{"id":"https://openalex.org/W2007684558","doi":"https://doi.org/10.1021/bi012173m","title":"Dimers to Doughnuts: Redox-Sensitive Oligomerization of 2-Cysteine Peroxiredoxins,","display_name":"Dimers to Doughnuts: Redox-Sensitive Oligomerization of 2-Cysteine Peroxiredoxins,","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2007684558","doi":"https://doi.org/10.1021/bi012173m","mag":"2007684558","pmid":"https://pubmed.ncbi.nlm.nih.gov/11969410"},"language":"en","primary_location":{"id":"doi:10.1021/bi012173m","doi":"https://doi.org/10.1021/bi012173m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi012173m","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055799923","display_name":"Zachary A. Wood","orcid":"https://orcid.org/0000-0002-7251-0822","observed_orcids":["https://orcid.org/0000-0002-7251-0822"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary A. Wood","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039556554","display_name":"Leslie B. Poole","orcid":"https://orcid.org/0000-0003-0334-7328","observed_orcids":["https://orcid.org/0000-0003-0334-7328"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie B. Poole","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132023","display_name":"Roy R. Hantgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy R. Hantgan","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041427467","display_name":"P. Andrew Karplus","orcid":"https://orcid.org/0000-0001-8725-6292","observed_orcids":["https://orcid.org/0000-0001-8725-6292"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. Andrew Karplus","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, and Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041427467"],"corresponding_institution_ids":["https://openalex.org/I131249849","https://openalex.org/I47251452"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.7171,"has_fulltext":false,"cited_by_count":340,"citation_normalized_percentile":{"value":0.97890082,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"41","issue":"17","first_page":"5493","last_page":"5504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ahpc","display_name":"AhpC","score":0.8899999856948853},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.7409999966621399},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.671999990940094},{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.597000002861023},{"id":"https://openalex.org/keywords/peroxidatic-cysteine","display_name":"peroxidatic cysteine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/catalytic-cycle","display_name":"catalytic cycle","score":0.7609999775886536},{"id":"https://openalex.org/keywords/peroxidase-activity","display_name":"peroxidase activity","score":0.4560000002384186},{"id":"https://openalex.org/keywords/signaling-pathway-regulation","display_name":"signaling regulation","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7834962606430054},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.6529159545898438},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5824534893035889},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.5815906524658203},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5144524574279785},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.458736777305603},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3803158402442932},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24004453420639038},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014461","descriptor_name":"Ultracentrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054464","descriptor_name":"Peroxiredoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi012173m","doi":"https://doi.org/10.1021/bi012173m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi012173m","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:11969410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11969410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1641640346","display_name":null,"funder_award_id":"RR-01646","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3735504048","display_name":null,"funder_award_id":"GM50389","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4366278463","display_name":"Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins","funder_award_id":"R01GM050389","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5242596989","display_name":"Macromolecular Diffraction Resource: MacCHESS","funder_award_id":"P41RR001646","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W597159688","https://openalex.org/W1483721839","https://openalex.org/W1484322088","https://openalex.org/W1520425329","https://openalex.org/W1588367297","https://openalex.org/W1969156185","https://openalex.org/W1985374711","https://openalex.org/W1985397824","https://openalex.org/W1986191025","https://openalex.org/W1995017064","https://openalex.org/W1999377438","https://openalex.org/W2003488835","https://openalex.org/W2023861386","https://openalex.org/W2027250972","https://openalex.org/W2028231353","https://openalex.org/W2060807817","https://openalex.org/W2080970400","https://openalex.org/W2083477289","https://openalex.org/W2117937845","https://openalex.org/W2118969929","https://openalex.org/W2121455793","https://openalex.org/W2128442209","https://openalex.org/W2141384867","https://openalex.org/W2159564294","https://openalex.org/W2475248728","https://openalex.org/W2907795934","https://openalex.org/W4236079951"],"related_works":["https://openalex.org/W7095905781","https://openalex.org/W3045782314","https://openalex.org/W2087369660","https://openalex.org/W4380674922","https://openalex.org/W2093992625","https://openalex.org/W2888222972","https://openalex.org/W2095145021","https://openalex.org/W2593446917","https://openalex.org/W4406853309","https://openalex.org/W1987018075"],"abstract_inverted_index":{"2-Cys":[0,71,192],"peroxiredoxins":[1],"(Prxs)":[2],"are":[3,27,44,194],"a":[4,32,69,113,121,197],"large":[5],"and":[6,23,43,65,78,130,147,167,187],"diverse":[7],"family":[8],"of":[9,41,68,108,179,190],"peroxidases":[10],"which,":[11],"in":[12,154],"addition":[13],"to":[14,46,119,149,170,200],"their":[15],"antioxidant":[16],"functions,":[17],"regulate":[18],"cell":[19],"signaling":[20,188],"pathways,":[21],"apoptosis,":[22],"differentiation.":[24],"These":[25],"enzymes":[26],"obligate":[28],"homodimers":[29],"(alpha(2)),":[30],"utilizing":[31],"unique":[33],"intermolecular":[34],"redox-active":[35],"disulfide":[36,134],"center":[37],"for":[38],"the":[39,62,93,138,144,151,155,177,185],"reduction":[40],"peroxides,":[42],"known":[45],"form":[47],"two":[48],"oligomeric":[49,85,171],"states:":[50],"individual":[51],"alpha(2)":[52],"dimers":[53],"or":[54],"doughnut-shaped":[55],"(alpha(2))(5)":[56],"decamers.":[57],"Here":[58],"we":[59,182],"characterize":[60],"both":[61],"oligomerization":[63,115,152],"properties":[64],"crystal":[66,100],"structure":[67,101],"bacterial":[70],"Prx,":[72],"Salmonella":[73],"typhimurium":[74],"AhpC.":[75],"Analytical":[76],"ultracentrifugation":[77],"dynamic":[79],"light":[80],"scattering":[81],"show":[82],"that":[83,123,184],"AhpC's":[84],"state":[86,172],"is":[87,173],"redox":[88],"linked,":[89],"with":[90,128,133],"oxidization":[91],"favoring":[92,137],"dimeric":[94,131],"state.":[95],"The":[96],"2.5":[97],"A":[98,159],"resolution":[99],"(R":[102],"=":[103,106],"18.5%,":[104],"R(free)":[105],"23.9%)":[107],"oxidized,":[109],"decameric":[110,129,157],"AhpC":[111],"reveals":[112],"metastable":[114],"intermediate,":[116],"allowing":[117],"us":[118],"identify":[120],"loop":[122],"adopts":[124],"distinct":[125],"conformations":[126],"associated":[127],"states,":[132],"bond":[135],"formation":[136],"latter.":[139],"This":[140],"molecular":[141],"switch":[142],"contains":[143],"peroxidatic":[145],"cysteine":[146],"acts":[148],"buttress":[150],"interface":[153],"reduced,":[156],"enzyme.":[158],"structurally":[160],"detailed":[161],"catalytic":[162],"cycle":[163],"incorporating":[164],"these":[165],"ideas":[166],"linking":[168],"activity":[169],"presented.":[174],"Finally,":[175],"on":[176],"basis":[178],"sequence":[180],"comparisons,":[181],"suggest":[183],"enzymatic":[186],"activities":[189],"all":[191],"Prxs":[193],"regulated":[195],"by":[196],"redox-sensitive":[198],"dimer":[199],"decamer":[201],"transition.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}