{"id":"https://openalex.org/W2007680267","doi":"https://doi.org/10.1098/rsta.2012.0368","title":"Light-triggered nitric oxide delivery to malignant sites and infection","display_name":"Light-triggered nitric oxide delivery to malignant sites and infection","publication_year":2013,"publication_date":"2013-06-17","ids":{"openalex":"https://openalex.org/W2007680267","doi":"https://doi.org/10.1098/rsta.2012.0368","mag":"2007680267","pmid":"https://pubmed.ncbi.nlm.nih.gov/23776301"},"language":"en","primary_location":{"id":"doi:10.1098/rsta.2012.0368","doi":"https://doi.org/10.1098/rsta.2012.0368","is_oa":false,"landing_page_url":"https://doi.org/10.1098/rsta.2012.0368","pdf_url":null,"source":{"id":"https://openalex.org/S99517592","display_name":"Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences","issn_l":"1364-503X","issn":["1364-503X","1471-2962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024470193","display_name":"Brandon J. Heilman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Heilman","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060131715","display_name":"Pradip K. Mascharak","orcid":"https://orcid.org/0000-0002-7044-944X","observed_orcids":["https://orcid.org/0000-0002-7044-944X"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradip K. Mascharak","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":null,"apc_paid":null,"fwci":0.7798,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.61378205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"371","issue":"1995","first_page":"20120368","last_page":"20120368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.259799987077713,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.259799987077713,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.17440000176429749,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.925000011920929},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5960000157356262},{"id":"https://openalex.org/keywords/infection-treatment","display_name":"infection treatment","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7379810810089111},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6991181969642639},{"id":"https://openalex.org/C2779851234","wikidata":"https://www.wikidata.org/wiki/Q50690","display_name":"Oxide","level":2,"score":0.4636126160621643},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.44027653336524963},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4361702799797058},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4260823130607605},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.41820862889289856},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3432185649871826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14181959629058838},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11100447177886963},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053769","descriptor_name":"Nanocapsules","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053769","descriptor_name":"Nanocapsules","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1098/rsta.2012.0368","doi":"https://doi.org/10.1098/rsta.2012.0368","is_oa":false,"landing_page_url":"https://doi.org/10.1098/rsta.2012.0368","pdf_url":null,"source":{"id":"https://openalex.org/S99517592","display_name":"Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences","issn_l":"1364-503X","issn":["1364-503X","1471-2962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences","raw_type":"journal-article"},{"id":"pmid:23776301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23776301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical transactions. Series A, Mathematical, physical, and engineering sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W29312260","https://openalex.org/W43833714","https://openalex.org/W105596918","https://openalex.org/W572500970","https://openalex.org/W1532078988","https://openalex.org/W1588529524","https://openalex.org/W1605564201","https://openalex.org/W1821918060","https://openalex.org/W1929009802","https://openalex.org/W1963801343","https://openalex.org/W1966849581","https://openalex.org/W1970128017","https://openalex.org/W1972755364","https://openalex.org/W1972858609","https://openalex.org/W1975213869","https://openalex.org/W1980458823","https://openalex.org/W1982201293","https://openalex.org/W1983140088","https://openalex.org/W1985691574","https://openalex.org/W1987524945","https://openalex.org/W1988283250","https://openalex.org/W1992718978","https://openalex.org/W2000753519","https://openalex.org/W2003184674","https://openalex.org/W2003662848","https://openalex.org/W2004641607","https://openalex.org/W2008932829","https://openalex.org/W2009716635","https://openalex.org/W2010807192","https://openalex.org/W2011131666","https://openalex.org/W2017857250","https://openalex.org/W2018112418","https://openalex.org/W2019111242","https://openalex.org/W2023275162","https://openalex.org/W2023572761","https://openalex.org/W2024559949","https://openalex.org/W2028093908","https://openalex.org/W2038804582","https://openalex.org/W2040956342","https://openalex.org/W2043065633","https://openalex.org/W2047963812","https://openalex.org/W2054180834","https://openalex.org/W2054614691","https://openalex.org/W2057724703","https://openalex.org/W2066515050","https://openalex.org/W2070235067","https://openalex.org/W2078974772","https://openalex.org/W2082279342","https://openalex.org/W2086971976","https://openalex.org/W2092145002","https://openalex.org/W2094889906","https://openalex.org/W2095188041","https://openalex.org/W2098652851","https://openalex.org/W2110285736","https://openalex.org/W2129956169","https://openalex.org/W2131902476","https://openalex.org/W2152118462","https://openalex.org/W2164224870","https://openalex.org/W2169182236","https://openalex.org/W2318519052","https://openalex.org/W2320134209","https://openalex.org/W2325287136","https://openalex.org/W2334679641"],"related_works":["https://openalex.org/W1982201293","https://openalex.org/W2563070271","https://openalex.org/W2078974772","https://openalex.org/W4404094567","https://openalex.org/W746306594","https://openalex.org/W2086971976","https://openalex.org/W4403736947","https://openalex.org/W4409667149","https://openalex.org/W2739130035","https://openalex.org/W2027402771"],"abstract_inverted_index":{"The":[0,99],"discovery":[1],"of":[2,22,35,68,70,75,86,123,129],"nitric":[3],"oxide":[4],"(NO)":[5],"as":[6,26,40],"a":[7,84],"signalling":[8],"molecule":[9],"in":[10,19,109,111,120,126],"various":[11,71],"physiological":[12],"and":[13,106],"pathological":[14],"pathways":[15],"has":[16,82],"spurred":[17],"research":[18],"the":[20,48,65,121],"design":[21],"exogenous":[23],"NO":[24,63,96,130,134],"donors":[25,131],"drugs.":[27],"In":[28],"recent":[29,124],"years,":[30],"metal":[31,55],"nitrosyls":[32,56,78],"(NO":[33],"complexes":[34],"metals)":[36],"have":[37,52,102],"been":[38],"investigated":[39],"NO-donating":[41],"agents.":[42],"Results":[43],"from":[44,58],"our":[45,117],"laboratory":[46],"during":[47],"past":[49],"few":[50],"years":[51],"demonstrated":[53],"that":[54,89,132],"derived":[57],"designed":[59],"ligands":[60],"can":[61,90],"deliver":[62,133],"under":[64],"total":[66],"control":[67],"light":[69],"frequencies.":[72],"Careful":[73],"incorporation":[74],"these":[76],"photoactive":[77],"into":[79],"polymer":[80],"matrices":[81],"afforded":[83],"set":[85],"nitrosyl-polymer":[87],"composites":[88],"be":[91],"used":[92],"to":[93],"make":[94],"such":[95],"delivery":[97],"site-specific.":[98],"composite":[100],"materials":[101],"shown":[103],"excellent":[104],"antineoplastic":[105],"antimicrobial":[107],"actions":[108],"several":[110],"vitro":[112],"experiments.":[113],"This":[114],"review":[115],"highlights":[116],"key":[118],"results":[119],"context":[122],"developments":[125],"this":[127],"area":[128],"on":[135],"demand.":[136]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}