{"id":"https://openalex.org/W2007889243","doi":"https://doi.org/10.1046/j.1365-2958.1996.281397.x","title":"Overexpression of the mexC\u2013mexD\u2013oprJ efflux operon in nfxB\u2010type multidrug\u2010resistant strains of Pseudomonas aeruginosa","display_name":"Overexpression of the mexC\u2013mexD\u2013oprJ efflux operon in nfxB\u2010type multidrug\u2010resistant strains of Pseudomonas aeruginosa","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2007889243","doi":"https://doi.org/10.1046/j.1365-2958.1996.281397.x","mag":"2007889243","pmid":"https://pubmed.ncbi.nlm.nih.gov/8878035"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2958.1996.281397.x","doi":"https://doi.org/10.1046/j.1365-2958.1996.281397.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.1996.281397.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2007889243"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054659015","display_name":"Keith Poole","orcid":"https://orcid.org/0000-0002-0848-6493","observed_orcids":["https://orcid.org/0000-0002-0848-6493"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Keith Poole","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada. poolek@post.queensu.ca","Dept. of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada. poolek@post.queensu.ca","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Dept. of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084045447","display_name":"Naomasa Gotoh","orcid":"https://orcid.org/0000-0002-9800-6843","observed_orcids":["https://orcid.org/0000-0002-9800-6843"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Naomasa Gotoh","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106182881","display_name":"Hideto Tsujimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Hideto Tsujimoto","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111933990","display_name":"Qixun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Qixun Zhao","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069541700","display_name":"\u548c\u7530\u660e\u4e45","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Akihisa Wada","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tetsuo Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Tetsuo Yamasaki","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007010436","display_name":"Sh\u00e1di Neshat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Shadi Neshat","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014960615","display_name":"Jun\u2010ichi Yamagishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Jun\u2010ichi Yamagishi","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013787352","display_name":"Xian-Zhi Li","orcid":"https://orcid.org/0000-0003-1722-3254","observed_orcids":["https://orcid.org/0000-0003-1722-3254"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Xian\u2010Zhi Li","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111600764","display_name":"Takeshi Nishino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","JP","US"],"is_corresponding":false,"raw_author_name":"Takeshi Nishino","raw_affiliation_strings":["1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","University of California, Berkeley, Berkeley, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1\n                Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada, K7l 3N6, Canada. \n              \n                \n                  2\n                Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607, Japan. \n              \n                \n                  3\n                Discovery Research Laboratories II, Dainippon Phar-maceutical Company, Enoki, Suita/Osaka 564, Japan. \n              \n                \n                  4\n                \n              Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I25998863","https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of California, Berkeley, Berkeley, United States","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054659015"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":15.1799,"has_fulltext":false,"cited_by_count":453,"citation_normalized_percentile":{"value":0.99752628,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"21","issue":"4","first_page":"713","last_page":"725"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mexab-oprm-efflux-pump","display_name":"MexAB-OprM efflux pump","score":0.7559999823570251},{"id":"https://openalex.org/keywords/efflux-pump-overexpression","display_name":"efflux pump overexpression","score":0.6790000200271606},{"id":"https://openalex.org/keywords/repressors","display_name":"repressors","score":0.4959999918937683},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.6079999804496765},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.7089999914169312},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.5640000104904175},{"id":"https://openalex.org/keywords/n-terminal-sequence","display_name":"N-terminal sequence","score":0.4970000088214874},{"id":"https://openalex.org/keywords/divergent-transcription","display_name":"divergent transcription","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9171527624130249},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8746967315673828},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.7078585028648376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5600916743278503},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.5041865110397339},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4157216548919678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3835605978965759},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3268299698829651},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.22793671488761902},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2235710322856903}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002258","descriptor_name":"Carbonyl Cyanide m-Chlorophenyl Hydrazone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009643","descriptor_name":"Norfloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2958.1996.281397.x","doi":"https://doi.org/10.1046/j.1365-2958.1996.281397.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.1996.281397.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},{"id":"pmid:8878035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8878035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306168","display_name":"Cystic Fibrosis Foundation","ror":"https://ror.org/00ax59295"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2154392088","https://openalex.org/W2043698490","https://openalex.org/W1879483605","https://openalex.org/W2138956870","https://openalex.org/W2126813175","https://openalex.org/W2383582549","https://openalex.org/W2157548667","https://openalex.org/W2995351550","https://openalex.org/W2064367478","https://openalex.org/W2130443164"],"abstract_inverted_index":{"OprJ,":[0],"overproduced":[1,11],"in":[2,12,101,135,231,234,238,248,279,324],"nfxB":[3,204,255,259,271,282,306],"multidrug-resistant":[4,14],"strains":[5,307],"of":[6,29,46,72,89,91,118,123,145,148,173,177,191,197,202,213,220,263,275,286,305,312,319],"Pseudomonas":[7],"aeruginosa,":[8],"and":[9,42,58,81,156,167,179,215,245],"OprK,":[10],"the":[13,30,43,73,98,115,119,138,200,203,209,216,239,253,269,302],"strain":[15,140,221],"K385,":[16],"were":[17,67],"demonstrated":[18],"to":[19,69,114,187,225,310],"be":[20],"immunologically":[21],"cross-reactive":[22],"using":[23],"an":[24,130,313],"OprJ-specific":[25],"monoclonal":[26],"antibody.":[27],"Treatment":[28],"purified":[31],"proteins":[32],"with":[33,129,152,267],"trypsin":[34,48],"or":[35],"chymotrypsin":[36],"yielded":[37],"virtually":[38],"indistinguishable":[39],"digestion":[40],"patterns,":[41],"N-terminal":[44,63],"sequence":[45],"two":[47],"fragments":[49,93],"was":[50,97,160,185,223,250],"identical":[51],"for":[52,133],"both":[53],"proteins,":[54],"indicating":[55,290],"that":[56,95,258,291,301],"OprJ":[57,214,243],"OprK":[59],"share":[60],"identity.":[61],"The":[62,107,165],"amino":[64],"acid":[65],"sequences":[66],"used":[68],"facilitate":[70],"cloning":[71],"oprJ":[74,96,168],"gene":[75,100,110,205,272],"on":[76],"a":[77,82,102,146,174,189,228,235,261,276,287,320],"5kbp":[78],"Kpnl":[79],"fragment":[80],"10":[83],"kbp":[84],"BamHl":[85],"fragment.":[86],"Nucleotide":[87],"sequencing":[88],"portions":[90],"these":[92],"revealed":[94,199],"terminal":[99],"putative":[103,171],"three-gene":[104],"operon,":[105,315],"mexC-mexD-oprJ.":[106],"predicted":[108,186,240],"mexC-mexD-oprJ":[109,134,264],"products":[111,169],"exhibit":[112],"homology":[113],"MexA-MexB-OprM":[116],"components":[117,318],"multidrug-resistance":[120],"efflux":[121,210,314,322],"pump":[122,323],"P.":[124,325],"aeruginosa":[125],"(43-46%":[126],"identity).":[127],"Consistent":[128,266],"implied":[131],"role":[132],"drug":[136,158],"efflux,":[137],"mexC-mexD-oprJ-hyperexpressing":[139],"K385":[141,222,249],"showed":[142],"reduced":[143],"accumulation":[144],"variety":[147],"antibiotics":[149],"as":[150],"compared":[151],"its":[153,295],"parent":[154],"strain,":[155],"this":[157],"'exclusion'":[159],"abrogated":[161],"by":[162,252],"energy":[163],"inhibitors.":[164],"mexC":[166,198],"are":[170],"lipoproteins":[172],"molecular":[175],"mass":[176],"40,707":[178],"51,742":[180],"Da,":[181],"respectively,":[182],"while":[183],"mexD":[184],"encode":[188],"protein":[190],"111":[192],"936":[193],"Da.":[194],"Sequencing":[195],"upstream":[196],"presence":[201],"transcribed":[206],"divergently":[207],"from":[208,227],"genes.":[211],"Overproduction":[212],"attendant":[217],"multiple-antibiotic":[218],"resistance":[219,247,304],"shown":[224],"result":[226],"point":[229],"mutation":[230],"nfxB,":[232],"resulting":[233],"H87-->R":[236],"change":[237],"NfxB":[241,292],"polypeptide.":[242],"overproduction":[244],"multidrug":[246,303],"reversed":[251],"cloned":[254,270],"gene,":[256],"suggesting":[257],"encodes":[260],"repressor":[262],"expression.":[265,297],"this,":[268],"repressed":[273,284],"synthesis":[274],"mexC-lacZ":[277],"fusion":[278],"Escherichia":[280],"coli.":[281],"also":[283],"expression":[285],"nfxB-lacZ":[288],"fusion,":[289],"negatively":[293],"regulates":[294],"own":[296],"These":[298],"data":[299],"indicate":[300],"is":[308],"due":[309],"overexpression":[311],"mexC-mexD-oprJ,":[316],"encoding":[317],"second":[321],"aeruginosa.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}