{"id":"https://openalex.org/W2007697211","doi":"https://doi.org/10.1097/aog.0b013e3181bc6ab0","title":"Array Comparative Genomic Hybridization for Genetic Evaluation of Fetal Loss Between 10 and 20 Weeks of Gestation","display_name":"Array Comparative Genomic Hybridization for Genetic Evaluation of Fetal Loss Between 10 and 20 Weeks of Gestation","publication_year":2009,"publication_date":"2009-10-17","ids":{"openalex":"https://openalex.org/W2007697211","doi":"https://doi.org/10.1097/aog.0b013e3181bc6ab0","mag":"2007697211","pmid":"https://pubmed.ncbi.nlm.nih.gov/20168112"},"language":"en","primary_location":{"id":"doi:10.1097/aog.0b013e3181bc6ab0","doi":"https://doi.org/10.1097/aog.0b013e3181bc6ab0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aog.0b013e3181bc6ab0","pdf_url":null,"source":{"id":"https://openalex.org/S139838620","display_name":"Obstetrics and Gynecology","issn_l":"0029-7844","issn":["0029-7844","1873-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics &amp; Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111991692","display_name":"Jennifer E. Warren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I61474668","display_name":"ARUP Laboratories (United States)","ror":"https://ror.org/00c2tyx86","country_code":"US","type":"company","lineage":["https://openalex.org/I61474668"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E. Warren","raw_affiliation_strings":["From the Departments of Obstetrics and Gynecology, Genetics, and Pediatrics, University of Utah; and ARUP Laboratories, Salt Lake City, Utah","Obstetrics and Gynecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Obstetrics and Gynecology, Genetics, and Pediatrics, University of Utah; and ARUP Laboratories, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I61474668"]},{"raw_affiliation_string":"Obstetrics and Gynecology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042491895","display_name":"David Keith Turok","orcid":"https://orcid.org/0000-0002-6289-0542","observed_orcids":["https://orcid.org/0000-0002-6289-0542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David K. Turok","raw_affiliation_strings":["Obstetrics and Gynecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038941402","display_name":"Teresa M. Maxwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa M. Maxwell","raw_affiliation_strings":["Genetics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027135353","display_name":"Arthur R. Brothman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I61474668","display_name":"ARUP Laboratories (United States)","ror":"https://ror.org/00c2tyx86","country_code":"US","type":"company","lineage":["https://openalex.org/I61474668"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur R. Brothman","raw_affiliation_strings":["ARUP Laboratories, Salt Lake City, Utah","Pediatrics, University of Utah; and","Pediatrics, University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARUP Laboratories, Salt Lake City, Utah","institution_ids":["https://openalex.org/I61474668"]},{"raw_affiliation_string":"Pediatrics, University of Utah; and","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Pediatrics, University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059326304","display_name":"Robert M. Silver","orcid":"https://orcid.org/0000-0002-5794-3152","observed_orcids":["https://orcid.org/0000-0002-5794-3152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. Silver","raw_affiliation_strings":["Obstetrics and Gynecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4417,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.93840948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"114","issue":"5","first_page":"1093","last_page":"1102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-death","display_name":"fetal death","score":0.8009999990463257},{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.6240000128746033},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8299999833106995},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.550000011920929},{"id":"https://openalex.org/keywords/early-pregnancy","display_name":"early pregnancy","score":0.49000000953674316},{"id":"https://openalex.org/keywords/unexplained-pregnancy-loss","display_name":"unexplained pregnancy loss","score":0.6320000290870667},{"id":"https://openalex.org/keywords/bac-array","display_name":"BAC array","score":0.5170000195503235},{"id":"https://openalex.org/keywords/oligonucleotide-microarrays","display_name":"oligonucleotide microarrays","score":0.8349999785423279},{"id":"https://openalex.org/keywords/5p-deletion","display_name":"5p deletion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/13q-deletion","display_name":"13q deletion","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.9142253398895264},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.7270153760910034},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.5635855793952942},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5443607568740845},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.5350818037986755},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5021684169769287},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5001139640808105},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4785345494747162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.455615371465683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4112722873687744},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3639698028564453},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3593839406967163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34963834285736084},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.32235202193260193},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.30609846115112305},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.21229055523872375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1567865014076233},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0711280107498169}],"mesh":[{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/aog.0b013e3181bc6ab0","doi":"https://doi.org/10.1097/aog.0b013e3181bc6ab0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aog.0b013e3181bc6ab0","pdf_url":null,"source":{"id":"https://openalex.org/S139838620","display_name":"Obstetrics and Gynecology","issn_l":"0029-7844","issn":["0029-7844","1873-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics &amp; Gynecology","raw_type":"journal-article"},{"id":"pmid:20168112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20168112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics and gynecology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1540979859","https://openalex.org/W1969496555","https://openalex.org/W1991157854","https://openalex.org/W1999674531","https://openalex.org/W2000971189","https://openalex.org/W2002969945","https://openalex.org/W2016492861","https://openalex.org/W2026299153","https://openalex.org/W2032110921","https://openalex.org/W2045317645","https://openalex.org/W2062965527","https://openalex.org/W2063222008","https://openalex.org/W2063318299","https://openalex.org/W2108637300","https://openalex.org/W2129601019","https://openalex.org/W2140272492","https://openalex.org/W2155677754","https://openalex.org/W2287487613","https://openalex.org/W6634944916"],"related_works":["https://openalex.org/W3119942913","https://openalex.org/W2059207418","https://openalex.org/W2166018182","https://openalex.org/W2418764854","https://openalex.org/W2029158880","https://openalex.org/W2074390221","https://openalex.org/W2127645575","https://openalex.org/W2406603498","https://openalex.org/W1801008707","https://openalex.org/W1963591795"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"estimate":[2],"genomic":[3,20,62,148,216],"copy":[4,91,109,117,158,201,221],"number":[5,79,92,110,118,159,202,222],"changes":[6,80,119,160,210,223],"in":[7,81,103,122,139,152,163,173,183,224],"fetal":[8,55,69,82,123],"loss":[9,34],"between":[10,35],"10":[11],"and":[12,57,171,188,193,243],"20":[13],"weeks":[14,37],"of":[15,28,38,89,141,144,154,226,241,251],"gestation":[16,39],"using":[17,71,98,129,167,177],"array":[18,76,102,207],"comparative":[19,61,147,215],"hybridization.":[21],"METHODS:":[22],"This":[23],"was":[24,52,64,96,127,136,150,232],"a":[25,72,130],"prospective":[26],"series":[27],"35":[29,142],"women":[30],"who":[31],"experienced":[32],"pregnancy":[33,254],"10-20":[36],"with":[40,198],"either":[41],"normal":[42,233],"karyotype":[43],"(n=9)":[44],"or":[45,234],"no":[46],"conventional":[47],"cytogenetic":[48,230],"testing":[49,231],"(n=26).":[50],"DNA":[51,67,95,135,242],"isolated":[53,138],"from":[54,68,185],"tissue":[56,70,83],"parental":[58],"blood.":[59],"Array":[60,146,214],"hybridization":[63,149,217],"performed":[65,128,151],"on":[66,190],"whole":[73],"genome":[74],"BAC":[75,101],"chip.":[77,180],"Copy":[78],"were":[84,120,161],"then":[85],"compared":[86],"against":[87],"databases":[88],"benign":[90],"changes.":[93,111],"Parental":[94],"analyzed":[97],"the":[99,168,178,196,204],"same":[100],"cases":[104,113,166,176,197,227,250],"that":[105],"contained":[106],"suspected":[107],"pathogenic":[108],"In":[112,195],"where":[114,228],"de":[115,199,219],"novo":[116,157,200,220],"detected":[121,162,208,218],"DNA,":[124],"further":[125],"characterization":[126],"244K":[131],"oligonucleotide":[132],"microarray.":[133],"RESULTS:":[134],"successfully":[137],"30":[140],"(86%)":[143],"cases.":[145],"all":[153],"these.":[155],"De":[156],"six":[164],"(20%)":[165],"Spectral":[169],"chip":[170],"confirmed":[172],"four":[174],"(13%)":[175],"Agilent":[179,206],"These":[181,237],"ranged":[182],"size":[184],"93-289":[186],"Kb":[187],"mapped":[189],"5p,":[191],"13q":[192],"Xq22.":[194],"changes,":[203],"higher-density":[205],"additional":[209],"(20-1,310":[211],"Kb).":[212],"CONCLUSION:":[213],"13%":[225],"routine":[229],"not":[235],"performed.":[236],"involved":[238],"large":[239],"regions":[240],"may":[244],"provide":[245],"novel":[246],"explanations":[247],"for":[248],"some":[249],"otherwise":[252],"unexplained":[253],"loss.":[255],"LEVEL":[256],"OF":[257],"EVIDENCE:":[258],"III.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
