{"id":"https://openalex.org/W2007753564","doi":"https://doi.org/10.1016/s1054-8807(01)00095-3","title":"Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells","display_name":"Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2007753564","doi":"https://doi.org/10.1016/s1054-8807(01)00095-3","mag":"2007753564","pmid":"https://pubmed.ncbi.nlm.nih.gov/11755377"},"language":"en","primary_location":{"id":"doi:10.1016/s1054-8807(01)00095-3","doi":"https://doi.org/10.1016/s1054-8807(01)00095-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1054-8807(01)00095-3","pdf_url":null,"source":{"id":"https://openalex.org/S176609843","display_name":"Cardiovascular Pathology","issn_l":"1054-8807","issn":["1054-8807","1879-1336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110096493","display_name":"Johannes Ruef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johannes Ruef","raw_affiliation_strings":["Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115, Heidelberg, Germany. johannes_ruef@med.uni-heidelberg.de","Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115, Heidelberg, Germany. johannes_ruef@med.uni-heidelberg.de","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030654513","display_name":"Martin Moser","orcid":"https://orcid.org/0000-0002-0745-7447","observed_orcids":["https://orcid.org/0000-0002-0745-7447"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Moser","raw_affiliation_strings":["Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111762241","display_name":"W. K\u00fcbler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang K\u00fcbler","raw_affiliation_strings":["Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Heidelberg, Bergheimer Str. 58, D-69115 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015202871","display_name":"Christoph Bode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Bode","raw_affiliation_strings":["Division of Cardiology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110096493"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":4.183,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.93812171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"6","first_page":"311","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cytosolic-phospholipase-a2","display_name":"cytosolic phospholipase A2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.8989999890327454},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9700000286102295},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9490000009536743},{"id":"https://openalex.org/keywords/endothelin-a-receptor","display_name":"ETA receptor","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7350960373878479},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7344228029251099},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7258226871490479},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.6746894121170044},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6745280027389526},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.49724748730659485},{"id":"https://openalex.org/C2909649922","wikidata":"https://www.wikidata.org/wiki/Q106318493","display_name":"Endothelins","level":4,"score":0.476749986410141},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.46787142753601074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45475518703460693},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4392701983451843},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.43768101930618286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3807854950428009},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36761653423309326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2067631185054779},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.09115880727767944}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028441","descriptor_name":"F2-Isoprostanes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D028441","descriptor_name":"F2-Isoprostanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1054-8807(01)00095-3","doi":"https://doi.org/10.1016/s1054-8807(01)00095-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1054-8807(01)00095-3","pdf_url":null,"source":{"id":"https://openalex.org/S176609843","display_name":"Cardiovascular Pathology","issn_l":"1054-8807","issn":["1054-8807","1879-1336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Pathology","raw_type":"journal-article"},{"id":"pmid:11755377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11755377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology","raw_type":"Journal Article"},{"id":"pmh:oai:freidok.uni-freiburg.de:40971","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/40971","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cardiovascular Pathology. - 10, 6 (2001) , 311-315, ISSN: 1054-8807","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W94954592","https://openalex.org/W134737704","https://openalex.org/W156498367","https://openalex.org/W1536087975","https://openalex.org/W1548437752","https://openalex.org/W1791153000","https://openalex.org/W1972153352","https://openalex.org/W1975199357","https://openalex.org/W1978603134","https://openalex.org/W1984054161","https://openalex.org/W2000959758","https://openalex.org/W2005593895","https://openalex.org/W2005876444","https://openalex.org/W2007671598","https://openalex.org/W2008574812","https://openalex.org/W2013616551","https://openalex.org/W2016018685","https://openalex.org/W2016596925","https://openalex.org/W2020631276","https://openalex.org/W2027472953","https://openalex.org/W2027564114","https://openalex.org/W2029969503","https://openalex.org/W2038140079","https://openalex.org/W2040692157","https://openalex.org/W2045825531","https://openalex.org/W2053837324","https://openalex.org/W2058759502","https://openalex.org/W2058977087","https://openalex.org/W2071115174","https://openalex.org/W2071516643","https://openalex.org/W2074140711","https://openalex.org/W2092654095","https://openalex.org/W2125008605","https://openalex.org/W2135633069","https://openalex.org/W2141610498","https://openalex.org/W2143272819","https://openalex.org/W2148663698","https://openalex.org/W2149632020","https://openalex.org/W2153762158","https://openalex.org/W2155900030","https://openalex.org/W2162450083","https://openalex.org/W2162804111","https://openalex.org/W2163624012","https://openalex.org/W2171613935","https://openalex.org/W2202208218","https://openalex.org/W2285669587","https://openalex.org/W2317090307","https://openalex.org/W2337862026","https://openalex.org/W2396634461","https://openalex.org/W2417350687","https://openalex.org/W6603827592","https://openalex.org/W6632130388","https://openalex.org/W6683089747","https://openalex.org/W6687919084","https://openalex.org/W6712315236"],"related_works":["https://openalex.org/W2557070042","https://openalex.org/W2000208057","https://openalex.org/W2316110478","https://openalex.org/W2165751980","https://openalex.org/W2016596925","https://openalex.org/W1964071592","https://openalex.org/W2348766156","https://openalex.org/W7099657918","https://openalex.org/W2023578446","https://openalex.org/W2278566807"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}