{"id":"https://openalex.org/W2007755551","doi":"https://doi.org/10.1136/jnnp-2014-309032.292","title":"M20 Activation Of The Trkb Receptor Pathway Using A Novel Monoclonal Antibody Agonist: Implications For The Treatment Of Huntington's Disease","display_name":"M20 Activation Of The Trkb Receptor Pathway Using A Novel Monoclonal Antibody Agonist: Implications For The Treatment Of Huntington's Disease","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2007755551","doi":"https://doi.org/10.1136/jnnp-2014-309032.292","mag":"2007755551"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp-2014-309032.292","doi":"https://doi.org/10.1136/jnnp-2014-309032.292","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2014-309032.292","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027284944","display_name":"Nikisha Carty","orcid":"https://orcid.org/0000-0002-0824-3897","observed_orcids":["https://orcid.org/0000-0002-0824-3897"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Carty","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Schmidt","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001296928","display_name":"Galina Bursow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Bursow","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060246786","display_name":"Tom Schwagarus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Schwagarus","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Graff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Graff","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108204225","display_name":"Ewa Damrath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Damrath","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057561859","display_name":"Kirsten Kuhlbrodt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Kuhlbrodt","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Kohler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kohler","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031153383","display_name":"S. Koeplin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Koeplin","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Salomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Salomon","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111267076","display_name":"Stefan J\u00e4ger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Jager","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010043658","display_name":"Mark J. Gemkow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Gemkow","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113621534","display_name":"H. von der Kammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. von der Kammer","raw_affiliation_strings":["Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]},{"raw_affiliation_string":"1Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany (Corp. HQ)","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083770969","display_name":"John Wityak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802085568","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802085568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Wityak","raw_affiliation_strings":["CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA","2CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA","institution_ids":["https://openalex.org/I2802085568"]},{"raw_affiliation_string":"2CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA","institution_ids":["https://openalex.org/I2802085568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036509357","display_name":"Ignacio Mu\u00f1oz-Sanju\u00e1n","orcid":"https://orcid.org/0000-0003-0353-3577","observed_orcids":["https://orcid.org/0000-0003-0353-3577"]},"institutions":[{"id":"https://openalex.org/I2802085568","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802085568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Munoz-Sanjuan","raw_affiliation_strings":["CHDI Management/CHDI Foundation, 300 Alexander Park, Suite 110, Princeton, NJ 08540, USA","3CHDI Management/CHDI Foundation, 300 Alexander Park, Suite 110, Princeton, NJ 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHDI Management/CHDI Foundation, 300 Alexander Park, Suite 110, Princeton, NJ 08540, USA","institution_ids":["https://openalex.org/I2802085568"]},{"raw_affiliation_string":"3CHDI Management/CHDI Foundation, 300 Alexander Park, Suite 110, Princeton, NJ 08540, USA","institution_ids":["https://openalex.org/I2802085568"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112157961","display_name":"J. Bard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802085568","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802085568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bard","raw_affiliation_strings":["CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA","2CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA","institution_ids":["https://openalex.org/I2802085568"]},{"raw_affiliation_string":"2CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 100, Los Angeles, CA 90045, USA","institution_ids":["https://openalex.org/I2802085568"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"Suppl 1","first_page":"A101","last_page":"A101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trkb-receptor","display_name":"TrkB receptor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/bdnf-trkb-signaling","display_name":"BDNF/TrkB signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mutant-huntingtin","display_name":"mutant huntingtin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/striatal-neurons","display_name":"striatal neurons","score":0.878000020980835},{"id":"https://openalex.org/keywords/trkb-phosphorylation","display_name":"TrkB phosphorylation","score":0.843999981880188},{"id":"https://openalex.org/keywords/neurotrophin-signaling","display_name":"neurotrophin signaling","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.9753352403640747},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.7167631387710571},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6088193655014038},{"id":"https://openalex.org/C171034665","wikidata":"https://www.wikidata.org/wiki/Q14897694","display_name":"Tropomyosin receptor kinase A","level":4,"score":0.6019212603569031},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5100141763687134},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.4970593750476837},{"id":"https://openalex.org/C79186569","wikidata":"https://www.wikidata.org/wiki/Q14897880","display_name":"Tropomyosin receptor kinase C","level":5,"score":0.482340544462204},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4590436816215515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4515973925590515},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.4249500036239624},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3826761543750763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.376258909702301},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.3674779534339905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34855809807777405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34143003821372986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1478840410709381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11068904399871826},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05351829528808594},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.0},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jnnp-2014-309032.292","doi":"https://doi.org/10.1136/jnnp-2014-309032.292","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2014-309032.292","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:open-archive.highwire.org:jnnp:85/Suppl_1/A101-b","doi":null,"is_oa":false,"landing_page_url":"http://jnnp.bmj.com/cgi/content/short/85/Suppl_1/A101-b","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2036966153","https://openalex.org/W2131091928","https://openalex.org/W2102274021","https://openalex.org/W4386169012","https://openalex.org/W2140572389","https://openalex.org/W2314644980","https://openalex.org/W1991543633","https://openalex.org/W2018254952","https://openalex.org/W1995051993","https://openalex.org/W2058875286"],"abstract_inverted_index":{"Background":[0],"Huntington\u2019s":[1],"disease":[2,8],"(HD)":[3],"is":[4,60],"a":[5,11,26,61,196],"debilitating":[6],"neurodegenerative":[7],"marked":[9],"by":[10,110],"trinucleotide":[12],"repeat":[13],"expansion":[14],"in":[15,37,65,86,107,143,152,199,206,266,283],"the":[16,54,66,108,124,138,200,213,230,258,267,271,284],"huntingtin":[17,29],"gene":[18,113],"(HTT)":[19],"that":[20,35],"might":[21],"lead":[22],"to":[23,45,83,102,136,219,237,250],"production":[24],"of":[25,53,72,77,105,126,171,178,202,209,232,261,273],"pathogenic":[27],"mutant":[28],"protein":[30],"(mHTT).":[31],"Recent":[32],"evidence":[33],"suggests":[34],"alterations":[36],"neurotrophin":[38],"tyrosine":[39,55],"kinase":[40,56],"receptor":[41,59,140,155],"signalling":[42,141,281],"pathways":[43],"contribute":[44],"HD":[46,88,94,285],"pathophysiology.":[47],"Brain-derived":[48],"neurotrophic":[49],"factor":[50],"(BDNF)-mediated":[51],"activation":[52],"B":[57],"(TrkB)":[58],"critical":[62],"component":[63],"involved":[64],"survival,":[67],"differentiation":[68],"and":[69,93,115,160,180,222,269],"synaptic":[70],"plasticity":[71],"striatal":[73,207],"neurons.":[74],"Reduced":[75],"levels":[76,104,231],"BDNF":[78,106],"have":[79],"been":[80,100],"previously":[81],"reported":[82],"be":[84],"observed":[85,205],"both":[87],"post":[89,188,194,228],"mortem":[90],"brain":[91],"tissue":[92],"mouse":[95,128],"models.":[96],"Furthermore,":[97],"mHTT":[98],"has":[99],"shown":[101],"reduce":[103],"striatum":[109],"inhibiting":[111],"its":[112],"expression":[114],"cortico-striatal":[116],"trafficking.":[117],"Aims":[118],"In":[119],"this":[120],"study,":[121],"we":[122],"explore":[123],"capacity":[125],"novel":[127],"TrkB":[129,134,139,148,173,203,215,233,263],"agonistic":[130],"monoclonal":[131],"antibodies":[132,265],"(mAb":[133],"agonist)":[135],"activate":[137],"pathway":[142],"vivo.":[144],"Methods":[145],"The":[146],"mAb":[147,172,214,262],"agonists":[149],"were":[150,181,235,243],"tested":[151],"vitroto":[153],"confirm":[154,251],"selectivity,":[156],"efficient":[157],"binding":[158],"affinity":[159],"functional":[161,259],"activity.":[162],"Subsequently,":[163],"wild":[164],"type":[165],"mice":[166,210],"received":[167],"intrastriatal":[168],"bolus":[169],"injections":[170],"agonist":[174,216,264],"at":[175,183],"6":[176],"weeks":[177],"age":[179],"sacrificed":[182],"four":[184],"different":[185],"time":[186],"points":[187],"injection.":[189],"Results":[190],"At":[191,225],"30":[192],"min":[193],"injection,":[195,229],"significant":[197],"increase":[198],"phosphorylation":[201,234],"was":[204],"neurons":[208],"treated":[211,221],"with":[212],"when":[217],"compared":[218],"vehicle":[220],"non-treated":[223],"animals.":[224],"4":[226],"h":[227],"returned":[236],"baseline":[238],"levels.":[239],"Quantitative":[240],"western":[241],"blots":[242],"also":[244],"performed":[245],"as":[246],"an":[247,274],"orthogonal":[248],"method":[249],"immunohistochemical":[252],"results.":[253],"Overall,":[254],"our":[255],"findings":[256],"demonstrate":[257],"activity":[260,282],"CNS":[268],"establish":[270],"potential":[272],"immuotherapeutic":[275],"approach":[276],"for":[277],"restoring":[278],"aberrant":[279],"BDNF-TrkB":[280],"brain.":[286]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
