{"id":"https://openalex.org/W2007830428","doi":"https://doi.org/10.1021/ja9942742","title":"A Highly Stable, Six-Hydrogen-Bonded Molecular Duplex","display_name":"A Highly Stable, Six-Hydrogen-Bonded Molecular Duplex","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2007830428","doi":"https://doi.org/10.1021/ja9942742","mag":"2007830428"},"language":"en","primary_location":{"id":"doi:10.1021/ja9942742","doi":"https://doi.org/10.1021/ja9942742","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja9942742","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076184584","display_name":"Huaqiang Zeng","orcid":"https://orcid.org/0000-0002-8246-2000","observed_orcids":["https://orcid.org/0000-0002-8246-2000","https://orcid.org/0009-0007-1496-5099"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaqiang Zeng","raw_affiliation_strings":["Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rebecca S. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca S. Miller","raw_affiliation_strings":["Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072523681","display_name":"Robert A. II Flowers","orcid":"https://orcid.org/0000-0003-2295-1336","observed_orcids":["https://orcid.org/0000-0003-2295-1336"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Flowers","raw_affiliation_strings":["Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088103200","display_name":"Bing Gong","orcid":"https://orcid.org/0000-0002-4155-9965","observed_orcids":["https://orcid.org/0000-0002-4155-9965"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Gong","raw_affiliation_strings":["Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, The University of Toledo, Toledo, Ohio 43606","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.9637,"has_fulltext":false,"cited_by_count":205,"citation_normalized_percentile":{"value":0.98213519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"122","issue":"11","first_page":"2635","last_page":"2644"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.11029999703168869,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligoamides","display_name":"oligoamides","score":0.8330000042915344},{"id":"https://openalex.org/keywords/supramolecular-recognition","display_name":"supramolecular recognition","score":0.6769999861717224},{"id":"https://openalex.org/keywords/duplex-stability","display_name":"duplex stability","score":0.4830000102519989},{"id":"https://openalex.org/keywords/positive-cooperativity","display_name":"positive cooperativity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/intramolecular-hydrogen-bonding","display_name":"intramolecular hydrogen bonding","score":0.8840000033378601},{"id":"https://openalex.org/keywords/van-der-waals-forces","display_name":"van der Waals interactions","score":0.8849999904632568},{"id":"https://openalex.org/keywords/complementary-strands","display_name":"complementary strands","score":0.375},{"id":"https://openalex.org/keywords/supramolecular-chemistry","display_name":"supramolecular chemistry","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9121460318565369},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.7988542318344116},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7987600564956665},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.7266594171524048},{"id":"https://openalex.org/C126061179","wikidata":"https://www.wikidata.org/wiki/Q189627","display_name":"van der Waals force","level":3,"score":0.705201268196106},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.6899522542953491},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.6274080276489258},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.6272082924842834},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4559198021888733},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.4529432952404022},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4526623487472534},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.4457401633262634},{"id":"https://openalex.org/C119473381","wikidata":"https://www.wikidata.org/wiki/Q49298","display_name":"Force spectroscopy","level":3,"score":0.42067861557006836},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.3924846351146698},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.23785433173179626},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.17814484238624573},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1455169916152954},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.08799496293067932},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.074984610080719},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/ja9942742","doi":"https://doi.org/10.1021/ja9942742","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja9942742","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1487219881","https://openalex.org/W1490205786","https://openalex.org/W1584476217","https://openalex.org/W1975263049","https://openalex.org/W1976910469","https://openalex.org/W1976930130","https://openalex.org/W1998920258","https://openalex.org/W2005483469","https://openalex.org/W2017119618","https://openalex.org/W2017488022","https://openalex.org/W2020162594","https://openalex.org/W2020357919","https://openalex.org/W2035350783","https://openalex.org/W2037730843","https://openalex.org/W2039985930","https://openalex.org/W2040404466","https://openalex.org/W2058090403","https://openalex.org/W2075206362","https://openalex.org/W2098217369","https://openalex.org/W2098850811","https://openalex.org/W2108655746","https://openalex.org/W2122248295","https://openalex.org/W2122320069","https://openalex.org/W2153637794","https://openalex.org/W2167330395","https://openalex.org/W4249649290"],"related_works":["https://openalex.org/W2762132024","https://openalex.org/W2091804166","https://openalex.org/W1976483388","https://openalex.org/W1987902397","https://openalex.org/W2324259686","https://openalex.org/W2951248780","https://openalex.org/W29804617","https://openalex.org/W2093042977","https://openalex.org/W2091469091","https://openalex.org/W2015477064"],"abstract_inverted_index":{"This":[0,117],"paper":[1],"describes":[2],"the":[3,26,80,83,87,98,107,110],"design,":[4],"synthesis,":[5],"and":[6,23,31,67,76,82,101,106,131],"characterization":[7],"of":[8,86,109],"a":[9,43,121],"hydrogen-bonded":[10],"molecular":[11,20,55],"duplex":[12,56],"(":[13,41,57],"3":[14,22,58],"\u00b7":[15,59],"4":[16,60],").":[17],"Two":[18],"oligoamide":[19],"strands,":[21],"4,":[24],"with":[25,128],"complementary":[27],"hydrogen-bonding":[28,100],"sequences":[29],"ADAADA":[30],"DADDAD,":[32],"respectively,":[33],"were":[34],"found":[35],"to":[36,124],"form":[37],"an":[38],"extremely":[39],"stable":[40],"K":[42],"=":[44],"(1.3":[45],"\u00b1":[46],"0.7)":[47],"\u00d7":[48],"10":[49],"9":[50],"M":[51],"-":[52],"1":[53,69],")":[54,61],"in":[62],"chloroform.":[63],"Evidence":[64],"from":[65],"1D":[66],"2D":[68],"H":[70],"NMR":[71],"spectroscopy,":[72],"isothermal":[73],"titration":[74],"calorimetry,":[75],"thin-layer":[77],"chromatography":[78],"confirmed":[79],"formation":[81],"high":[84],"stability":[85,91],"duplex.":[88],"The":[89],"exceptional":[90],"is":[92],"explained":[93],"by":[94,113],"positive":[95],"cooperativity":[96],"among":[97],"numerous":[99],"van":[102],"der":[103],"Waals":[104],"interactions":[105],"preorganization":[108],"individual":[111],"strands":[112],"intramolecular":[114],"hydrogen":[115],"bonds.":[116],"design":[118],"has":[119],"opened":[120],"new":[122],"avenue":[123],"supramolecular":[125],"recognition":[126],"units":[127],"programmable":[129],"specificities":[130],"stabilities.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}