{"id":"https://openalex.org/W2007871032","doi":"https://doi.org/10.1186/1755-8794-4-6","title":"Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer","display_name":"Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer","publication_year":2011,"publication_date":"2011-01-12","ids":{"openalex":"https://openalex.org/W2007871032","doi":"https://doi.org/10.1186/1755-8794-4-6","mag":"2007871032","pmid":"https://pubmed.ncbi.nlm.nih.gov/21226949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3032645"},"language":"en","primary_location":{"id":"doi:10.1186/1755-8794-4-6","doi":"https://doi.org/10.1186/1755-8794-4-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8794-4-6","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-4-6","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-4-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066945562","display_name":"Kenneth S Kompass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth S Kompass","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, USA","Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California San Francisco, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035070420","display_name":"John S. Witte","orcid":"https://orcid.org/0000-0003-0146-1434","observed_orcids":["https://orcid.org/0000-0003-0146-1434"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John S Witte","raw_affiliation_strings":["Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA","Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California San Francisco, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035070420"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.9199,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85317363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-co-expression","display_name":"gene co-expression","score":0.8600000143051147},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.8420000076293945},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.796999990940094},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.7148164510726929},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6608257293701172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6437626481056213},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.6142448782920837},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.6036327481269836},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.5874360799789429},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5769521594047546},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.5060595870018005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4734708368778229},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35892781615257263},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3282890319824219},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32637226581573486},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18784278631210327},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1803554892539978},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17545828223228455},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1755-8794-4-6","doi":"https://doi.org/10.1186/1755-8794-4-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8794-4-6","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-4-6","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3032645","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3032645","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Genomics","raw_type":"Text"},{"id":"pmid:21226949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21226949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genomics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d15e5c639f7e4beaa1aed55af49332cd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d15e5c639f7e4beaa1aed55af49332cd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genomics, Vol 4, Iss 1, p 6 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1755-8794-4-6","doi":"https://doi.org/10.1186/1755-8794-4-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8794-4-6","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-4-6","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3389368987","display_name":"Genetic Epidemiology of Prostate Cancer Risk and Progression","funder_award_id":"R01CA088164","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007871032.pdf","grobid_xml":"https://content.openalex.org/works/W2007871032.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W204855579","https://openalex.org/W228277696","https://openalex.org/W288838515","https://openalex.org/W1493217831","https://openalex.org/W1966901658","https://openalex.org/W1969761972","https://openalex.org/W1975332071","https://openalex.org/W1977840477","https://openalex.org/W1987157665","https://openalex.org/W1988871238","https://openalex.org/W1991620635","https://openalex.org/W2004275852","https://openalex.org/W2006386290","https://openalex.org/W2009445331","https://openalex.org/W2012808741","https://openalex.org/W2014347464","https://openalex.org/W2020799240","https://openalex.org/W2028521269","https://openalex.org/W2029276959","https://openalex.org/W2030951629","https://openalex.org/W2032780125","https://openalex.org/W2035117693","https://openalex.org/W2041835558","https://openalex.org/W2043842514","https://openalex.org/W2049820652","https://openalex.org/W2050383354","https://openalex.org/W2060705109","https://openalex.org/W2061295375","https://openalex.org/W2064181852","https://openalex.org/W2067896070","https://openalex.org/W2069733150","https://openalex.org/W2073075206","https://openalex.org/W2074693857","https://openalex.org/W2081542461","https://openalex.org/W2085458327","https://openalex.org/W2086321869","https://openalex.org/W2090808827","https://openalex.org/W2091901410","https://openalex.org/W2094248448","https://openalex.org/W2102088808","https://openalex.org/W2102241087","https://openalex.org/W2103017472","https://openalex.org/W2103474364","https://openalex.org/W2104101394","https://openalex.org/W2108069662","https://openalex.org/W2110065044","https://openalex.org/W2115521447","https://openalex.org/W2116765321","https://openalex.org/W2117007075","https://openalex.org/W2119043225","https://openalex.org/W2120418776","https://openalex.org/W2121195642","https://openalex.org/W2124309131","https://openalex.org/W2134537390","https://openalex.org/W2135221645","https://openalex.org/W2137499573","https://openalex.org/W2139807849","https://openalex.org/W2144977440","https://openalex.org/W2145613550","https://openalex.org/W2147925490","https://openalex.org/W2148643788","https://openalex.org/W2148860875","https://openalex.org/W2150953873","https://openalex.org/W2154972202","https://openalex.org/W2156066129","https://openalex.org/W2156925439","https://openalex.org/W2157795344","https://openalex.org/W2160697532","https://openalex.org/W2161073810","https://openalex.org/W2161640106","https://openalex.org/W2167120442","https://openalex.org/W2167190345","https://openalex.org/W2168312688","https://openalex.org/W2328901916","https://openalex.org/W2396939542","https://openalex.org/W2415944205","https://openalex.org/W4200531859","https://openalex.org/W4255655703","https://openalex.org/W4294107304","https://openalex.org/W7099616233"],"related_works":["https://openalex.org/W1987045471","https://openalex.org/W4414877438","https://openalex.org/W3083602581","https://openalex.org/W2939962291","https://openalex.org/W7082381522","https://openalex.org/W3196524966","https://openalex.org/W4381059386","https://openalex.org/W2109336521","https://openalex.org/W2995585026","https://openalex.org/W7099188382"],"abstract_inverted_index":{"BACKGROUND:":[0],"Expression":[1],"quantitative":[2,52],"trait":[3,53],"loci":[4],"(eQTL)":[5],"studies":[6],"have":[7],"helped":[8],"identify":[9,33],"the":[10,17,34,43,90,110,119,126,159],"genetic":[11],"determinants":[12],"of":[13,37,45,59,64,82,98,103,125,128,142,158],"gene":[14,39,143],"expression.":[15],"Understanding":[16],"potential":[18],"interacting":[19],"mechanisms":[20,87],"underlying":[21],"such":[22],"findings,":[23],"however,":[24],"is":[25,161],"challenging.":[26],"METHODS:":[27],"We":[28],"describe":[29],"a":[30,60,67,80,92,95,101,139],"method":[31,78,160],"to":[32,79],"trans-acting":[35],"drivers":[36],"multiple":[38],"co-expression,":[40],"which":[41],"reflects":[42],"action":[44],"regulatory":[46,86],"molecules.":[47],"This":[48,107],"method-termed":[49],"co-regulatory":[50],"expression":[51],"locus":[54,96],"(creQTL)":[55],"mapping-allows":[56],"for":[57,151],"evaluation":[58],"more":[61],"focused":[62],"set":[63],"phenotypes":[65],"within":[66],"clear":[68],"biological":[69],"context":[70],"than":[71],"conventional":[72],"eQTL":[73],"mapping.":[74],"RESULTS:":[75],"Applying":[76],"this":[77],"study":[81],"endometrial":[83],"cancer":[84],"revealed":[85],"supported":[88],"by":[89,113],"literature:":[91],"creQTL":[93,136],"between":[94],"upstream":[97],"STARD13/DLC2":[99],"and":[100,118,145],"group":[102],"seven":[104],"IFN\u03b2-induced":[105,116],"genes.":[106],"suggests":[108],"that":[109,135],"Rho-GTPase":[111],"encoded":[112],"STARD13":[114],"regulates":[115],"genes":[117],"DNA":[120],"damage":[121],"response.":[122],"CONCLUSIONS:":[123],"Because":[124],"importance":[127],"IFN\u03b2":[129],"in":[130],"cancer,":[131],"our":[132],"results":[133],"suggest":[134],"may":[137,146],"provide":[138],"finer":[140],"picture":[141],"regulation":[144],"reveal":[147],"additional":[148],"molecular":[149],"targets":[150],"intervention.":[152],"An":[153],"open":[154],"source":[155],"R":[156],"implementation":[157],"available":[162],"at":[163],"http://sites.google.com/site/kenkompass/.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
