{"id":"https://openalex.org/W2007790100","doi":"https://doi.org/10.1111/cbdd.12103","title":"Antibacterial and Synergy of Clavine Alkaloid Lysergol and its Derivatives Against Nalidixic Acid\u2010Resistant E scherichia coli","display_name":"Antibacterial and Synergy of Clavine Alkaloid Lysergol and its Derivatives Against Nalidixic Acid\u2010Resistant E scherichia coli","publication_year":2013,"publication_date":"2013-01-05","ids":{"openalex":"https://openalex.org/W2007790100","doi":"https://doi.org/10.1111/cbdd.12103","mag":"2007790100","pmid":"https://pubmed.ncbi.nlm.nih.gov/23290001"},"language":"en","primary_location":{"id":"doi:10.1111/cbdd.12103","doi":"https://doi.org/10.1111/cbdd.12103","is_oa":false,"landing_page_url":"https://doi.org/10.1111/cbdd.12103","pdf_url":null,"source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology & Drug Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111522748","display_name":"Anupam Maurya","orcid":"https://orcid.org/0000-0002-5365-4871","observed_orcids":["https://orcid.org/0000-0002-5365-4871"]},"institutions":[{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anupam Maurya","raw_affiliation_strings":["Department of Medicinal Chemistry; CSIR-Central Institute of Medicinal and Aromatic Plants; Lucknow; 226015; India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry; CSIR-Central Institute of Medicinal and Aromatic Plants; Lucknow; 226015; India","institution_ids":["https://openalex.org/I68145777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074623171","display_name":"Gaurav Raj Dwivedi","orcid":"https://orcid.org/0000-0003-4704-7116","observed_orcids":["https://orcid.org/0000-0003-4704-7116"]},"institutions":[{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gaurav R. Dwivedi","raw_affiliation_strings":["Department of Molecular Bioprospection CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow 226015 India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Bioprospection CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow 226015 India","institution_ids":["https://openalex.org/I68145777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085349807","display_name":"Mahendra P. Darokar","orcid":"https://orcid.org/0000-0002-4397-5516","observed_orcids":["https://orcid.org/0000-0002-4397-5516"]},"institutions":[{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahendra P. Darokar","raw_affiliation_strings":["Department of Molecular Bioprospection CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow 226015 India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Bioprospection CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow 226015 India","institution_ids":["https://openalex.org/I68145777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101471719","display_name":"Santosh K. Srivastava","orcid":"https://orcid.org/0000-0003-2558-6549","observed_orcids":["https://orcid.org/0000-0003-2558-6549"]},"institutions":[{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Santosh K. Srivastava","raw_affiliation_strings":["Department of Medicinal Chemistry; CSIR-Central Institute of Medicinal and Aromatic Plants; Lucknow; 226015; India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry; CSIR-Central Institute of Medicinal and Aromatic Plants; Lucknow; 226015; India","institution_ids":["https://openalex.org/I68145777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101471719"],"corresponding_institution_ids":["https://openalex.org/I68145777"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":1.7876,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.80343434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"81","issue":"4","first_page":"484","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.3009999990463257,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysergol","display_name":"lysergol","score":0.9850000143051147},{"id":"https://openalex.org/keywords/clavine-alkaloids","display_name":"clavine alkaloids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nalidixic-acid-resistance","display_name":"nalidixic acid resistance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9319999814033508},{"id":"https://openalex.org/keywords/semisynthetic-derivatives","display_name":"semisynthetic derivatives","score":0.7720000147819519},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8309999704360962},{"id":"https://openalex.org/keywords/antibacterial-drug-development","display_name":"antibacterial drug development","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2775876089","wikidata":"https://www.wikidata.org/wiki/Q281082","display_name":"Nalidixic acid","level":4,"score":0.9633958339691162},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6847082376480103},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.6821109056472778},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6722186803817749},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.624681293964386},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.6003400683403015},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5944730639457703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5101916790008545},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4639449119567871},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4502061903476715},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.37945181131362915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36340683698654175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3346005082130432},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11855578422546387},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004873","descriptor_name":"Ergolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004873","descriptor_name":"Ergolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004873","descriptor_name":"Ergolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004876","descriptor_name":"Ergot Alkaloids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004876","descriptor_name":"Ergot Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004876","descriptor_name":"Ergot Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009268","descriptor_name":"Nalidixic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/cbdd.12103","doi":"https://doi.org/10.1111/cbdd.12103","is_oa":false,"landing_page_url":"https://doi.org/10.1111/cbdd.12103","pdf_url":null,"source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology & Drug Design","raw_type":"journal-article"},{"id":"pmid:23290001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23290001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical biology & drug design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W72117635","https://openalex.org/W611976593","https://openalex.org/W1577015901","https://openalex.org/W1597874994","https://openalex.org/W1982240222","https://openalex.org/W1993279122","https://openalex.org/W2012764667","https://openalex.org/W2014427579","https://openalex.org/W2034436151","https://openalex.org/W2068811953","https://openalex.org/W2077371446","https://openalex.org/W2077886622","https://openalex.org/W2081946072","https://openalex.org/W2090766639","https://openalex.org/W2094420829","https://openalex.org/W2098695824","https://openalex.org/W2111156364","https://openalex.org/W2130913194","https://openalex.org/W2136723682","https://openalex.org/W2139049219","https://openalex.org/W2141481816","https://openalex.org/W2143337825","https://openalex.org/W2144501842","https://openalex.org/W2157226675","https://openalex.org/W2162363428","https://openalex.org/W2170713114","https://openalex.org/W2321441869"],"related_works":["https://openalex.org/W2029317866","https://openalex.org/W1604457436","https://openalex.org/W2279691529","https://openalex.org/W2794886482","https://openalex.org/W2087807389","https://openalex.org/W2415512374","https://openalex.org/W1967958961","https://openalex.org/W2914285052","https://openalex.org/W2037458512","https://openalex.org/W2045520617"],"abstract_inverted_index":{"Antibacterial":[0],"activity":[1,43],"of":[2,29,44,58,71,93,100,105,111,128,153,165],"lysergol":[3,78,114,134],"(1)":[4,35,79],"and":[5,10,24,36,75,80,84,113,115,119,135,139,151,177],"its":[6,81,116,136],"semi-synthetic":[7],"derivatives":[8,37,62,82,117,137],"(2-14)":[9,38],"their":[11,45],"synergy":[12],"with":[13,108],"the":[14,53,61,69,91,109,126],"conventional":[15],"antibiotic":[16],"nalidixic":[17,21,25],"acid":[18],"(NA)":[19],"against":[20,73,96],"acid-sensitive":[22],"(NASEC)":[23],"acid-resistant":[26],"(NAREC)":[27],"strains":[28,107],"Escherichia":[30],"coli":[31,102],"were":[32],"evaluated.":[33],"Lysergol":[34],"did":[39],"not":[40],"possess":[41],"antibacterial":[42,169],"own,":[46],"but":[47],"in":[48,68,90,168],"combination,":[49],"they":[50],"significantly":[51,124],"reduced":[52,122],"minimum":[54],"inhibitory":[55],"concentration":[56],"(MIC)":[57],"NA.":[59],"All":[60],"showed":[63],"two-":[64],"to":[65],"eightfold":[66,88],"reduction":[67],"MIC":[70,92],"NA":[72],"NAREC":[74],"NASEC.":[76],"Further,":[77],"10":[83,118,138],"11":[85,120,140],"brought":[86],"down":[87],"reductions":[89],"tetracycline":[94],"(TET)":[95],"multidrug-resistant":[97],"clinical":[98],"isolate":[99],"E.":[101],"(MDREC).":[103],"Treatment":[104],"these":[106],"combinations":[110],"antibiotics":[112],"(at":[121],"concentrations)":[123],"decreased":[125],"viability":[127],"cells.":[129],"In":[130],"an":[131],"another":[132],"observation,":[133],"inhibited":[141],"ATP-dependent":[142],"efflux":[143],"pumps,":[144],"which":[145],"was":[146],"evident":[147],"by":[148],"ATPase":[149],"inhibition":[150],"down-regulation":[152],"multidrug":[154],"ABC":[155],"transporter":[156],"ATP-binding":[157],"protein":[158],"(yojI)":[159],"gene.":[160],"These":[161],"results":[162],"may":[163],"be":[164],"great":[166],"help":[167],"drug":[170],"development":[171],"from":[172],"a":[173],"very":[174],"common,":[175],"inexpensive,":[176],"non-toxic":[178],"natural":[179],"product.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}