{"id":"https://openalex.org/W2007702854","doi":"https://doi.org/10.1016/j.intimp.2013.11.009","title":"Impaired and imbalanced cellular immunological status assessed in advanced cancer patients and restoration of the T cell immune status by adoptive T-cell immunotherapy","display_name":"Impaired and imbalanced cellular immunological status assessed in advanced cancer patients and restoration of the T cell immune status by adoptive T-cell immunotherapy","publication_year":2013,"publication_date":"2013-11-21","ids":{"openalex":"https://openalex.org/W2007702854","doi":"https://doi.org/10.1016/j.intimp.2013.11.009","mag":"2007702854","pmid":"https://pubmed.ncbi.nlm.nih.gov/24269583"},"language":"en","primary_location":{"id":"doi:10.1016/j.intimp.2013.11.009","doi":"https://doi.org/10.1016/j.intimp.2013.11.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.intimp.2013.11.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1567576913004177/pdf","source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1567576913004177/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000731862","display_name":"Atsutaka Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263801","display_name":"Medinet Co., Ltd. (Japan)","ror":"https://ror.org/003m9jr97","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405263801"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsutaka Noguchi","raw_affiliation_strings":["Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan; Medinet Co., Ltd., Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama 222-0033, Japan","Medinet Co., Ltd., Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama 222-0033, Japan","Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan; Medinet Co., Ltd., Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama 222-0033, Japan","institution_ids":["https://openalex.org/I4405263801"]},{"raw_affiliation_string":"Medinet Co., Ltd., Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama 222-0033, Japan","institution_ids":["https://openalex.org/I4405263801"]},{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toru Kaneko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toru Kaneko","raw_affiliation_strings":["Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056138720","display_name":"Keiko Naitoh","orcid":"https://orcid.org/0009-0002-4913-3261","observed_orcids":["https://orcid.org/0009-0002-4913-3261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiko Naitoh","raw_affiliation_strings":["Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029501184","display_name":"Mariko Saito","orcid":"https://orcid.org/0000-0001-9383-4458","observed_orcids":["https://orcid.org/0000-0001-9383-4458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masashi Saito","raw_affiliation_strings":["Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuro Iwai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuro Iwai","raw_affiliation_strings":["Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070855298","display_name":"Ryuji Maekawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263801","display_name":"Medinet Co., Ltd. (Japan)","ror":"https://ror.org/003m9jr97","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405263801"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuji Maekawa","raw_affiliation_strings":["Medinet Co., Ltd., Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama 222-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medinet Co., Ltd., Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama 222-0033, Japan","institution_ids":["https://openalex.org/I4405263801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083431844","display_name":"Takashi Kamigaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Kamigaki","raw_affiliation_strings":["Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103343791","display_name":"Shigenori Goto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shigenori Goto","raw_affiliation_strings":["Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan. Electronic address: goto@j-immunother.com","Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan. Electronic address: goto@j-immunother.com","institution_ids":[]},{"raw_affiliation_string":"Seta Clinic Group, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103343791"],"corresponding_institution_ids":[],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":{"value":3220,"currency":"USD","value_usd":3220},"fwci":1.3078,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.77042975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"90","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.13950000703334808,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0778999999165535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7429999709129333},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7711718678474426},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6236381530761719},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.6024220585823059},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5754985213279724},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5670117735862732},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5289444923400879},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.5036203265190125},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.46999678015708923},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.4642890691757202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45648667216300964},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.44827577471733093},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4365347921848297},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.4185112416744232},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.3106733560562134},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.260938435792923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24317526817321777}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.intimp.2013.11.009","doi":"https://doi.org/10.1016/j.intimp.2013.11.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.intimp.2013.11.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1567576913004177/pdf","source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:24269583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24269583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.intimp.2013.11.009","doi":"https://doi.org/10.1016/j.intimp.2013.11.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.intimp.2013.11.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1567576913004177/pdf","source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007702854.pdf","grobid_xml":"https://content.openalex.org/works/W2007702854.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W156969165","https://openalex.org/W1479844134","https://openalex.org/W1574254013","https://openalex.org/W1786792567","https://openalex.org/W1987853950","https://openalex.org/W1990260047","https://openalex.org/W1994850185","https://openalex.org/W1999181360","https://openalex.org/W2001452435","https://openalex.org/W2014184579","https://openalex.org/W2031693363","https://openalex.org/W2033734519","https://openalex.org/W2043460160","https://openalex.org/W2045225531","https://openalex.org/W2046749626","https://openalex.org/W2050437452","https://openalex.org/W2055625331","https://openalex.org/W2068273212","https://openalex.org/W2075131034","https://openalex.org/W2087277378","https://openalex.org/W2097995306","https://openalex.org/W2099657378","https://openalex.org/W2101653483","https://openalex.org/W2105400883","https://openalex.org/W2116378201","https://openalex.org/W2121642732","https://openalex.org/W2126302947","https://openalex.org/W2128848268","https://openalex.org/W2130011407","https://openalex.org/W2132923173","https://openalex.org/W2138002048","https://openalex.org/W2150678612","https://openalex.org/W2150950354","https://openalex.org/W2160117150","https://openalex.org/W2160834915","https://openalex.org/W2163985116","https://openalex.org/W2170805832","https://openalex.org/W2184262699","https://openalex.org/W2410313936","https://openalex.org/W2465756925"],"related_works":["https://openalex.org/W1956349642","https://openalex.org/W2125191382","https://openalex.org/W2124477929","https://openalex.org/W2374717927","https://openalex.org/W2030259772","https://openalex.org/W2138002048","https://openalex.org/W6189649","https://openalex.org/W2014527071","https://openalex.org/W23997070","https://openalex.org/W2411432563"],"abstract_inverted_index":{"Recent":[0],"progress":[1],"has":[2],"been":[3],"made":[4],"in":[5,91,113,127,142,145,155],"understanding":[6],"the":[7,17,32,50,177],"mechanisms":[8],"of":[9,20,31,35,76,99,107,135,163,179,193],"antitumor":[10],"immune":[11,18,153,211],"responses,":[12],"which":[13],"may":[14],"further":[15],"clarify":[16],"status":[19,34],"cancer":[21,156,165],"patients.":[22,157],"In":[23],"this":[24],"study,":[25],"we":[26],"performed":[27],"a":[28,150],"detailed":[29],"evaluation":[30],"immunological":[33],"47":[36,164],"patients":[37,92,114,128,143,166],"with":[38,52,94,116],"advanced":[39],"solid":[40],"cancer,":[41],"who":[42],"had":[43],"received":[44],"no":[45],"immunosuppressive":[46],"treatment,":[47],"and":[48,71,85,105,119,186,191,207],"compared":[49,93,115],"results":[51,148,200],"32":[53],"healthy":[54,95,131],"subjects.":[55,96,132],"Flow-cytometry":[56],"data":[57],"for":[58],"peripheral":[59,159],"blood":[60,160],"were":[61,88,125],"obtained":[62],"using":[63],"19":[64],"monoclonal":[65],"antibodies":[66],"against":[67],"various":[68],"cell":[69,81,172,181,210],"surface":[70],"intracellular":[72],"molecules.":[73],"Absolute":[74],"numbers":[75],"T":[77,80,101,109,123,171,180,195,209],"cells,":[78,84],"several":[79],"subsets,":[82,182],"B":[83,185],"NK":[86,137,187],"cells":[87,102,110,124,138,196],"significantly":[89,140],"decreased":[90,197],"The":[97,133,189],"percentage":[98,134,192],"CD27(+)CD45RA(+)":[100],"was":[103,111,139,167],"lower":[104,141],"that":[106,202],"CD27(-)CD45RA(-)":[108],"higher":[112],"controls.":[117,146],"Regulatory":[118],"type":[120],"2":[121],"helper":[122],"elevated":[126],"relative":[129],"to":[130],"perforin(+)":[136],"than":[144],"These":[147,199],"suggest":[149,201],"dysfunctional":[151],"anti-tumor":[152],"response":[154],"Furthermore,":[158],"from":[161],"26":[162],"analyzed":[168],"after":[169],"adoptive":[170],"immunotherapy":[173],"(ATI).":[174],"ATI":[175,203],"increased":[176],"number":[178,190],"but":[183],"not":[184],"cells.":[188],"regulatory":[194],"significantly.":[198],"can":[204],"restore":[205],"impaired":[206],"imbalanced":[208],"status.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}