{"id":"https://openalex.org/W2007809829","doi":"https://doi.org/10.1002/glia.22449","title":"Dopamine D3 receptor activation promotes neural stem/progenitor cell proliferation through AKT and ERK1/2 pathways and expands type\u2010B and \u2010C cells in adult subventricular zone","display_name":"Dopamine D3 receptor activation promotes neural stem/progenitor cell proliferation through AKT and ERK1/2 pathways and expands type\u2010B and \u2010C cells in adult subventricular zone","publication_year":2013,"publication_date":"2013-01-16","ids":{"openalex":"https://openalex.org/W2007809829","doi":"https://doi.org/10.1002/glia.22449","mag":"2007809829","pmid":"https://pubmed.ncbi.nlm.nih.gov/23322492"},"language":"en","primary_location":{"id":"doi:10.1002/glia.22449","doi":"https://doi.org/10.1002/glia.22449","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.22449","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012275411","display_name":"Chu Lan Lao","orcid":"https://orcid.org/0000-0001-9856-9884","observed_orcids":["https://orcid.org/0000-0001-9856-9884"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chu Lan Lao","raw_affiliation_strings":["Department of Physiology and Pharmacology, Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110907233","display_name":"Chin\u2010Song Lu","orcid":"https://orcid.org/0009-0003-2375-1499","observed_orcids":["https://orcid.org/0009-0003-2375-1499"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chin\u2010Song Lu","raw_affiliation_strings":["Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan","Neuroscience Research Center, Chang Gung Memorial Hospital, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Neuroscience Research Center, Chang Gung Memorial Hospital, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027466098","display_name":"Jin\u2010Chung Chen","orcid":"https://orcid.org/0000-0003-2996-5781","observed_orcids":["https://orcid.org/0000-0003-2996-5781"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jin\u2010Chung Chen","raw_affiliation_strings":["Department of Physiology and Pharmacology, Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan","Healthy Ageing Research Center, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Healthy Ageing Research Center, Chang Gung University, Tao-Yuan, Kwei-Shan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027466098"],"corresponding_institution_ids":["https://openalex.org/I173093425"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.35,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.87263394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"61","issue":"4","first_page":"475","last_page":"489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subventricular-zone","display_name":"subventricular zone","score":0.8859999775886536},{"id":"https://openalex.org/keywords/neural-stem-progenitor-cells","display_name":"neural stem/progenitor cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7870000004768372},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/7-oh-dpat","display_name":"7-OH-DPAT","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8119999766349792},{"id":"https://openalex.org/keywords/neuroblasts","display_name":"neuroblasts","score":0.6489999890327454},{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/d3-receptor-agonists","display_name":"D3 receptor agonists","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2777542384","wikidata":"https://www.wikidata.org/wiki/Q937403","display_name":"Subventricular zone","level":4,"score":0.8658225536346436},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8148667812347412},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7382267713546753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7327474355697632},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.5693256855010986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.545426607131958},{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.5321877002716064},{"id":"https://openalex.org/C2781461022","wikidata":"https://www.wikidata.org/wiki/Q14912973","display_name":"Doublecortin","level":4,"score":0.5125203132629395},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4461266100406647},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4143759608268738},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.33347994089126587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2859548330307007},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.17438942193984985},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.11944553256034851},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.10965710878372192},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07112041115760803},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000089662","descriptor_name":"Doublecortin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013764","descriptor_name":"Tetrahydronaphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020547","descriptor_name":"Lateral Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020547","descriptor_name":"Lateral Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020547","descriptor_name":"Lateral Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050637","descriptor_name":"Receptors, Dopamine D3","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050637","descriptor_name":"Receptors, Dopamine D3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050637","descriptor_name":"Receptors, Dopamine D3","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/glia.22449","doi":"https://doi.org/10.1002/glia.22449","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.22449","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:23322492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23322492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W51412267","https://openalex.org/W1487852103","https://openalex.org/W1536502239","https://openalex.org/W1554815317","https://openalex.org/W1574542597","https://openalex.org/W1606391227","https://openalex.org/W1729507488","https://openalex.org/W1812632553","https://openalex.org/W1925492557","https://openalex.org/W1964417952","https://openalex.org/W1966535247","https://openalex.org/W1966812624","https://openalex.org/W1970828908","https://openalex.org/W1972893985","https://openalex.org/W1975689060","https://openalex.org/W1977394930","https://openalex.org/W1979867194","https://openalex.org/W1987169758","https://openalex.org/W1999625021","https://openalex.org/W2000246164","https://openalex.org/W2000253969","https://openalex.org/W2007746109","https://openalex.org/W2024612251","https://openalex.org/W2025042523","https://openalex.org/W2031407988","https://openalex.org/W2035250926","https://openalex.org/W2044416702","https://openalex.org/W2046139547","https://openalex.org/W2048937194","https://openalex.org/W2050179078","https://openalex.org/W2055561480","https://openalex.org/W2064759994","https://openalex.org/W2071656982","https://openalex.org/W2073710861","https://openalex.org/W2084652820","https://openalex.org/W2086371555","https://openalex.org/W2086718095","https://openalex.org/W2091535724","https://openalex.org/W2106112825","https://openalex.org/W2107561896","https://openalex.org/W2109542855","https://openalex.org/W2118825726","https://openalex.org/W2124446289","https://openalex.org/W2127312785","https://openalex.org/W2132349207","https://openalex.org/W2132367339","https://openalex.org/W2135611720","https://openalex.org/W2138684224","https://openalex.org/W2145430337","https://openalex.org/W2150700826","https://openalex.org/W2156386980","https://openalex.org/W2160280025","https://openalex.org/W2164142213","https://openalex.org/W2165867905","https://openalex.org/W2168690349","https://openalex.org/W2230711217","https://openalex.org/W2414699299"],"related_works":["https://openalex.org/W1574542597","https://openalex.org/W2106112825","https://openalex.org/W1729507488","https://openalex.org/W2046139547","https://openalex.org/W1992509051","https://openalex.org/W4214598071","https://openalex.org/W1981545710","https://openalex.org/W2050179078","https://openalex.org/W2044416702","https://openalex.org/W2095486385"],"abstract_inverted_index":{"The":[0],"neurotransmitter":[1],"dopamine":[2],"acts":[3],"on":[4],"the":[5,29,63,129,146,205,235,255,263],"subventricular":[6],"zone":[7],"(SVZ)":[8],"to":[9,224],"regulate":[10],"both":[11],"prenatal":[12],"and":[13,37,94,97,112,167,188,199,204,250,253,259],"postnatal":[14],"neurogenesis,":[15],"in":[16,56,71,75,103,122,128,138,159,218,234,262],"particular":[17],"through":[18,248],"D(3)":[19,33,44,64,83,88,139,151,175,193,219,228,242],"receptor":[20,170],"(D(3)":[21],"R)":[22],"subtype.":[23],"In":[24],"this":[25,133],"study,":[26],"we":[27,144,190,239],"explored":[28],"cellular":[30,110],"mechanism(s)":[31],"underlying":[32],"R-mediated":[34],"cell":[35,53,69,126,147,154,202,214],"proliferation":[36,55,70,247],"tested":[38],"if":[39],"systemic":[40],"delivery":[41],"of":[42,100,150,257],"a":[43,72,106],"R":[45,65,84,89,140,152,176,194,220,229,243],"agonist":[46],"would":[47],"induce":[48],"SVZ":[49,77],"multipotent":[50],"neural":[51],"stem/precursor":[52],"(NSC/NPC)":[54],"vivo.":[57],"We":[58,156],"found":[59,157],"that":[60,158,192,227,241],"treatment":[61,117],"with":[62,118],"agonist,":[66],"7-OH-DPAT,":[67],"enhances":[68,95],"dose-dependent":[73],"manner":[74],"cultured":[76],"neurospheres":[78],"from":[79],"wild-type,":[80],"but":[81,132,178],"not":[82,136],"knock-out":[85],"mice.":[86,142],"Furthermore,":[87],"activation":[90,195,244],"also":[91],"stimulates":[92],"S-phase":[93],"mRNA":[96],"protein":[98],"levels":[99],"cyclin":[101],"D1":[102],"wild-type":[104],"neurospheres,":[105],"process":[107],"which":[108],"requires":[109],"Akt":[111,249],"ERK1/2":[113,251],"signaling.":[114],"Moreover,":[115],"chronic":[116],"low":[119],"dose":[120],"7-OH-DAPT":[121],"vivo":[123],"increases":[124,196,254],"BrdU(+)":[125,212],"numbers":[127,215,256],"adult":[130,160,236,264],"SVZ,":[131,161],"effect":[134],"was":[135],"seen":[137],"KO":[141,221],"Additionally,":[143],"probed":[145],"type":[148],"specificity":[149],"agonist-mediated":[153],"proliferation.":[155],"GFAP(+)":[162,165,197],"astrocytes,":[163],"type-B":[164,198,258],"/nestin(+)":[166],"type-C":[168,201],"EGF":[169],"(EGFR(+)":[171],")/nestin(+)":[172],"cells":[173],"express":[174],"mRNA,":[177],"type-A":[179,209],"Doublecortin":[180],"(Dcx)(+)":[181],"neuroblasts":[182],"do":[183],"not.":[184],"Using":[185],"flow":[186],"cytometry":[187],"immunofluorescence,":[189],"demonstrated":[191],"EGFR(+)":[200],"numbers,":[203],"newly":[206],"divided":[207],"Dcx(+)":[208],"cells.":[210],"However,":[211],"/Dcx(+)":[213],"were":[216],"decreased":[217],"mice":[222],"compared":[223],"wildtype,":[225],"suggesting":[226],"maintains":[230],"constitutive":[231],"NSC/NPCs":[232,261],"population":[233],"SVZ.":[237,265],"Overall,":[238],"demonstrate":[240],"induces":[245],"NSC/NPC":[246],"signaling":[252],"-C":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}