{"id":"https://openalex.org/W2007805771","doi":"https://doi.org/10.3109/08923973.2010.482137","title":"p38-Targeted inhibition of interleukin-12 expression by ethanol extract fromCordyceps bassianain lipopolysaccharide-activated macrophages","display_name":"p38-Targeted inhibition of interleukin-12 expression by ethanol extract fromCordyceps bassianain lipopolysaccharide-activated macrophages","publication_year":2010,"publication_date":"2010-05-17","ids":{"openalex":"https://openalex.org/W2007805771","doi":"https://doi.org/10.3109/08923973.2010.482137","mag":"2007805771","pmid":"https://pubmed.ncbi.nlm.nih.gov/20476843"},"language":"en","primary_location":{"id":"doi:10.3109/08923973.2010.482137","doi":"https://doi.org/10.3109/08923973.2010.482137","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923973.2010.482137","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090746708","display_name":"Se Eun Byeon","orcid":"https://orcid.org/0000-0002-1592-2660","observed_orcids":["https://orcid.org/0000-0002-1592-2660"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Se Eun Byeon","raw_affiliation_strings":["School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea","School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072215398","display_name":"Jaehwi Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaehwi Lee","raw_affiliation_strings":["College of Pharmacy, Chung-Ang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chung-Ang University, Seoul, Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063653461","display_name":"Byong Chul Yoo","orcid":"https://orcid.org/0000-0001-7937-0167","observed_orcids":["https://orcid.org/0000-0001-7937-0167","https://orcid.org/0000-0001-9726-9492"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]},{"id":"https://openalex.org/I4405261544","display_name":"National Cancer Center Hospital","ror":"https://ror.org/05fgmqm64","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052","https://openalex.org/I4405261544"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byong Chul Yoo","raw_affiliation_strings":["Research Institute and Hospital, National Cancer Center, Goyang, Korea","Research Institute & Hospital, National Cancer Center, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute and Hospital, National Cancer Center, Goyang, Korea","institution_ids":["https://openalex.org/I4210120052","https://openalex.org/I4405261544"]},{"raw_affiliation_string":"Research Institute & Hospital, National Cancer Center, Goyang, Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111922388","display_name":"Gi Ho Sung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gi Ho Sung","raw_affiliation_strings":["Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031317974","display_name":"Tae\u2010Woong Kim","orcid":"https://orcid.org/0000-0002-1793-2483","observed_orcids":["https://orcid.org/0000-0002-1793-2483"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Woong Kim","raw_affiliation_strings":["Department of Biochemistry, Kangwon National University, Chuncheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kangwon National University, Chuncheon, Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011359721","display_name":"Hyoung Jin Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyoung Jin Park","raw_affiliation_strings":["Department of Physiology, College of Medicine, Hallym University, Chuncheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, Hallym University, Chuncheon, Korea","institution_ids":["https://openalex.org/I146824383"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001534001","display_name":"Jae Youl Cho","orcid":"https://orcid.org/0000-0001-8141-9927","observed_orcids":["https://orcid.org/0000-0001-8141-9927"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Youl Cho","raw_affiliation_strings":["Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5001534001"],"corresponding_institution_ids":["https://openalex.org/I848706"],"apc_list":null,"apc_paid":null,"fwci":1.0939,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.75681106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"33","issue":"1","first_page":"90","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.9010000228881836},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9520000219345093},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9340000152587891},{"id":"https://openalex.org/keywords/lps-stimulated-macrophages","display_name":"LPS-stimulated macrophages","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8960000276565552},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.7519999742507935},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.8119999766349792},{"id":"https://openalex.org/keywords/sb203580","display_name":"SB203580","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2779085617","wikidata":"https://www.wikidata.org/wiki/Q312238","display_name":"Cordyceps","level":2,"score":0.6768251657485962},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5993676781654358},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5904942154884338},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.44842177629470825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.423510879278183},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41939157247543335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.416303426027298},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3839981257915497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25566673278808594},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23642948269844055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2349153459072113},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.2034010887145996},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1883859634399414},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.06845906376838684}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032661","descriptor_name":"Cordyceps","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08923973.2010.482137","doi":"https://doi.org/10.3109/08923973.2010.482137","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923973.2010.482137","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},{"id":"pmid:20476843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20476843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and immunotoxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1497714878","https://openalex.org/W1898117805","https://openalex.org/W1984616248","https://openalex.org/W1989038593","https://openalex.org/W2030690986","https://openalex.org/W2033991414","https://openalex.org/W2034478920","https://openalex.org/W2042112143","https://openalex.org/W2050996284","https://openalex.org/W2063050287","https://openalex.org/W2077718608","https://openalex.org/W2083639964","https://openalex.org/W2086445082","https://openalex.org/W2107956834","https://openalex.org/W2110940443","https://openalex.org/W2138861348","https://openalex.org/W2150132986","https://openalex.org/W2166616596","https://openalex.org/W2166781237","https://openalex.org/W2171968926","https://openalex.org/W2407740578"],"related_works":["https://openalex.org/W2417540061","https://openalex.org/W2770664560","https://openalex.org/W2746506687","https://openalex.org/W1548538923","https://openalex.org/W2124339110","https://openalex.org/W7100663873","https://openalex.org/W3176457194","https://openalex.org/W3126840400","https://openalex.org/W2782907939","https://openalex.org/W2106702058"],"abstract_inverted_index":{"Cordyceps":[0,40,48,89],"species":[1],"have":[2,42],"been":[3,17,43,52],"known":[4],"as":[5,27,191],"ethnopharmacologically":[6],"valuable":[7],"mushroom":[8],"in":[9,75,176],"Korea,":[10],"China,":[11],"and":[12,32,67,138,159,180],"Japan.":[13],"This":[14],"plant":[15],"has":[16,50],"reported":[18],"to":[19,94,122,125,132,155],"exhibit":[20],"a":[21,100,152,166,192],"variety":[22],"of":[23,39,47,70,77,85,98,119,150],"pharmacological":[24,37],"activities":[25],"such":[26],"antioxidative,":[28],"anticancer,":[29],"anti-inflammatory,":[30],"antidiabetic,":[31],"antiobesity":[33],"effects.":[34],"Although":[35],"numerous":[36],"potentials":[38],"spp.":[41],"demonstrated,":[44],"immunomodulatory":[45,58],"effect":[46,118],"bassiana":[49,90],"not":[51],"published":[53],"yet.":[54],"To":[55],"evaluate":[56],"its":[57,79],"activity,":[59],"macrophages":[60],"activated":[61],"by":[62,164],"lipopolysaccharide":[63],"(LPS)":[64],"were":[65],"employed":[66],"the":[68,96,113,148],"production":[69,175],"interleukin-12":[71],"(IL-12)":[72],"was":[73,92],"explored":[74],"terms":[76],"understanding":[78],"molecular":[80],"inhibitory":[81,117],"mechanism.":[82],"Seventy":[83],"percent":[84],"ethanol":[86],"extract":[87,171],"from":[88],"(Cb-EE)":[91],"able":[93],"suppress":[95],"expression":[97],"IL-12,":[99],"cytokine":[101],"regulating":[102],"interferon-\u03b3":[103],"(IFN-\u03b3)-producing":[104],"T":[105],"helper":[106],"type":[107],"1":[108],"(Th1)":[109],"polarization":[110],"response,":[111],"at":[112],"transcriptional":[114],"levels.":[115],"The":[116],"Cb-EE":[120,145,187],"seemed":[121],"be":[123,189],"due":[124],"activator":[126],"protein-1":[127],"(AP-1)":[128],"translocation":[129,158],"inhibition,":[130],"according":[131],"immunoblotting":[133],"analysis":[134],"with":[135,143],"nuclear":[136],"fraction":[137],"luciferase":[139],"assay.":[140],"In":[141],"agreement":[142],"this,":[144],"strongly":[146,162],"suppressed":[147,163,173],"phosphorylation":[149],"p38,":[151],"prime":[153],"signal":[154],"stimulate":[156],"AP-1":[157],"IL-12":[160],"production,":[161],"SB203580,":[165],"p38":[167],"inhibitor.":[168],"Furthermore,":[169],"this":[170],"also":[172],"IFN-\u03b3":[174],"both":[177],"phytohemaglutinin":[178],"A":[179],"LPS-activated":[181],"splenocytes.":[182],"Our":[183],"results":[184],"suggest":[185],"that":[186],"can":[188],"applied":[190],"Th1":[193],"response":[194],"regulatory":[195],"herbal":[196],"medicine.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}