{"id":"https://openalex.org/W2007847006","doi":"https://doi.org/10.1371/journal.pone.0013026","title":"Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim","display_name":"Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim","publication_year":2010,"publication_date":"2010-09-27","ids":{"openalex":"https://openalex.org/W2007847006","doi":"https://doi.org/10.1371/journal.pone.0013026","mag":"2007847006","pmid":"https://pubmed.ncbi.nlm.nih.gov/20885957","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2946397"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0013026","doi":"https://doi.org/10.1371/journal.pone.0013026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0013026","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013026&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013026&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109163820","display_name":"Jieru Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jieru Meng","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America. jmeng@mdanderson.org","Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America. jmeng@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034128046","display_name":"Bingliang Fang","orcid":"https://orcid.org/0000-0001-9225-3010","observed_orcids":["https://orcid.org/0000-0001-9225-3010"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingliang Fang","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037544930","display_name":"Yong Liao","orcid":"https://orcid.org/0000-0001-8379-4720","observed_orcids":["https://orcid.org/0000-0001-8379-4720","https://orcid.org/0009-0001-2447-7124"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Liao","raw_affiliation_strings":["Department of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017227434","display_name":"Christine M. Chresta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christine M. Chresta","raw_affiliation_strings":["Cancer and Infection Research, Astrazeneca, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Infection Research, Astrazeneca, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039299082","display_name":"Paul D. Smith","orcid":"https://orcid.org/0000-0002-2812-5978","observed_orcids":["https://orcid.org/0000-0002-2812-5978"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul D. Smith","raw_affiliation_strings":["Cancer and Infection Research, Astrazeneca, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Infection Research, Astrazeneca, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027152610","display_name":"Jack A. Roth","orcid":"https://orcid.org/0000-0002-8955-1313","observed_orcids":["https://orcid.org/0000-0002-8955-1313"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack A. Roth","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109163820"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.6147,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.81865488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"9","first_page":"e13026","last_page":"e13026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.7590000033378601},{"id":"https://openalex.org/keywords/selumetinib","display_name":"selumetinib","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7940000295639038},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8029999732971191},{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.8980000019073486},{"id":"https://openalex.org/keywords/pmaip1","display_name":"Noxa","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.697253942489624},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6151847243309021},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5690352320671082},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5078349709510803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4994983673095703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48504918813705444},{"id":"https://openalex.org/C2777417711","wikidata":"https://www.wikidata.org/wiki/Q270748","display_name":"Puma","level":3,"score":0.4700689911842346},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46037277579307556},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4602600038051605},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45052793622016907},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4347727298736572},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3203107714653015},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27472424507141113},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2726261019706726},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07264864444732666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05469310283660889}],"mesh":[{"descriptor_ui":"D000071316","descriptor_name":"Forkhead Box Protein O3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072224","descriptor_name":"Bcl-2-Like Protein 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048370","descriptor_name":"MAP Kinase Kinase 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048370","descriptor_name":"MAP Kinase Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048370","descriptor_name":"MAP Kinase Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0013026","doi":"https://doi.org/10.1371/journal.pone.0013026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0013026","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013026&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2946397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2946397","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20885957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20885957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.350.4804","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.350.4804","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/94/38/PLoS_One_2010_Sep_27_5(9)_e13026.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5eae3d309ecf4c5ba2b10f11a559776e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5eae3d309ecf4c5ba2b10f11a559776e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 9, p e13026 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0013026","doi":"https://doi.org/10.1371/journal.pone.0013026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0013026","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013026&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1234894026","display_name":null,"funder_award_id":"CA-092487","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2675416652","display_name":null,"funder_award_id":"16672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4192131250","display_name":null,"funder_award_id":"R01CA-092487","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5746294","display_name":"Targeting Lung Cancer Vulnerabilities","funder_award_id":"P50CA070907","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7119157317","display_name":"Oncolytic adenovector-mediated TRAIL gene therapy for cancers","funder_award_id":"5r01ca092487-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007847006.pdf","grobid_xml":"https://content.openalex.org/works/W2007847006.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1422650632","https://openalex.org/W1625966995","https://openalex.org/W1745634660","https://openalex.org/W1976883744","https://openalex.org/W1984368782","https://openalex.org/W1987359254","https://openalex.org/W1992787379","https://openalex.org/W2004361323","https://openalex.org/W2005909927","https://openalex.org/W2011785467","https://openalex.org/W2024306318","https://openalex.org/W2027798317","https://openalex.org/W2031260839","https://openalex.org/W2045563337","https://openalex.org/W2046623154","https://openalex.org/W2055288483","https://openalex.org/W2062807784","https://openalex.org/W2065678329","https://openalex.org/W2073165102","https://openalex.org/W2079852092","https://openalex.org/W2095736338","https://openalex.org/W2097767970","https://openalex.org/W2106917466","https://openalex.org/W2108958930","https://openalex.org/W2116508133","https://openalex.org/W2116787167","https://openalex.org/W2137035181","https://openalex.org/W2143838754","https://openalex.org/W2150456795","https://openalex.org/W2151791302","https://openalex.org/W2152636515","https://openalex.org/W2156320420","https://openalex.org/W2157016650","https://openalex.org/W2162147795","https://openalex.org/W2166525118","https://openalex.org/W2328267773","https://openalex.org/W2330709458","https://openalex.org/W4250625253"],"related_works":["https://openalex.org/W2326589649","https://openalex.org/W2143838754","https://openalex.org/W2035175520","https://openalex.org/W2114621192","https://openalex.org/W1541498995","https://openalex.org/W7096856623","https://openalex.org/W2116796524","https://openalex.org/W2138702921","https://openalex.org/W2048922769","https://openalex.org/W2769285909"],"abstract_inverted_index":{"AZD6244":[0,34,62,67,120,146],"(ARRY-142886)":[1],"is":[2,27,210],"an":[3,195],"inhibitor":[4],"of":[5,24,33,46,49,72,79,108,128,158,172,217,230],"MEK1/2":[6],"and":[7,75,81,84,116,131,178,181,205,215],"can":[8],"inhibit":[9],"cell":[10,53,86,92,105,164],"proliferation":[11],"or":[12,59],"induce":[13],"apoptosis":[14,26,36,118,200],"in":[15,37,88,103,135,139,186,198,201,212,227],"a":[16,69,76],"cell-type":[17],"dependent":[18],"manner.":[19],"The":[20],"precise":[21],"molecular":[22,44],"mechanism":[23],"AZD6244-induced":[25,163,183,199],"not":[28],"clear.":[29],"To":[30],"investigate":[31],"mechanisms":[32],"induced":[35,85,147],"human":[38,50],"lung":[39,51,90,202,218],"cancer,":[40],"we":[41,168],"determined":[42],"the":[43,114,143,156,207,228],"changes":[45],"two":[47],"subgroups":[48],"cancer":[52,91,203,219],"lines":[54],"that":[55,66,126,170,192,206],"are":[56],"either":[57],"sensitive":[58,89,144,187],"resistant":[60],"to":[61,221,232,235],"treatment.":[63],"We":[64,123],"found":[65,125,169],"elicited":[68],"large":[70],"increase":[71,78],"Bim":[73,109,153,184,193,213],"proteins":[74,102],"smaller":[77],"PUMA":[80],"NOXA":[82],"proteins,":[83],"death":[87],"lines,":[93],"but":[94],"had":[95],"no":[96],"effect":[97],"on":[98],"other":[99],"Bcl-2":[100],"related":[101],"those":[104],"lines.":[106],"Knockdown":[107],"by":[110,160],"siRNA":[111,161],"greatly":[112],"increased":[113],"IC(50)":[115],"reduced":[117],"for":[119,152],"treated":[121],"cells.":[122,141,188],"also":[124],"levels":[127],"endogenous":[129],"p-Thr32-FOXO3a":[130,177],"p-Ser253-FOXO3a":[132,179],"were":[133],"lower":[134],"AZD6244-sensitive":[136],"cells":[137,204,220],"than":[138],"AZD6244-resistant":[140],"In":[142,166],"cells,":[145],"FOXO3a":[148,159],"nuclear":[149],"translocation":[150],"required":[151],"activation.":[154],"Moreover,":[155],"silencing":[157],"abrogated":[162],"apoptosis.":[165],"addition,":[167],"transfection":[171],"constitutively":[173],"active":[174],"AKT":[175],"up-regulated":[176],"expression":[180,185],"inhibited":[182],"These":[189,223],"results":[190,224],"show":[191],"plays":[194],"important":[196],"role":[197],"PI3K/AKT/FOXO3a":[208],"pathway":[209],"involved":[211],"regulation":[214],"susceptibility":[216],"AZD6244.":[222],"have":[225],"implications":[226],"development":[229],"strategies":[231],"overcome":[233],"resistance":[234],"MEK":[236],"inhibitors.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
