{"id":"https://openalex.org/W2007906385","doi":"https://doi.org/10.1111/j.1349-7006.2010.01663.x","title":"A defucosylated anti\u2010CD317 antibody exhibited enhanced antibody\u2010dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients","display_name":"A defucosylated anti\u2010CD317 antibody exhibited enhanced antibody\u2010dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2007906385","doi":"https://doi.org/10.1111/j.1349-7006.2010.01663.x","mag":"2007906385","pmid":"https://pubmed.ncbi.nlm.nih.gov/20701608","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11158282"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.2010.01663.x","doi":"https://doi.org/10.1111/j.1349-7006.2010.01663.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2010.01663.x","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11158282/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003911767","display_name":"Takahiro Ishiguro","orcid":"https://orcid.org/0000-0001-5618-2710","observed_orcids":["https://orcid.org/0000-0001-5618-2710"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Ishiguro","raw_affiliation_strings":["Pharmaceutical Research Department 3, Chugai Pharmaceutical Co. Ltd, Kanagawa, Japan","Pharmaceutical Research Department 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Department 3, Chugai Pharmaceutical Co. Ltd, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Pharmaceutical Research Department 3","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023248252","display_name":"Shigeto Kawai","orcid":"https://orcid.org/0000-0002-3746-0794","observed_orcids":["https://orcid.org/0000-0002-3746-0794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeto Kawai","raw_affiliation_strings":["Pharmaceutical Research Department 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Department 3","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111794653","display_name":"Kiyoshi Habu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Habu","raw_affiliation_strings":["Genome Antibody Product Research Department, Chugai Pharmaceutical Co. Ltd, Kanagawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Antibody Product Research Department, Chugai Pharmaceutical Co. Ltd, Kanagawa","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055861242","display_name":"Masamichi Sugimoto","orcid":"https://orcid.org/0000-0001-5731-3786","observed_orcids":["https://orcid.org/0000-0001-5731-3786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masamichi Sugimoto","raw_affiliation_strings":["Pharmaceutical Research Department 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Department 3","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000390196","display_name":"Hirotake Shiraiwa","orcid":"https://orcid.org/0000-0001-6439-7682","observed_orcids":["https://orcid.org/0000-0001-6439-7682"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotake Shiraiwa","raw_affiliation_strings":["Genome Antibody Product Research Department, Chugai Pharmaceutical Co. Ltd, Kanagawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Antibody Product Research Department, Chugai Pharmaceutical Co. Ltd, Kanagawa","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110106170","display_name":"Shigeyuki Iijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyuki Iijima","raw_affiliation_strings":["Genome Antibody Product Research Department, Chugai Pharmaceutical Co. Ltd, Kanagawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Antibody Product Research Department, Chugai Pharmaceutical Co. Ltd, Kanagawa","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001924375","display_name":"Shuji Ozaki","orcid":"https://orcid.org/0000-0002-9808-0752","observed_orcids":["https://orcid.org/0000-0002-9808-0752"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Ozaki","raw_affiliation_strings":["Tokushima University, Tokushima","Tokushima Univ., Tokushima"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima University, Tokushima","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima Univ., Tokushima","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004644505","display_name":"Toshio Matsumoto","orcid":"https://orcid.org/0000-0002-0618-0941","observed_orcids":["https://orcid.org/0000-0002-0618-0941"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Matsumoto","raw_affiliation_strings":["Tokushima University, Tokushima","Tokushima Univ., Tokushima"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima University, Tokushima","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima Univ., Tokushima","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108485594","display_name":"Hisafumi Yamada\u2010Okabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hisafumi Yamada\u2010Okabe","raw_affiliation_strings":["Research Planning and Coordination Department, Chugai Pharmaceutical Co. Ltd, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Planning and Coordination Department, Chugai Pharmaceutical Co. Ltd, Shizuoka, Japan","institution_ids":["https://openalex.org/I4405254473"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108485594"],"corresponding_institution_ids":["https://openalex.org/I4405254473"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":null,"fwci":1.5422,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.81201034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"101","issue":"10","first_page":"2227","last_page":"2233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/n-glycans","display_name":"N-glycans","score":0.8619999885559082},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.9474455714225769},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7786515951156616},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6795646548271179},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5860905051231384},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5697776079177856},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5343828201293945},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.5149782299995422},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.49122852087020874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.463058203458786},{"id":"https://openalex.org/C2777762822","wikidata":"https://www.wikidata.org/wiki/Q5507035","display_name":"Fucosyltransferase","level":3,"score":0.4581943452358246},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4299238920211792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37073832750320435},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33871936798095703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24452751874923706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20744529366493225},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1974165141582489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08655992150306702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074010","descriptor_name":"Bone Marrow Stromal Antigen 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1349-7006.2010.01663.x","doi":"https://doi.org/10.1111/j.1349-7006.2010.01663.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2010.01663.x","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmid:20701608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20701608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11158282","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11158282/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11158282","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11158282/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W27112539","https://openalex.org/W1965962344","https://openalex.org/W1974798389","https://openalex.org/W1991650736","https://openalex.org/W1995118292","https://openalex.org/W2000910762","https://openalex.org/W2010458160","https://openalex.org/W2011061970","https://openalex.org/W2035433348","https://openalex.org/W2044360617","https://openalex.org/W2055465436","https://openalex.org/W2060439989","https://openalex.org/W2062608060","https://openalex.org/W2064747304","https://openalex.org/W2067376871","https://openalex.org/W2073860679","https://openalex.org/W2079579628","https://openalex.org/W2084136419","https://openalex.org/W2086063536","https://openalex.org/W2087881430","https://openalex.org/W2110881937","https://openalex.org/W2115571948","https://openalex.org/W2122080125","https://openalex.org/W2122584026","https://openalex.org/W2122618533","https://openalex.org/W2127214162","https://openalex.org/W2129658913","https://openalex.org/W2130930654","https://openalex.org/W2137354517","https://openalex.org/W2143562636","https://openalex.org/W2152155460","https://openalex.org/W2156750419","https://openalex.org/W2282610461"],"related_works":["https://openalex.org/W2081867678","https://openalex.org/W2772073087","https://openalex.org/W2040252279","https://openalex.org/W2581486206","https://openalex.org/W2282610461","https://openalex.org/W2011061970","https://openalex.org/W2086063536","https://openalex.org/W2762975811","https://openalex.org/W2115571948","https://openalex.org/W2584364734"],"abstract_inverted_index":{"The":[0,104,183],"humanized":[1],"monoclonal":[2,132],"antibody":[3,206],"(mAb)":[4,134],"against":[5,58,85,115,207],"CD317":[6],"antigen":[7],"(anti-HM1.24":[8],"antibody;":[9],"AHM),":[10],"which":[11],"is":[12],"highly":[13],"expressed":[14],"on":[15],"multiple":[16],"myeloma":[17,71],"(MM),":[18],"induces":[19],"antibody-dependent":[20],"cellular":[21],"cytotoxicity":[22],"(ADCC).":[23],"However,":[24],"the":[25,31,94,108,139,158,162,167,178,210],"antitumor":[26],"activity":[27,84],"of":[28,78,88,96,110,157,177],"AHM":[29,45,65,101,111,164,198],"in":[30,69,93,147,161,209],"clinical":[32,51,211],"setting":[33],"has":[34],"not":[35],"been":[36],"clearly":[37],"demonstrated.":[38],"In":[39],"this":[40],"study,":[41],"we":[42,137],"produced":[43,68,165,187],"defucosylated":[44,131,163,188,197],"and":[46],"evaluated":[47],"its":[48],"potency":[49,109],"for":[50,135],"application":[52],"by":[53,125,152,166],"performing":[54],"autologous":[55,97],"ADCC":[56,83,114],"assays":[57],"primary":[59,90,116],"MM":[60,91,117,208],"cells":[61,73,92,118,185],"from":[62],"patients.":[63],"Defucosylated":[64],"that":[66,107,142,173,195],"was":[67,119,122,180],"rat":[70],"YB2/0":[72],"expressing":[74],"a":[75,144,148,174,202],"low":[76],"level":[77],"fucosyltransferase":[79],"(FUT8)":[80],"showed":[81,172],"significant":[82],"three":[86],"out":[87],"six":[89],"presence":[95],"PBMC,":[98],"whereas":[99],"conventional":[100],"did":[102],"not.":[103],"results":[105,193],"indicate":[106],"to":[112],"induce":[113],"insufficient,":[120],"but":[121],"significantly":[123],"augmented":[124],"defucosylation.":[126],"To":[127],"generate":[128],"more":[129],"homogenous":[130],"antibodies":[133],"fermentation,":[136],"disrupted":[138],"GFT":[140],"gene":[141],"encodes":[143],"GDP-fucose":[145],"transporter":[146],"CHO/DXB11":[149],"cell":[150,170],"line":[151,171],"sequential":[153],"homologous":[154],"recombination.":[155],"Analysis":[156],"N-linked":[159],"oligosaccharide":[160,179],"established":[168],"GFT(-/-)CHO":[169],"majority":[175],"(93.4%)":[176],"fucose":[181],"free.":[182],"GFT(-/-)":[184],"stably":[186],"mAb":[189],"over":[190],"passages.":[191],"These":[192],"demonstrate":[194],"GTF(-/-)CHO-produced":[196],"(GFTKO-AHM)":[199],"will":[200],"be":[201],"promising":[203],"new":[204],"therapeutic":[205],"setting.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}