{"id":"https://openalex.org/W2007790724","doi":"https://doi.org/10.1002/stem.5530110412","title":"Autocrine transforming growth factor \u03b21 blocks colony formation and progenitor cell generation by hemopoietic stem cells stimulated with steel factor","display_name":"Autocrine transforming growth factor \u03b21 blocks colony formation and progenitor cell generation by hemopoietic stem cells stimulated with steel factor","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2007790724","doi":"https://doi.org/10.1002/stem.5530110412","mag":"2007790724","pmid":"https://pubmed.ncbi.nlm.nih.gov/7691312"},"language":"en","primary_location":{"id":"doi:10.1002/stem.5530110412","doi":"https://doi.org/10.1002/stem.5530110412","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.5530110412","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321353","display_name":"RE Ploemacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Rob E. Ploemacher","raw_affiliation_strings":["Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111436007","display_name":"P. L. van Soest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter L. Van Soest","raw_affiliation_strings":["Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035909229","display_name":"Adrie Boudewijn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Adrie Boudewijn","raw_affiliation_strings":["Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109321353"],"corresponding_institution_ids":["https://openalex.org/I913958620"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":2.869,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.90610255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"4","first_page":"336","last_page":"347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.75},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9480000138282776},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8569999933242798},{"id":"https://openalex.org/keywords/interleukin-11","display_name":"interleukin-11","score":0.9869999885559082},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cfu-s","display_name":"CFU-S","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hepatic-stellate-cell-activation","display_name":"hepatic stellate cell activation","score":0.699999988079071},{"id":"https://openalex.org/keywords/hsc-quiescence","display_name":"HSC quiescence","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hsc-proliferation","display_name":"HSC proliferation","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2779157386","wikidata":"https://www.wikidata.org/wiki/Q43499","display_name":"Erasmus+","level":3,"score":0.9262317419052124},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.6925057172775269},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6666237115859985},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5410479307174683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5289863348007202},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4948810935020447},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.48173049092292786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3911142945289612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2553523778915405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.234022319316864},{"id":"https://openalex.org/C52119013","wikidata":"https://www.wikidata.org/wiki/Q50637","display_name":"Art history","level":1,"score":0.15612095594406128},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12565678358078003},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.11994868516921997},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.09950676560401917},{"id":"https://openalex.org/C52069626","wikidata":"https://www.wikidata.org/wiki/Q4692","display_name":"The Renaissance","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016298","descriptor_name":"Hematopoietic Cell Growth Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016298","descriptor_name":"Hematopoietic Cell Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019089","descriptor_name":"Stem Cell Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/stem.5530110412","doi":"https://doi.org/10.1002/stem.5530110412","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.5530110412","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},{"id":"pmid:7691312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7691312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W72367593","https://openalex.org/W110506942","https://openalex.org/W133768150","https://openalex.org/W273564206","https://openalex.org/W329540900","https://openalex.org/W1222115765","https://openalex.org/W1500033451","https://openalex.org/W1517900110","https://openalex.org/W1566946791","https://openalex.org/W1921728185","https://openalex.org/W1974885640","https://openalex.org/W1975276441","https://openalex.org/W1976861055","https://openalex.org/W1977494906","https://openalex.org/W1982047651","https://openalex.org/W2004650098","https://openalex.org/W2008634652","https://openalex.org/W2023552518","https://openalex.org/W2031179453","https://openalex.org/W2040854254","https://openalex.org/W2049363137","https://openalex.org/W2068517158","https://openalex.org/W2076287231","https://openalex.org/W2081025616","https://openalex.org/W2091298934","https://openalex.org/W2113112343","https://openalex.org/W2149295197","https://openalex.org/W2166030007","https://openalex.org/W2168146165","https://openalex.org/W2265597917","https://openalex.org/W2395455593","https://openalex.org/W2399395081","https://openalex.org/W2410389417","https://openalex.org/W2410697197","https://openalex.org/W2414951805","https://openalex.org/W2419668340","https://openalex.org/W2420100774","https://openalex.org/W2427804383","https://openalex.org/W2467694779"],"related_works":["https://openalex.org/W2033631618","https://openalex.org/W2464999676","https://openalex.org/W1980793257","https://openalex.org/W2147376659","https://openalex.org/W2166658568","https://openalex.org/W2470035495","https://openalex.org/W2003542217","https://openalex.org/W19985982","https://openalex.org/W2058655873","https://openalex.org/W1921728185"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,24,45,59,74,90,103,114,147,198,203,215,232,246,249,256,267,282],"Steel":[3],"Factor":[4],"(SF)":[5],"to":[6,78,105,127,234],"stimulate":[7,235],"colony":[8,130,133,139,175],"formation":[9,113],"and":[10,36,119,135,137,168,181,286],"progenitor":[11,67],"cell":[12,68,117,167],"generation":[13,69],"by":[14,273],"hemopoietic":[15],"stem":[16],"cells":[17,261],"(HSCs)":[18],"in":[19,21,42,55,71,87],"vitro":[20],"the":[22,43,72,88,97,101,111,162,213,216,230,240,247,278],"absence":[23,89],"interleukin":[25],"3":[26],"(IL-3)":[27],"was":[28,31,159,194],"investigated.":[29],"IL-3":[30,158],"required":[32],"for":[33,227,242],"HSC":[34,149,187,200,236,250,268],"proliferation,":[35,237],"no":[37],"or":[38,49,54,125,208,280],"restricted":[39],"proliferation":[40],"occurred":[41],"presence":[44,73,102],"SF,":[46],"IL-6,":[47,123],"IL-11,":[48,124],"IL-12":[50,126],"as":[51,291,299],"single":[52],"factors":[53],"combination.":[56],"Neutralizing":[57],"concentrations":[58],"anti-transforming":[60],"growth":[61,294],"factor":[62,295],"(TGF)-beta":[63],"1":[64,94,193,218],"antibodies":[65,104],"enhanced":[66],"2-3-fold":[70],"IL-3,":[75],"but":[76],"75":[77],"over":[79],"300-fold":[80],"when":[81,157],"cultures":[82,146],"contained":[83],"at":[84],"least":[85],"SF":[86,108,120,233,288],"IL-3.":[91],"Exogenous":[92],"TGF-beta":[93,106,192,284],"fully":[95],"abrogated":[96],"antibody":[98],"effects.":[99],"In":[100],"1,":[107],"alone":[109],"stimulated":[110],"delayed":[112],"small":[115],"blast":[116],"colonies":[118,153],"synergized":[121],"with":[122,258],"greatly":[128],"hasten":[129],"formation,":[131],"enhance":[132],"number":[134],"size,":[136],"increase":[138],"forming":[140,176],"unit-culture":[141],"(CFU-C)":[142],"output":[143],"from":[144],"suspension":[145,163],"enriched":[148,184],"populations.":[150],"Secondary":[151],"CFU-C":[152],"were":[154],"significantly":[155],"larger":[156],"absent":[160],"during":[161],"culture":[164],"phase.":[165],"Single":[166],"limiting":[169],"dilution":[170],"analysis":[171],"using":[172],"a":[173,243,292,300],"homogenous":[174],"unit-spleen":[177],"(CFU-S)":[178],"day-12":[179],"population":[180],"an":[182,195],"800-fold":[183],"long-term":[185],"repopulating":[186],"fraction,":[188],"respectively,":[189],"indicated":[190],"that":[191],"autocrine":[196,283],"product":[197],"these":[199,221],"subsets.":[201],"Addition":[202],"nucleosides,":[204],"insulin,":[205],"extra":[206],"glucose,":[207],"serum":[209],"could":[210],"not":[211,263],"replace":[212],"effects":[214],"anti-TGF-beta":[217],"antibody.":[219],"While":[220],"data":[222],"offer":[223],"one":[224],"possible":[225],"explanation":[226],"reports":[228],"on":[229],"inability":[231],"they":[238],"present":[239],"basis":[241],"novel":[244],"model":[245],"regulation":[248],"activation":[251],"wherein:":[252],"1)":[253],"close-range":[254],"interactions":[255],"HSCs":[257,275],"mesenchymal":[259],"stromal":[260],"do":[262],"exclusively":[264,298],"determine":[265],"maintenance":[266],"quiescence;":[269],"2)":[270],"competence":[271],"acquisition":[272],"dormant":[274],"may":[276,289],"involve":[277],"down-regulation":[279],"inactivation":[281],"1;":[285],"3)":[287],"act":[290],"primary":[293],"rather":[296],"than":[297],"synergistic":[301],"cytokine.":[302]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
