{"id":"https://openalex.org/W2007904803","doi":"https://doi.org/10.1016/0012-1606(86)90359-3","title":"Maintenance of murine oocyte meiotic arrest: Uptake and metabolism of hypoxanthine and adenosine by cumulus cell-enclosed and denuded oocytes","display_name":"Maintenance of murine oocyte meiotic arrest: Uptake and metabolism of hypoxanthine and adenosine by cumulus cell-enclosed and denuded oocytes","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W2007904803","doi":"https://doi.org/10.1016/0012-1606(86)90359-3","mag":"2007904803","pmid":"https://pubmed.ncbi.nlm.nih.gov/2875006"},"language":"en","primary_location":{"id":"doi:10.1016/0012-1606(86)90359-3","doi":"https://doi.org/10.1016/0012-1606(86)90359-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0012-1606(86)90359-3","pdf_url":null,"source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen M. Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M. Downs","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine 04609 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine 04609 USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103496903","display_name":"Douglas L. Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas L. Coleman","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine 04609 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine 04609 USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110191925","display_name":"John J. Eppig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Eppig","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine 04609 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine 04609 USA","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":5.0884,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.96266268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"117","issue":"1","first_page":"174","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.8629999756813049},{"id":"https://openalex.org/keywords/oocytes","display_name":"oocytes","score":0.7179999947547913},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.8980000019073486},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cumulus-cells","display_name":"cumulus cells","score":0.6779999732971191},{"id":"https://openalex.org/keywords/mycophenolic-acid","display_name":"mycophenolic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/2-chloroadenosine","display_name":"2-chloroadenosine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/xanthine","display_name":"xanthine","score":0.6320000290870667},{"id":"https://openalex.org/keywords/guanine","display_name":"guanine","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.9363687634468079},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.7993797659873962},{"id":"https://openalex.org/C2777610669","wikidata":"https://www.wikidata.org/wiki/Q422564","display_name":"Inosine","level":3,"score":0.7158883810043335},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.6775273084640503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5130537748336792},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.49819016456604004},{"id":"https://openalex.org/C2778928357","wikidata":"https://www.wikidata.org/wiki/Q5194195","display_name":"Cumulus oophorus","level":4,"score":0.46832969784736633},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4400535225868225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4030883312225342},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.09624788165092468},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.03984034061431885}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007042","descriptor_name":"Hypoxanthines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007168","descriptor_name":"IMP Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007288","descriptor_name":"Inosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009173","descriptor_name":"Mycophenolic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015762","descriptor_name":"2-Chloroadenosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0012-1606(86)90359-3","doi":"https://doi.org/10.1016/0012-1606(86)90359-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0012-1606(86)90359-3","pdf_url":null,"source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},{"id":"pmid:2875006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2875006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb1980_1989-1754","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb1980_1989/755","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 1980 - 1989","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2331213927","display_name":null,"funder_award_id":"HD 06650","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7184565415","display_name":"REGULATION OF MAMMALIAN OOCYTE DEVELOPMENT","funder_award_id":"R01HD020575","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7820853856","display_name":"HEREDITARY DIABETES IN THE MOUSE","funder_award_id":"R01AM014461","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1489790705","https://openalex.org/W1585750445","https://openalex.org/W1608818562","https://openalex.org/W1963832918","https://openalex.org/W1976220201","https://openalex.org/W1993444917","https://openalex.org/W1996826126","https://openalex.org/W2001369764","https://openalex.org/W2010184839","https://openalex.org/W2013765982","https://openalex.org/W2050017836","https://openalex.org/W2053299519","https://openalex.org/W2090276649","https://openalex.org/W2096696781","https://openalex.org/W2103750154","https://openalex.org/W2107003449","https://openalex.org/W2149951962","https://openalex.org/W2154737050","https://openalex.org/W2295074165","https://openalex.org/W2410961661","https://openalex.org/W2415070932"],"related_works":["https://openalex.org/W1594898681","https://openalex.org/W2170530908","https://openalex.org/W2086065239","https://openalex.org/W2034342456","https://openalex.org/W2050624552","https://openalex.org/W2154737050","https://openalex.org/W2148996094","https://openalex.org/W2412846926","https://openalex.org/W2057684436","https://openalex.org/W2370943993"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}