{"id":"https://openalex.org/W2007807635","doi":"https://doi.org/10.1002/14651858.cd005496.pub4","title":"Probiotics for prevention of necrotizing enterocolitis in preterm infants","display_name":"Probiotics for prevention of necrotizing enterocolitis in preterm infants","publication_year":2014,"publication_date":"2014-04-10","ids":{"openalex":"https://openalex.org/W2007807635","doi":"https://doi.org/10.1002/14651858.cd005496.pub4","mag":"2007807635","pmid":"https://pubmed.ncbi.nlm.nih.gov/24723255"},"language":"en","primary_location":{"id":"doi:10.1002/14651858.cd005496.pub4","doi":"https://doi.org/10.1002/14651858.cd005496.pub4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd005496.pub4","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110094337","display_name":"Khalid M. AlFaleh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]},{"id":"https://openalex.org/I4210138988","display_name":"King Khalid University Hospital","ror":"https://ror.org/046gga527","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210138988"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Khalid AlFaleh","raw_affiliation_strings":["King Saud University; Department of Pediatrics (Division of Neonatology); King Khalid University Hospital and College of Medicine Department of Pediatrics (39), P.O. Box 2925 Riyadh Saudi Arabia 11461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud University; Department of Pediatrics (Division of Neonatology); King Khalid University Hospital and College of Medicine Department of Pediatrics (39), P.O. Box 2925 Riyadh Saudi Arabia 11461","institution_ids":["https://openalex.org/I28022161","https://openalex.org/I4210138988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066794382","display_name":"Jasim Anabrees","orcid":"https://orcid.org/0000-0001-9871-8528","observed_orcids":["https://orcid.org/0000-0001-9871-8528"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jasim Anabrees","raw_affiliation_strings":["Sulaiman Al Habib Medical Group; Neonatal Care; Arrayan Hospital P.O. Box 272069 Riyadh Saudi Arabia 11352"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sulaiman Al Habib Medical Group; Neonatal Care; Arrayan Hospital P.O. Box 272069 Riyadh Saudi Arabia 11352","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":null,"fwci":89.6234,"has_fulltext":false,"cited_by_count":974,"citation_normalized_percentile":{"value":0.99983944,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"584","last_page":"671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.875},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.984000027179718},{"id":"https://openalex.org/keywords/nosocomial-sepsis","display_name":"nosocomial sepsis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nec-prevention","display_name":"NEC prevention","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nec-mortality","display_name":"NEC mortality","score":0.675000011920929},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.9551441669464111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.695380449295044},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4835795760154724},{"id":"https://openalex.org/C2776258884","wikidata":"https://www.wikidata.org/wiki/Q3055368","display_name":"Enterocolitis","level":2,"score":0.46883314847946167},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3637857437133789},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.28102588653564453}],"mesh":[{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019102","descriptor_name":"Infant, Very Low Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019102","descriptor_name":"Infant, Very Low Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019102","descriptor_name":"Infant, Very Low Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019102","descriptor_name":"Infant, Very Low Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/14651858.cd005496.pub4","doi":"https://doi.org/10.1002/14651858.cd005496.pub4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd005496.pub4","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},{"id":"pmid:24723255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24723255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cochrane database of systematic reviews","raw_type":"Journal Article"},{"id":"pmid:25236307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25236307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based child health : a Cochrane review journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W167729265","https://openalex.org/W1537972189","https://openalex.org/W1727692719","https://openalex.org/W1963588808","https://openalex.org/W1965180855","https://openalex.org/W1967635563","https://openalex.org/W1968086572","https://openalex.org/W1968088790","https://openalex.org/W1975434115","https://openalex.org/W1975552661","https://openalex.org/W1980210906","https://openalex.org/W1986936861","https://openalex.org/W1989385297","https://openalex.org/W1991753673","https://openalex.org/W1993141690","https://openalex.org/W1996336860","https://openalex.org/W2000396235","https://openalex.org/W2010220405","https://openalex.org/W2017046795","https://openalex.org/W2019549525","https://openalex.org/W2020186144","https://openalex.org/W2022632044","https://openalex.org/W2025153081","https://openalex.org/W2026794825","https://openalex.org/W2048246803","https://openalex.org/W2053478547","https://openalex.org/W2054501914","https://openalex.org/W2056643196","https://openalex.org/W2057311454","https://openalex.org/W2060776197","https://openalex.org/W2061695424","https://openalex.org/W2062611710","https://openalex.org/W2063023372","https://openalex.org/W2064188086","https://openalex.org/W2068140733","https://openalex.org/W2070985583","https://openalex.org/W2076452367","https://openalex.org/W2077986496","https://openalex.org/W2079576804","https://openalex.org/W2083049393","https://openalex.org/W2083320211","https://openalex.org/W2085319013","https://openalex.org/W2097900300","https://openalex.org/W2098557460","https://openalex.org/W2100119754","https://openalex.org/W2105725053","https://openalex.org/W2111162427","https://openalex.org/W2114811866","https://openalex.org/W2119054244","https://openalex.org/W2120528311","https://openalex.org/W2124087884","https://openalex.org/W2124294323","https://openalex.org/W2129728250","https://openalex.org/W2141149342","https://openalex.org/W2148719195","https://openalex.org/W2155248348","https://openalex.org/W2157716742","https://openalex.org/W2168000169","https://openalex.org/W2169662494","https://openalex.org/W2216607261","https://openalex.org/W2266296570","https://openalex.org/W2301034803","https://openalex.org/W2313919103","https://openalex.org/W2321143959","https://openalex.org/W2385243819","https://openalex.org/W2401900109","https://openalex.org/W2443625672","https://openalex.org/W2498460850","https://openalex.org/W4244407439","https://openalex.org/W4300425742"],"related_works":["https://openalex.org/W3015717938","https://openalex.org/W2300046951","https://openalex.org/W4322773015","https://openalex.org/W2082136782","https://openalex.org/W2325845343","https://openalex.org/W1509450179","https://openalex.org/W2054756716","https://openalex.org/W2077704628","https://openalex.org/W2139847602","https://openalex.org/W2940540567"],"abstract_inverted_index":{"BACKGROUND:":[0],"Necrotizing":[1,414],"enterocolitis":[2,410,415],"(NEC)":[3,416],"and":[4,12,30,51,60,119,174,192,206,210,233,250,289,362,395,446,482,502],"nosocomial":[5,311],"sepsis":[6,312],"are":[7,386],"associated":[8,53],"with":[9,224,332,346,497],"increased":[10],"morbidity":[11],"mortality":[13,290,365],"in":[14,48,72,82,112,240,344,366,379,411,428,484,506],"preterm":[15,83,143,367,412],"infants.":[16,84,368],"Through":[17],"prevention":[18,74,407],"of":[19,27,35,62,75,93,108,121,124,168,188,203,238,247,256,266,307,310,357,372,397,408,425,433,438,469,475,480],"bacterial":[20,447],"migration":[21],"across":[22],"the":[23,32,36,52,58,73,104,125,200,204,241,248,264,333,390,423,429,436,473,478,500,507],"mucosa,":[24],"competitive":[25],"exclusion":[26],"pathogenic":[28],"bacteria,":[29],"enhancing":[31],"immune":[33],"responses":[34],"host,":[37],"prophylactic":[38,63],"enteral":[39,64,166,259],"probiotics":[40,65,260,335,358,476],"(live":[41],"microbial":[42,171],"supplements)":[43],"may":[44],"play":[45,449],"a":[46,254,377,418,450],"role":[47],"reducing":[49],"NEC":[50,77,239,268,361,439,481],"morbidity.":[54],"OBJECTIVES:":[55],"To":[56],"compare":[57],"efficacy":[59],"safety":[61],"administration":[66,167],"versus":[67],"placebo":[68],"or":[69,78,80,137,150,156,271,343,459],"no":[70,305,329],"treatment":[71],"severe":[76,267,360],"sepsis,":[79],"both,":[81,157],"SEARCH":[85],"METHODS:":[86],"For":[87],"this":[88],"update,":[89],"searches":[90],"were":[91,158,161,196,217,221,348],"made":[92],"MEDLINE":[94],"(1966":[95],"to":[96,101,131,198,226,283,297,319,350,382,388,399,464,499],"October":[97,102],"2013),":[98,103],"EMBASE":[99],"(1980":[100],"Cochrane":[105,114,190],"Central":[106],"Register":[107],"Controlled":[109],"Trials":[110,160],"(CENTRAL)":[111],"The":[113,189,325],"Library":[115],"(2013,":[116],"Issue":[117],"10),":[118],"abstracts":[120],"annual":[122],"meetings":[123],"Society":[126],"for":[127,207,406],"Pediatric":[128],"Research":[129],"(1995":[130],"2013).":[132],"SELECTION":[133],"CRITERIA:":[134],"Only":[135],"randomized":[136],"quasi-randomized":[138],"controlled":[139],"trials":[140,205,216,220,327],"that":[141,421,472],"enrolled":[142],"infants":[144,413,427,486,511],"<":[145,151],"37":[146],"weeks":[147,432],"gestational":[148,234],"age":[149],"2500":[152],"g":[153],"birth":[154,231],"weight,":[155],"considered.":[159],"included":[162,326],"if":[163],"they":[164],"involved":[165],"any":[169],"live":[170],"supplement":[172],"(probiotics)":[173],"measured":[175],"at":[176,509,517],"least":[177],"one":[178],"prespecified":[179],"clinical":[180],"outcome.":[181],"DATA":[182],"COLLECTION":[183],"AND":[184],"ANALYSIS:":[185],"Standard":[186],"methods":[187],"Collaboration":[191],"its":[193],"Neonatal":[194],"Group":[195],"used":[197,463],"assess":[199,389],"methodologic":[201],"quality":[202],"data":[208,496],"collection":[209],"analysis.":[211],"MAIN":[212],"RESULTS:":[213],"Twenty-four":[214],"eligible":[215],"included.":[218],"Included":[219],"highly":[222],"variable":[223],"regard":[225,498],"enrolment":[227],"criteria":[228],"(that":[229],"is":[230,417,440,494],"weight":[232],"age),":[235],"baseline":[236],"risk":[237,275,510],"control":[242],"groups,":[243],"timing,":[244,394],"dose,":[245],"formulation":[246],"probiotics,":[249],"feeding":[251,445],"regimens.":[252],"In":[253],"meta-analysis":[255],"trial":[257],"data,":[258],"supplementation":[261,356],"significantly":[262],"reduced":[263],"incidence":[265],"(stage":[269],"II":[270],"more)":[272],"(typical":[273,291,313],"relative":[274],"(RR)":[276],"0.43,":[277],"95%":[278,294,316],"confidence":[279],"interval":[280],"(CI)":[281],"0.33":[282],"0.56;":[284],"20":[285],"studies,":[286,300,322],"5529":[287],"infants)":[288],"RR":[292,314],"0.65,":[293],"CI":[295,317],"0.52":[296],"0.81;":[298],"17":[299],"5112":[301],"infants).":[302,324],"There":[303,493],"was":[304],"evidence":[306,374],"significant":[308],"reduction":[309],"0.91,":[315],"0.80":[318],"1.03;":[320],"19":[321],"5338":[323],"reported":[328],"systemic":[330],"infection":[331],"supplemental":[334],"organism.":[336],"Probiotics":[337,405,452],"preparations":[338],"containing":[339,455],"either":[340],"lactobacillus":[341],"alone":[342],"combination":[345],"bifidobacterium":[347],"found":[349,471],"be":[351,400],"effective.":[352],"AUTHORS'":[353],"CONCLUSIONS:":[354],"Enteral":[355],"prevents":[359],"all":[363],"cause":[364,437],"Our":[369,467],"updated":[370],"review":[371,468],"available":[373],"strongly":[375],"supports":[376],"change":[378],"practice.":[380],"Head":[381],"head":[383],"comparative":[384],"studies":[385,470],"required":[387],"most":[391,508],"effective":[392],"preparations,":[393],"length":[396],"therapy":[398],"utilized.":[401],"PLAIN":[402],"LANGUAGE":[403],"SUMMARY:":[404],"necrotizing":[409],"serious":[419],"disease":[420],"affects":[422],"bowel":[424],"premature":[426,485],"first":[430],"few":[431],"life.":[434],"Although":[435],"not":[441],"entirely":[442],"known,":[443],"milk":[444],"growth":[448],"role.":[451],"(dietary":[453],"supplements":[454],"potentially":[456],"beneficial":[457],"bacteria":[458],"yeast)":[460],"have":[461],"been":[462],"prevent":[465],"NEC.":[466],"use":[474],"reduces":[477],"occurrence":[479],"death":[483],"born":[487],"weighing":[488,512],"less":[489,513],"than":[490,514],"1500":[491],"grams.":[492],"insufficient":[495],"benefits":[501],"potential":[503],"adverse":[504],"effects":[505],"1000":[515],"grams":[516],"birth.":[518]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":82},{"year":2019,"cited_by_count":65},{"year":2018,"cited_by_count":80},{"year":2017,"cited_by_count":88},{"year":2016,"cited_by_count":91},{"year":2015,"cited_by_count":89},{"year":2014,"cited_by_count":74},{"year":2013,"cited_by_count":64},{"year":2012,"cited_by_count":41}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}