{"id":"https://openalex.org/W2007780372","doi":"https://doi.org/10.1074/jbc.m500478200","title":"A Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1 from Sedimentation Velocity Analysis","display_name":"A Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1 from Sedimentation Velocity Analysis","publication_year":2005,"publication_date":"2005-05-20","ids":{"openalex":"https://openalex.org/W2007780372","doi":"https://doi.org/10.1074/jbc.m500478200","mag":"2007780372","pmid":"https://pubmed.ncbi.nlm.nih.gov/15905170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2034521"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m500478200","doi":"https://doi.org/10.1074/jbc.m500478200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500478200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m500478200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091044424","display_name":"Kenneth H. Minor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth H. Minor","raw_affiliation_strings":["Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, USA","Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, USA","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, the","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075811004","display_name":"Christine R. Schar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine R. Schar","raw_affiliation_strings":["Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, the","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067465947","display_name":"Grant E. Blouse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant E. Blouse","raw_affiliation_strings":["Department of Pathology, Division of Biochemical Research, Henry Ford Health System, Detroit, Michigan 48202, the","Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Division of Biochemical Research, Henry Ford Health System, Detroit, Michigan 48202, the","institution_ids":["https://openalex.org/I154057602"]},{"raw_affiliation_string":"Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, the","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110875015","display_name":"Joseph D. Shore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Shore","raw_affiliation_strings":["Department of Pathology, Division of Biochemical Research, Henry Ford Health System, Detroit, Michigan 48202, the","Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Division of Biochemical Research, Henry Ford Health System, Detroit, Michigan 48202, the","institution_ids":["https://openalex.org/I154057602"]},{"raw_affiliation_string":"Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, the","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063870060","display_name":"Daniel A. Lawrence","orcid":"https://orcid.org/0000-0003-3126-1935","observed_orcids":["https://orcid.org/0000-0003-3126-1935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel A. Lawrence","raw_affiliation_strings":["Departments of Surgery and Physiology, University of Maryland School of Medicine, Rockville, Maryland 20855, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Physiology, University of Maryland School of Medicine, Rockville, Maryland 20855, the","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016735960","display_name":"Peter Schuck","orcid":"https://orcid.org/0000-0002-8859-6966","observed_orcids":["https://orcid.org/0000-0002-8859-6966"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210091794","display_name":"Office of the Director","ror":"https://ror.org/00fj8a872","country_code":"US","type":"other","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794"]},{"id":"https://openalex.org/I4210127607","display_name":"Office of Research Services","ror":"https://ror.org/02yrzyf97","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794","https://openalex.org/I4210127607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Schuck","raw_affiliation_strings":["Protein Biophysics Resource, Division of Bioengineering and Physical Science, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Biophysics Resource, Division of Bioengineering and Physical Science, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210091794","https://openalex.org/I4210127607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000590070","display_name":"Cynthia B. Peterson","orcid":"https://orcid.org/0000-0002-9220-753X","observed_orcids":["https://orcid.org/0000-0002-9220-753X"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cynthia B. Peterson","raw_affiliation_strings":["Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Cellular, and Molecular Biology and the Center of Excellence in Structural Biology, University of Tennessee, Knoxville, Tennessee 37996, the","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5000590070"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5047,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.8384036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"280","issue":"31","first_page":"28711","last_page":"28720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/stoichiometry","display_name":"stoichiometry","score":0.6650000214576721},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.5360000133514404},{"id":"https://openalex.org/keywords/pericellular-proteolysis","display_name":"pericellular proteolysis","score":0.796999990940094},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.9892160892486572},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.662844181060791},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.620231032371521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6116325259208679},{"id":"https://openalex.org/C1388644","wikidata":"https://www.wikidata.org/wiki/Q3132613","display_name":"Sedimentation coefficient","level":3,"score":0.5753303170204163},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45224887132644653},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.43076038360595703},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.41519659757614136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40917813777923584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40444403886795044},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33443957567214966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2818463146686554},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2571575939655304},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1512562334537506},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.1443871259689331},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12330013513565063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10806763172149658}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m500478200","doi":"https://doi.org/10.1074/jbc.m500478200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500478200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15905170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15905170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2034521","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2034521","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.lsu.edu:biosci_pubs-3898","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/biosci_pubs/2899","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:repository.lsu.edu:biosci_pubs-3898","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/biosci_pubs/2899","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m500478200","doi":"https://doi.org/10.1074/jbc.m500478200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m500478200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6919074082","display_name":null,"funder_award_id":"HL-50676","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8342973056","display_name":"Macromolecular Interactions of Human Vitronectin","funder_award_id":"R01HL050676","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W12975920","https://openalex.org/W15186908","https://openalex.org/W15890236","https://openalex.org/W160172706","https://openalex.org/W175798264","https://openalex.org/W1486952955","https://openalex.org/W1493779021","https://openalex.org/W1539115017","https://openalex.org/W1548286725","https://openalex.org/W1562197596","https://openalex.org/W1565197201","https://openalex.org/W1589957034","https://openalex.org/W1848943739","https://openalex.org/W1926488772","https://openalex.org/W1963843867","https://openalex.org/W1966103892","https://openalex.org/W1966581756","https://openalex.org/W1967654455","https://openalex.org/W1971400041","https://openalex.org/W1971670006","https://openalex.org/W1973474133","https://openalex.org/W1975317507","https://openalex.org/W1976221474","https://openalex.org/W1981019360","https://openalex.org/W1983256441","https://openalex.org/W1988118936","https://openalex.org/W1991421191","https://openalex.org/W1992451189","https://openalex.org/W1993203805","https://openalex.org/W1996906428","https://openalex.org/W1999746361","https://openalex.org/W2000268063","https://openalex.org/W2001795898","https://openalex.org/W2002082738","https://openalex.org/W2005113904","https://openalex.org/W2009805538","https://openalex.org/W2015957057","https://openalex.org/W2018961364","https://openalex.org/W2023035897","https://openalex.org/W2023856400","https://openalex.org/W2027946396","https://openalex.org/W2030390916","https://openalex.org/W2032660941","https://openalex.org/W2032692657","https://openalex.org/W2038139797","https://openalex.org/W2045680380","https://openalex.org/W2048653605","https://openalex.org/W2051861330","https://openalex.org/W2057156538","https://openalex.org/W2060321450","https://openalex.org/W2061346634","https://openalex.org/W2064178969","https://openalex.org/W2067388627","https://openalex.org/W2071363357","https://openalex.org/W2071742365","https://openalex.org/W2078134722","https://openalex.org/W2078142004","https://openalex.org/W2083945745","https://openalex.org/W2084330742","https://openalex.org/W2093376621","https://openalex.org/W2095847870","https://openalex.org/W2096487443","https://openalex.org/W2100445407","https://openalex.org/W2102004159","https://openalex.org/W2102577298","https://openalex.org/W2109839308","https://openalex.org/W2118152677","https://openalex.org/W2128635872","https://openalex.org/W2137081005","https://openalex.org/W2163449711","https://openalex.org/W2163526194","https://openalex.org/W2166508086","https://openalex.org/W2177719047","https://openalex.org/W2231047350","https://openalex.org/W2274344541","https://openalex.org/W2333642109","https://openalex.org/W2408098338","https://openalex.org/W2474289101"],"related_works":["https://openalex.org/W2027946396","https://openalex.org/W2070014993","https://openalex.org/W1991421191","https://openalex.org/W2074955423","https://openalex.org/W1531765010","https://openalex.org/W1582391412","https://openalex.org/W2039393403","https://openalex.org/W2092239758","https://openalex.org/W185656008","https://openalex.org/W2094716808"],"abstract_inverted_index":{"Plasminogen":[0],"activator":[1],"inhibitor-1":[2],"(PAI-1)":[3],"and":[4,16,26,47,68,73,144,162],"vitronectin":[5,163,183],"are":[6,24],"cofactors":[7],"involved":[8],"in":[9,65,84,97,125],"pathological":[10],"conditions":[11],"such":[12],"as":[13],"injury,":[14],"inflammation,":[15],"cancer,":[17],"during":[18],"which":[19],"local":[20],"levels":[21],"of":[22,86,109,121,177,182,197,207],"PAI-1":[23,161],"increased":[25],"the":[27,77,98,119,122,126,178,186,201,205],"active":[28],"serpin":[29],"forms":[30,168],"complexes":[31,35,63,128],"with":[32,76,193],"vitronectin.":[33],"These":[34],"become":[36],"deposited":[37],"into":[38,165],"surrounding":[39],"tissue":[40],"matrices,":[41],"where":[42],"they":[43],"regulate":[44],"cell":[45],"adhesion":[46],"pericellular":[48],"proteolysis.":[49],"The":[50],"mechanism":[51],"for":[52,204],"their":[53],"co-localization":[54],"has":[55],"not":[56],"been":[57],"elucidated.":[58],"We":[59],"hypothesize":[60],"that":[61,160,172],"PAI-1-vitronectin":[62,106,191],"form":[64,185],"a":[66,81,113,170,194],"stepwise":[67],"concentration-dependent":[69],"fashion":[70],"via":[71,169],"1:1":[72],"2:1":[74,78,187,190],"intermediates,":[75],"complex":[79],"serving":[80],"key":[82,202],"role":[83],"assembly":[85,206],"higher":[87,166,208],"order":[88,167,209],"complexes.":[89,107,210],"To":[90],"test":[91],"this":[92],"hypothesis,":[93],"sedimentation":[94,110,195],"velocity":[95],"experiments":[96],"analytical":[99],"ultracentrifuge":[100],"were":[101],"performed":[102],"to":[103,117,184],"identify":[104],"different":[105],"Analysis":[108],"data":[111],"invoked":[112],"novel":[114],"multisignal":[115],"method":[116],"discern":[118],"stoichiometry":[120],"two":[123,179],"proteins":[124],"higher-order":[127],"formed":[129],"(Balbo,":[130],"A.,":[131,137,140],"Minor,":[132],"K.":[133],"H.,":[134],"Velikovsky,":[135],"C.":[136,142],"Mariuzza,":[138],"R.":[139],"Peterson,":[141],"B.,":[143],"Schuck,":[145],"P.":[146],"(2005)":[147],"Proc.":[148],"Natl.":[149],"Acad.":[150],"Sci.":[151],"U.":[152],"S.":[153],"A.":[154],"102,":[155],"81-86).":[156],"Our":[157],"results":[158],"demonstrate":[159],"assemble":[164],"pathway":[171],"is":[173,200],"triggered":[174],"upon":[175],"saturation":[176],"PAI-1-binding":[180],"sites":[181],"complex.":[188],"This":[189],"complex,":[192],"coefficient":[196],"6.5":[198],"S,":[199],"intermediate":[203]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}