{"id":"https://openalex.org/W2007868209","doi":"https://doi.org/10.1073/pnas.0709264104","title":"Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function","display_name":"Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function","publication_year":2007,"publication_date":"2007-11-27","ids":{"openalex":"https://openalex.org/W2007868209","doi":"https://doi.org/10.1073/pnas.0709264104","mag":"2007868209","pmid":"https://pubmed.ncbi.nlm.nih.gov/18040044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2148310"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0709264104","doi":"https://doi.org/10.1073/pnas.0709264104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0709264104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2148310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032761657","display_name":"Kausik Chattopadhyay","orcid":"https://orcid.org/0000-0001-8529-9475","observed_orcids":["https://orcid.org/0000-0001-8529-9475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kausik Chattopadhyay","raw_affiliation_strings":["Departments of *Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088864600","display_name":"Udupi Anantharamachar Ramagopal","orcid":"https://orcid.org/0000-0003-1045-9838","observed_orcids":["https://orcid.org/0000-0003-1045-9838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Udupi A. Ramagopal","raw_affiliation_strings":["Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007758330","display_name":"Arunika Mukhopadhaya","orcid":"https://orcid.org/0000-0003-2121-7885","observed_orcids":["https://orcid.org/0000-0003-2121-7885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arunika Mukhopadhaya","raw_affiliation_strings":["Departments of *Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012887043","display_name":"Vladimir\u00a0N. Malashkevich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir N. Malashkevich","raw_affiliation_strings":["Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085145316","display_name":"Teresa P. DiLorenzo","orcid":"https://orcid.org/0000-0003-4337-3598","observed_orcids":["https://orcid.org/0000-0003-4337-3598"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa P. DiLorenzo","raw_affiliation_strings":["Departments of *Microbiology and Immunology,","Medicine (Division of Endocrinology), Albert Einstein College of Medicine, Bronx, NY 10461","Departments of *Microbiology and Immunology,; Medicine (Division of Endocrinology), Albert Einstein College of Medicine, Bronx, NY 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Microbiology and Immunology,","institution_ids":[]},{"raw_affiliation_string":"Medicine (Division of Endocrinology), Albert Einstein College of Medicine, Bronx, NY 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Departments of *Microbiology and Immunology,; Medicine (Division of Endocrinology), Albert Einstein College of Medicine, Bronx, NY 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010967667","display_name":"Michael D. Brenowitz","orcid":"https://orcid.org/0000-0003-0048-1716","observed_orcids":["https://orcid.org/0000-0003-0048-1716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Brenowitz","raw_affiliation_strings":["Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112131090","display_name":"Stanley G. Nathenson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanley G. Nathenson","raw_affiliation_strings":["Cell Biology,","Departments of *Microbiology and Immunology,","Cell Biology,; Departments of *Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology,","institution_ids":[]},{"raw_affiliation_string":"Departments of *Microbiology and Immunology,","institution_ids":[]},{"raw_affiliation_string":"Cell Biology,; Departments of *Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006013523","display_name":"Steven C. Almo","orcid":"https://orcid.org/0000-0003-2591-5234","observed_orcids":["https://orcid.org/0000-0003-2591-5234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven C. Almo","raw_affiliation_strings":["Biochemistry,","Physiology and Biophysics,","Biochemistry,; Physiology and Biophysics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"Physiology and Biophysics,","institution_ids":[]},{"raw_affiliation_string":"Biochemistry,; Physiology and Biophysics,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6805,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.83483632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"104","issue":"49","first_page":"19452","last_page":"19457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.19679999351501465,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0746999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gitrl","display_name":"GITRL","score":0.7919999957084656},{"id":"https://openalex.org/keywords/gitr","display_name":"GITR","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tnf-family","display_name":"TNF family","score":0.7429999709129333},{"id":"https://openalex.org/keywords/protein-trimerization","display_name":"protein trimerization","score":0.6190000176429749},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ectodomain-structure","display_name":"ectodomain structure","score":0.6200000047683716},{"id":"https://openalex.org/keywords/signaling-pathway-regulation","display_name":"signaling regulation","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C1009742","wikidata":"https://www.wikidata.org/wiki/Q5333998","display_name":"Ectodomain","level":3,"score":0.9785733222961426},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.604964017868042},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6023914813995361},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5898137092590332},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5869830250740051},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5461127161979675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4834526479244232},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4537981450557709},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.44533613324165344},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.44054895639419556},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.41452616453170776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3333459496498108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26420724391937256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17612570524215698},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.1403314173221588},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017475","descriptor_name":"Receptors, Nerve Growth Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053450","descriptor_name":"Glucocorticoid-Induced TNFR-Related Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0709264104","doi":"https://doi.org/10.1073/pnas.0709264104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0709264104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2148310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2148310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18040044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18040044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2148310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2148310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3445186599","display_name":"Preservation & Replacement of Beta Cells in IDDM","funder_award_id":"P01DK052956","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3560330250","display_name":"CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes","funder_award_id":"R21DK077500","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4405391965","display_name":null,"funder_award_id":"AI07289","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G547077256","display_name":"Mechanisms of beta2-microglubin in Autoimmune Diabetes","funder_award_id":"R01DK065247","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G630845642","display_name":null,"funder_award_id":"DK20541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7040710722","display_name":"Molecular and Structural Basis for T Cell Costimulation","funder_award_id":"R56AI007289","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G788956770","display_name":"Diabetes Research and Training Center","funder_award_id":"P60DK020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8071500246","display_name":"Antigens Recognized by CD8+ T Cells in Type 1 Diabetes","funder_award_id":"R01DK064315","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8623839475","display_name":"Molecular and Structural Basis for T Cell Costimulation","funder_award_id":"R01AI007289","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000208100","display_name":null,"funder_award_id":"AI07289","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900974","display_name":"NYR-Diabetes Research Center (NYR-DRC)","funder_award_id":"P30DK020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1573145410","https://openalex.org/W1627704003","https://openalex.org/W1960197119","https://openalex.org/W1987772726","https://openalex.org/W1999227421","https://openalex.org/W2018572383","https://openalex.org/W2019471689","https://openalex.org/W2033746426","https://openalex.org/W2038163496","https://openalex.org/W2039038215","https://openalex.org/W2046382304","https://openalex.org/W2051989434","https://openalex.org/W2066015053","https://openalex.org/W2072380594","https://openalex.org/W2077143212","https://openalex.org/W2080831004","https://openalex.org/W2088422105","https://openalex.org/W2108743612","https://openalex.org/W2115346550","https://openalex.org/W2116929481","https://openalex.org/W2130513535","https://openalex.org/W2138887185","https://openalex.org/W2139021664","https://openalex.org/W2142943268","https://openalex.org/W2149707830","https://openalex.org/W2165499430","https://openalex.org/W3120153401"],"related_works":["https://openalex.org/W1982875501","https://openalex.org/W1973991237","https://openalex.org/W7100986040","https://openalex.org/W2018313294","https://openalex.org/W2066582914","https://openalex.org/W2140247458","https://openalex.org/W3134023957","https://openalex.org/W3200878252","https://openalex.org/W2015516488","https://openalex.org/W2740065053"],"abstract_inverted_index":{"Glucocorticoid-induced":[0],"TNF":[1,11,83],"receptor":[2,16,111],"ligand":[3],"(GITRL),":[4],"a":[5,32,66,76,135],"recently":[6],"identified":[7],"member":[8],"of":[9,35,99,129,143],"the":[10,43,60,127,139,146,152],"family,":[12],"binds":[13],"to":[14,70,137,151],"its":[15,110],"GITR":[17],"on":[18],"both":[19],"effector":[20],"and":[21,25,74,114],"regulatory":[22],"T":[23,36],"cells":[24],"generates":[26],"positive":[27],"costimulatory":[28,118],"signals":[29],"implicated":[30],"in":[31,72,104,109,116,123],"wide":[33],"range":[34],"cell":[37],"functions.":[38],"Structural":[39],"analysis":[40],"reveals":[41],"that":[42,125],"human":[44],"GITRL":[45],"(hGITRL)":[46],"ectodomain":[47,102],"self-assembles":[48],"into":[49],"an":[50,105],"atypical":[51],"expanded":[52],"homotrimer":[53],"with":[54,59],"sparse":[55],"monomer-monomer":[56],"interfaces.":[57],"Consistent":[58],"small":[61],"intersubunit":[62],"interfaces,":[63],"hGITRL":[64,101],"exhibits":[65],"relatively":[67],"weak":[68],"tendency":[69],"trimerize":[71],"solution":[73],"displays":[75],"monomer-trimer":[77],"equilibrium":[78,132],"not":[79],"reported":[80],"for":[81,93],"other":[82],"family":[84],"members.":[85],"This":[86],"unique":[87],"assembly":[88],"behavior":[89],"has":[90],"direct":[91],"implications":[92],"hGITRL-GITR":[94,147],"signaling,":[95],"because":[96],"enforced":[97],"trimerization":[98],"soluble":[100],"results":[103],"approximately":[106],"100-fold":[107],"increase":[108],"binding":[112],"affinity":[113,124],"also":[115],"enhanced":[117],"activity.":[119],"The":[120],"apparent":[121],"reduction":[122],"is":[126],"consequence":[128],"this":[130],"dynamic":[131],"may":[133],"represent":[134],"mechanism":[136],"realize":[138],"biologically":[140],"optimal":[141],"level":[142],"signaling":[144],"through":[145],"pathway,":[148],"as":[149],"opposed":[150],"maximal":[153],"achievable":[154],"level.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}