{"id":"https://openalex.org/W2007758952","doi":"https://doi.org/10.1016/s0048-9697(01)00864-6","title":"Effects of coxsackievirus B3 infection on the acute-phase protein metallothionein and on cytochrome P-4501A1 involved in the detoxification processes of TCDD in the mouse","display_name":"Effects of coxsackievirus B3 infection on the acute-phase protein metallothionein and on cytochrome P-4501A1 involved in the detoxification processes of TCDD in the mouse","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2007758952","doi":"https://doi.org/10.1016/s0048-9697(01)00864-6","mag":"2007758952","pmid":"https://pubmed.ncbi.nlm.nih.gov/11846173"},"language":"en","primary_location":{"id":"doi:10.1016/s0048-9697(01)00864-6","doi":"https://doi.org/10.1016/s0048-9697(01)00864-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0048-9697(01)00864-6","pdf_url":null,"source":{"id":"https://openalex.org/S86852077","display_name":"The Science of The Total Environment","issn_l":"0048-9697","issn":["0048-9697","1879-1026"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science of The Total Environment","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2007758952"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042018333","display_name":"Eva Funseth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eva Funseth","raw_affiliation_strings":["Department of Medical Sciences, Uppsala University Hospital, Sweden","Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Uppsala University Hospital, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030847272","display_name":"Martin P\u00e5hlman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1309171123","display_name":"National Food Administration","ror":"https://ror.org/02b1qqv62","country_code":"SE","type":"government","lineage":["https://openalex.org/I1309171123"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Martin P\u00e5hlman","raw_affiliation_strings":["Toxicology Division, Swedish National Food Administration, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology Division, Swedish National Food Administration, Uppsala, Sweden","institution_ids":["https://openalex.org/I1309171123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078557164","display_name":"Maija\u2010Leena Eloranta","orcid":"https://orcid.org/0000-0002-8454-1351","observed_orcids":["https://orcid.org/0000-0002-8454-1351"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maija-Leena Eloranta","raw_affiliation_strings":["Department of Veterinary Microbiology, Division of Immunology, Swedish University of Agricultural Sciences, Biomedical Centre, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Division of Immunology, Swedish University of Agricultural Sciences, Biomedical Centre, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113530211","display_name":"G\u00f6ran Friman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G\u00f6ran Friman","raw_affiliation_strings":["Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111637568","display_name":"Nils\u2010Gunnar Ilb\u00e4ck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1309171123","display_name":"National Food Administration","ror":"https://ror.org/02b1qqv62","country_code":"SE","type":"government","lineage":["https://openalex.org/I1309171123"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Nils-Gunnar Ilb\u00e4ck","raw_affiliation_strings":["Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden","Toxicology Division, Swedish National Food Administration, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Toxicology Division, Swedish National Food Administration, Uppsala, Sweden","institution_ids":["https://openalex.org/I1309171123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111637568"],"corresponding_institution_ids":["https://openalex.org/I1309171123","https://openalex.org/I1342360035"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":1.161,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.75708381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"284","issue":"1-3","first_page":"37","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.385699987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.385699987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.29030001163482666,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coxsackievirus-b3","display_name":"coxsackievirus B3","score":0.9700000286102295},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.8040000200271606},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":1.0},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tcdd","display_name":"TCDD","score":0.6710000038146973},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7269999980926514},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":1.0},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.5329999923706055},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.44999998807907104},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.9100000262260437},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.6589999794960022},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.3970000147819519},{"id":"https://openalex.org/keywords/a-j-mice","display_name":"A/J mice","score":0.6330000162124634},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.414000004529953},{"id":"https://openalex.org/keywords/interferon-inducers","display_name":"interferon inducers","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.8236426711082458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5421280860900879},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.49350273609161377},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.48154833912849426},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4759009778499603},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4746454358100891},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4643571376800537},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4508490562438965},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4278796911239624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4159199595451355},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.41491344571113586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4125925600528717},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.41246476769447327},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35790061950683594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30095964670181274},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28767794370651245},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.26036977767944336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2104872465133667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17157623171806335},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.08377078175544739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003384","descriptor_name":"Coxsackievirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0048-9697(01)00864-6","doi":"https://doi.org/10.1016/s0048-9697(01)00864-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0048-9697(01)00864-6","pdf_url":null,"source":{"id":"https://openalex.org/S86852077","display_name":"The Science of The Total Environment","issn_l":"0048-9697","issn":["0048-9697","1879-1026"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science of The Total Environment","raw_type":"journal-article"},{"id":"pmid:11846173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11846173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Science of the total environment","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W57077356","https://openalex.org/W191708048","https://openalex.org/W1499512474","https://openalex.org/W1520164477","https://openalex.org/W1538199768","https://openalex.org/W1597192845","https://openalex.org/W1816869536","https://openalex.org/W1867220640","https://openalex.org/W1967794994","https://openalex.org/W1968279495","https://openalex.org/W1981066689","https://openalex.org/W1984490307","https://openalex.org/W1985985668","https://openalex.org/W1987129664","https://openalex.org/W1993711874","https://openalex.org/W1994715363","https://openalex.org/W1998928723","https://openalex.org/W2010973636","https://openalex.org/W2011954802","https://openalex.org/W2014281089","https://openalex.org/W2019743925","https://openalex.org/W2020668476","https://openalex.org/W2029537473","https://openalex.org/W2032458072","https://openalex.org/W2032748187","https://openalex.org/W2034022565","https://openalex.org/W2035812617","https://openalex.org/W2035944386","https://openalex.org/W2036070813","https://openalex.org/W2036082570","https://openalex.org/W2036933659","https://openalex.org/W2038565043","https://openalex.org/W2050542881","https://openalex.org/W2053739706","https://openalex.org/W2057830862","https://openalex.org/W2057900414","https://openalex.org/W2075770312","https://openalex.org/W2092839327","https://openalex.org/W2093295695","https://openalex.org/W2093546975","https://openalex.org/W2094830038","https://openalex.org/W2103899710","https://openalex.org/W2106879244","https://openalex.org/W2119881367","https://openalex.org/W2161807318","https://openalex.org/W2198853443","https://openalex.org/W2267712340","https://openalex.org/W2278596438","https://openalex.org/W2287553067","https://openalex.org/W2289081051","https://openalex.org/W2327976693","https://openalex.org/W2336139768","https://openalex.org/W2409710375","https://openalex.org/W2415634187","https://openalex.org/W2417279329","https://openalex.org/W3135007396","https://openalex.org/W6695982884","https://openalex.org/W6703525320","https://openalex.org/W6714308950","https://openalex.org/W6715991348"],"related_works":["https://openalex.org/W2080908956","https://openalex.org/W2032748187","https://openalex.org/W2019342944","https://openalex.org/W2019743925","https://openalex.org/W2075770312","https://openalex.org/W2002738750","https://openalex.org/W425064143","https://openalex.org/W631293079","https://openalex.org/W2035944386","https://openalex.org/W2419053498"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}