex.org/W1993398930","https://openalex.org/W1997670777","https://openalex.org/W2000123006","https://openalex.org/W2003051170","https://openalex.org/W2006919788","https://openalex.org/W2014844892","https://openalex.org/W2021572386","https://openalex.org/W2024808587","https://openalex.org/W2024915434","https://openalex.org/W2030582796","https://openalex.org/W2031204411","https://openalex.org/W2031631150","https://openalex.org/W2031927586","https://openalex.org/W2034089358","https://openalex.org/W2034540804","https://openalex.org/W2039508080","https://openalex.org/W2045252815","https://openalex.org/W2052721366","https://openalex.org/W2055492712","https://openalex.org/W2078722467","https://openalex.org/W2085639791","https://openalex.org/W2091676818","https://openalex.org/W2108380410","https://openalex.org/W2111807988","https://openalex.org/W2122439512","https://openalex.org/W2129808680","https://openalex.org/W2134661862","https://openalex.org/W2137794809","https://openalex.org/W2142486892","https://openalex.org/W2142542364","https://openalex.org/W2146383332","https://openalex.org/W2154532011","https://openalex.org/W2163921360","https://openalex.org/W2313841264","https://openalex.org/W2328786770"],"related_works":["https://openalex.org/W2021572386","https://openalex.org/W2330871080","https://openalex.org/W2031743699","https://openalex.org/W3111459401","https://openalex.org/W2127259226","https://openalex.org/W2169464066","https://openalex.org/W1991533106","https://openalex.org/W1966192094","https://openalex.org/W2106466349","https://openalex.org/W2092504606"],"abstract_inverted_index":{"The":[0,104,124],"generation":[1,51,209],"of":[2,21,48,85,152],"insulin-secreting":[3,49,122,207,223],"cells":[4,9,156],"from":[5,52,61,66,210],"nonendocrine":[6],"pancreatic":[7],"epithelial":[8],"(NEPEC)":[10],"has":[11],"been":[12],"demonstrated":[13],"for":[14,221,226],"potential":[15,220],"clinical":[16,36,70,178],"use":[17],"in":[18,94,149,160],"the":[19,95,135,139,143,150,177,219],"treatment":[20],"diabetes.":[22],"However,":[23],"previous":[24],"methods":[25],"either":[26],"had":[27],"limited":[28],"efficacy":[29,148,181],"or":[30],"required":[31],"viral":[32,55,118,214],"vectors,":[33],"which":[34],"hinder":[35],"application.":[37],"In":[38,191],"this":[39],"study,":[40],"we":[41],"aimed":[42],"to":[43,79,120,162,203],"establish":[44],"an":[45,112],"efficient":[46,206],"method":[47,116,145,200,217],"cell":[50,208,224],"NEPEC":[53,110,153,212],"without":[54,117,213],"vectors.":[56,215],"We":[57],"used":[58],"nonislet":[59,96],"fractions":[60],"both":[62,227],"research-grade":[63,140],"human":[64,141,211],"pancreata":[65,71,187],"brain-dead":[67],"donors":[68],"and":[69,166,229],"after":[72,169],"total":[73],"pancreatectomy":[74],"with":[75,197],"autologous":[76,230],"islet":[77,231],"transplantation":[78,225],"treat":[80],"chronic":[81,189],"pancreatitis.":[82,190],"It":[83],"is":[84],"note":[86],"that":[87,157],"a":[88,130,163],"few":[89],"islets":[90],"could":[91,101],"be":[92,102],"mingled":[93],"fractions,":[97],"but":[98],"their":[99],"influence":[100],"limited.":[103],"NeuroD1":[105],"gene":[106],"was":[107,126,182],"induced":[108],"into":[109,134,154,172],"using":[111],"effective":[113,144,194],"triple":[114,198],"lipofection":[115,199],"vectors":[119],"generate":[121],"cells.":[123],"differentiation":[125,151,195],"promoted":[127],"by":[128],"adding":[129],"growth":[131],"factor":[132],"cocktail":[133],"culture":[136],"medium.":[137],"Using":[138,176],"pancreata,":[142,179],"showed":[146],"high":[147],"insulin-positive":[155],"secreted":[158],"insulin":[159],"response":[161],"glucose":[164],"challenge":[165],"improved":[167],"diabetes":[168],"being":[170],"transplanted":[171],"diabetic":[173],"athymic":[174],"mice.":[175],"similar":[180],"obtained,":[183],"even":[184],"though":[185],"those":[186],"suffered":[188],"conclusion,":[192],"our":[193],"protocol":[196],"enabled":[201],"us":[202],"achieve":[204],"very":[205],"This":[216],"offers":[218],"supplemental":[222],"allogeneic":[228],"transplantation.":[232]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
