{"id":"https://openalex.org/W2007706148","doi":"https://doi.org/10.1016/j.ehpc.2014.07.002","title":"Activating mutations of the oncogene EZH2 in cutaneous melanoma revealed by next generation sequencing","display_name":"Activating mutations of the oncogene EZH2 in cutaneous melanoma revealed by next generation sequencing","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2007706148","doi":"https://doi.org/10.1016/j.ehpc.2014.07.002","mag":"2007706148"},"language":"en","primary_location":{"id":"doi:10.1016/j.ehpc.2014.07.002","doi":"https://doi.org/10.1016/j.ehpc.2014.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ehpc.2014.07.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214330014200228/pdf","source":{"id":"https://openalex.org/S2898162792","display_name":"Human Pathology Case Reports","issn_l":"2214-3300","issn":["2214-3300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology: Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2214330014200228/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044405915","display_name":"Paul W. Harms","orcid":"https://orcid.org/0000-0002-0802-2883","observed_orcids":["https://orcid.org/0000-0002-0802-2883"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul W. Harms","raw_affiliation_strings":["Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054784668","display_name":"Alexandra C. Hristov","orcid":"https://orcid.org/0000-0002-1836-6591","observed_orcids":["https://orcid.org/0000-0002-1836-6591"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra C. Hristov","raw_affiliation_strings":["Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403320","display_name":"David Kim","orcid":"https://orcid.org/0000-0002-4755-2828","observed_orcids":["https://orcid.org/0000-0002-4755-2828"]},"institutions":[{"id":"https://openalex.org/I1315135799","display_name":"Marshfield Clinic","ror":"https://ror.org/025chrz76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315135799"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Kim","raw_affiliation_strings":["Marshfield Clinic, Marshfield, WI 54449, USA"],"raw_orcid":"https://orcid.org/0000-0002-4755-2828","affiliations":[{"raw_affiliation_string":"Marshfield Clinic, Marshfield, WI 54449, USA","institution_ids":["https://openalex.org/I1315135799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058395887","display_name":"Tobenna Anens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tobenna Anens","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035266638","display_name":"Michael J. Quist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Quist","raw_affiliation_strings":["Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113491883","display_name":"Javed Siddiqui","orcid":"https://orcid.org/0009-0004-8251-4829","observed_orcids":["https://orcid.org/0009-0004-8251-4829"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javed Siddiqui","raw_affiliation_strings":["Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110338890","display_name":"Shannon L. Carskadon","orcid":"https://orcid.org/0000-0002-6950-0308","observed_orcids":["https://orcid.org/0000-0002-6950-0308"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Carskadon","raw_affiliation_strings":["Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060849370","display_name":"Rohit Mehra","orcid":"https://orcid.org/0000-0002-6955-8884","observed_orcids":["https://orcid.org/0000-0002-6955-8884"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohit Mehra","raw_affiliation_strings":["Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016216331","display_name":"Douglas Randall Fullen","orcid":"https://orcid.org/0000-0002-2524-4509","observed_orcids":["https://orcid.org/0000-0002-2524-4509"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R. Fullen","raw_affiliation_strings":["Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103112079","display_name":"Timothy M. Johnson","orcid":"https://orcid.org/0000-0003-3466-3040","observed_orcids":["https://orcid.org/0000-0003-3466-3040"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy M. Johnson","raw_affiliation_strings":["Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003311852","display_name":"Arul M. Chinnaiyan","orcid":"https://orcid.org/0000-0001-9282-3415","observed_orcids":["https://orcid.org/0000-0001-9282-3415"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arul M. Chinnaiyan","raw_affiliation_strings":["Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042167871","display_name":"Nallasivam Palanisamy","orcid":"https://orcid.org/0000-0002-0633-9772","observed_orcids":["https://orcid.org/0000-0002-0633-9772"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nallasivam Palanisamy","raw_affiliation_strings":["Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":"https://orcid.org/0000-0002-0633-9772","affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Departments of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5042167871"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I4210117557","https://openalex.org/I4390039285"],"apc_list":{"value":750,"currency":"USD","value_usd":750},"apc_paid":{"value":750,"currency":"USD","value_usd":750},"fwci":0.5465,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63154569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"2","first_page":"21","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/activating-mutations","display_name":"activating mutations","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/braf-v600k","display_name":"BRAF V600K","score":0.9769999980926514},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.921999990940094},{"id":"https://openalex.org/keywords/epigenetic-repression","display_name":"epigenetic repression","score":0.6890000104904175},{"id":"https://openalex.org/keywords/coexisting-malignancies","display_name":"coexisting malignancies","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.920701801776886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6872184872627258},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6526397466659546},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5800398588180542},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4827110469341278},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.4668937921524048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46578943729400635},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.43720439076423645},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3962944746017456},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3583986759185791},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3072831332683563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22506144642829895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12077257037162781}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ehpc.2014.07.002","doi":"https://doi.org/10.1016/j.ehpc.2014.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ehpc.2014.07.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214330014200228/pdf","source":{"id":"https://openalex.org/S2898162792","display_name":"Human Pathology Case Reports","issn_l":"2214-3300","issn":["2214-3300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology: Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e9ecae430a3044439c4aa2b2925e7ff5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e9ecae430a3044439c4aa2b2925e7ff5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Pathology: Case Reports, Vol 1, Iss 2, Pp 21-28 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ehpc.2014.07.002","doi":"https://doi.org/10.1016/j.ehpc.2014.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ehpc.2014.07.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214330014200228/pdf","source":{"id":"https://openalex.org/S2898162792","display_name":"Human Pathology Case Reports","issn_l":"2214-3300","issn":["2214-3300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology: Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007706148.pdf","grobid_xml":"https://content.openalex.org/works/W2007706148.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1856564249","https://openalex.org/W1900973458","https://openalex.org/W1973628185","https://openalex.org/W1994158976","https://openalex.org/W1996487270","https://openalex.org/W2004380688","https://openalex.org/W2009096660","https://openalex.org/W2018308631","https://openalex.org/W2019564564","https://openalex.org/W2024373518","https://openalex.org/W2026196315","https://openalex.org/W2035000040","https://openalex.org/W2057065967","https://openalex.org/W2061587893","https://openalex.org/W2061846271","https://openalex.org/W2064469303","https://openalex.org/W2085864013","https://openalex.org/W2100365251","https://openalex.org/W2103557568","https://openalex.org/W2110567963","https://openalex.org/W2125496315","https://openalex.org/W2131040858","https://openalex.org/W2133040382","https://openalex.org/W2134471382","https://openalex.org/W2148217229","https://openalex.org/W2149793889","https://openalex.org/W2150677022","https://openalex.org/W2169810552","https://openalex.org/W2327772647"],"related_works":["https://openalex.org/W2936748048","https://openalex.org/W2291929727","https://openalex.org/W1969485334","https://openalex.org/W1873710893","https://openalex.org/W2000448910","https://openalex.org/W2070420541","https://openalex.org/W2492668375","https://openalex.org/W1503807344","https://openalex.org/W1965467019","https://openalex.org/W2890037676"],"abstract_inverted_index":{"Enhancer":[0],"of":[1,16,56],"zeste":[2],"homolog":[3],"2":[4],"(EZH2)":[5],"is":[6,22],"a":[7,54],"histone":[8],"methyltransferase":[9],"that":[10,59,81,118],"promotes":[11],"tumorigenesis":[12],"by":[13,67],"epigenetic":[14],"repression":[15],"tumor":[17,133],"suppressor":[18],"genes.":[19],"Although":[20],"EZH2":[21,28,42,62,85,111,121,145],"overexpressed":[23],"in":[24,34,45,92,124],"many":[25],"malignancies,":[26],"activating":[27,43,64,110,119],"mutations":[29,44,90,122],"have":[30],"been":[31],"described":[32],"predominantly":[33],"follicular":[35,79],"lymphoma":[36,80],"and":[37,87,103],"diffuse":[38],"large":[39],"B-cell":[40],"lymphoma.":[41],"melanoma":[46,58,107],"are":[47],"not":[48],"well":[49,71],"described.":[50],"Here,":[51],"we":[52,97],"report":[53],"case":[55],"cutaneous":[57,125],"displayed":[60],"an":[61],"(Y641S)":[63],"mutation":[65],"detected":[66],"transcriptome":[68],"sequencing":[69],"as":[70,72],"BRAF":[73,88],"(V600K).":[74],"The":[75],"patient":[76],"had":[77],"concurrent":[78],"lacked":[82],"both":[83],"the":[84,93,130],"(Y641)":[86],"(V600K)":[89],"present":[91],"patient's":[94],"melanoma.":[95],"Further,":[96],"screened":[98],"publicly":[99],"available":[100],"sequence":[101],"data":[102],"identified":[104],"four":[105],"additional":[106,116],"cases":[108],"harboring":[109],"mutation.":[112],"Our":[113],"findings":[114],"provide":[115],"evidence":[117],"recurrent":[120],"occur":[123],"melanoma,":[126],"to":[127,135,144],"our":[128],"knowledge":[129],"first":[131],"solid":[132],"shown":[134],"harbor":[136],"such":[137],"mutations.":[138],"These":[139],"tumors":[140],"may":[141],"be":[142],"amenable":[143],"inhibitor":[146],"therapy.":[147]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}