{"id":"https://openalex.org/W2007679709","doi":"https://doi.org/10.1111/j.1442-2042.1998.tb00227.x","title":"Adoptive Immunotherapy of Patients with Metastatic Renal Cell Cancer Using Lymphokine\u2010Activated Killer Cells, lnterleukin\u20102 and Cyclophosphamide: Long\u2010Term Results","display_name":"Adoptive Immunotherapy of Patients with Metastatic Renal Cell Cancer Using Lymphokine\u2010Activated Killer Cells, lnterleukin\u20102 and Cyclophosphamide: Long\u2010Term Results","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2007679709","doi":"https://doi.org/10.1111/j.1442-2042.1998.tb00227.x","mag":"2007679709","pmid":"https://pubmed.ncbi.nlm.nih.gov/9535595"},"language":"en","primary_location":{"id":"doi:10.1111/j.1442-2042.1998.tb00227.x","doi":"https://doi.org/10.1111/j.1442-2042.1998.tb00227.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1442-2042.1998.tb00227.x","pdf_url":null,"source":{"id":"https://openalex.org/S134892809","display_name":"International Journal of Urology","issn_l":"0919-8172","issn":["0919-8172","1442-2042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104095489","display_name":"Yoshihiko Tomita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshihiko Tomita","raw_affiliation_strings":["Department of Urology, Niigata University School of Medicine, Japan","Department of Urology, Niigata University School of Medicine, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Japan","institution_ids":["https://openalex.org/I71395657"]},{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022474144","display_name":"Akiyoshi Katagiri","orcid":"https://orcid.org/0000-0001-8057-1177","observed_orcids":["https://orcid.org/0000-0001-8057-1177"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiyoshi Katagiri","raw_affiliation_strings":["Department of Urology, Niigata University School of Medicine, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103641236","display_name":"Kazuhide Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhide Saito","raw_affiliation_strings":["Department of Urology, Niigata University School of Medicine, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006227176","display_name":"Tomoyuki Imai","orcid":"https://orcid.org/0000-0001-6858-1145","observed_orcids":["https://orcid.org/0000-0001-6858-1145"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Imai","raw_affiliation_strings":["Department of Urology, Niigata University School of Medicine, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103473825","display_name":"Toshihiro Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Saito","raw_affiliation_strings":["Department of Urology, Niigata University School of Medicine, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108944892","display_name":"Toshiki Tanikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiki Tanikawa","raw_affiliation_strings":["Department of Urology, Niigata University School of Medicine, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077796460","display_name":"Masahiro Terunuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256033","display_name":"Nagaoka Chuo General hospital","ror":"https://ror.org/03pgfk695","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256033"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Terunuma","raw_affiliation_strings":["Department of Urology, Koseiren Nagaoka Chuo General Hospital, Nagaoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Koseiren Nagaoka Chuo General Hospital, Nagaoka, Japan","institution_ids":["https://openalex.org/I4405256033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109189577","display_name":"Tsutomu Nishiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256033","display_name":"Nagaoka Chuo General hospital","ror":"https://ror.org/03pgfk695","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256033"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Nishiyama","raw_affiliation_strings":["Department of Urology, Koseiren Nagaoka Chuo General Hospital, Nagaoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Koseiren Nagaoka Chuo General Hospital, Nagaoka, Japan","institution_ids":["https://openalex.org/I4405256033"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105302269","display_name":"Kota Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Takahashi","raw_affiliation_strings":["Department of Urology, Niigata University School of Medicine, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Niigata University School of Medicine, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104095489"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":0.7402,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72109413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"5","issue":"1","first_page":"16","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":1.0},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/long-term-treatment-outcomes","display_name":"long-term treatment outcomes","score":0.675000011920929},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5839999914169312},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9572570323944092},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6670513153076172},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.6289986371994019},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5608023405075073},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4804677367210388},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.46046018600463867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45666223764419556},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.423892080783844},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41462060809135437},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3715801239013672},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.33651649951934814},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2976844310760498},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.27360814809799194},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21717092394828796},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.1694764494895935},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013902","descriptor_name":"Radiography, Thoracic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015979","descriptor_name":"Killer Cells, Lymphokine-Activated","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015979","descriptor_name":"Killer Cells, Lymphokine-Activated","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1442-2042.1998.tb00227.x","doi":"https://doi.org/10.1111/j.1442-2042.1998.tb00227.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1442-2042.1998.tb00227.x","pdf_url":null,"source":{"id":"https://openalex.org/S134892809","display_name":"International Journal of Urology","issn_l":"0919-8172","issn":["0919-8172","1442-2042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Urology","raw_type":"journal-article"},{"id":"pmid:9535595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9535595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of urology : official journal of the Japanese Urological Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1582239924","https://openalex.org/W1858735933","https://openalex.org/W1904436785","https://openalex.org/W1939353013","https://openalex.org/W1975644265","https://openalex.org/W1981216931","https://openalex.org/W1993864184","https://openalex.org/W2031142145","https://openalex.org/W2053886777","https://openalex.org/W2060664132","https://openalex.org/W2149724818","https://openalex.org/W2315776209","https://openalex.org/W2322553446","https://openalex.org/W2326245275","https://openalex.org/W2395074856","https://openalex.org/W2398781454","https://openalex.org/W2412037637","https://openalex.org/W2417076109","https://openalex.org/W3022038294","https://openalex.org/W4255539467"],"related_works":["https://openalex.org/W2424007990","https://openalex.org/W2315776209","https://openalex.org/W239242535","https://openalex.org/W1949673766","https://openalex.org/W2085925464","https://openalex.org/W1858735933","https://openalex.org/W212446474","https://openalex.org/W1999186358","https://openalex.org/W387947995","https://openalex.org/W2016873998"],"abstract_inverted_index":{"BACKGROUND:":[0],"Initial":[1],"results":[2,36,52],"of":[3,37,53,69,108,152,163,223,265,302],"adoptive":[4,54],"immunotherapy":[5,55],"using":[6,56],"lymphokine-activated":[7],"killer":[8],"(LAK)":[9],"cells":[10],"and":[11,33,60,81,102,139,195,235,257],"interleukin-2":[12],"(IL-2)":[13],"appeared":[14],"to":[15,71,110,214,246],"offer":[16],"promise":[17],"for":[18,106,154,285],"treating":[19],"renal":[20],"cell":[21],"cancer":[22],"(RCC).":[23],"However,":[24],"lower":[25],"response":[26,128,274],"rates":[27],"were":[28,95,268],"seen":[29],"in":[30,135,160,192,206,290],"subsequent":[31],"trials,":[32],"the":[34,86,161,176,193,199,210,220,233,272],"long-term":[35,51,296],"this":[38,47],"treatment":[39],"method":[40],"have":[41],"not":[42,269],"been":[43],"fully":[44],"reported.":[45],"In":[46],"study,":[48],"we":[49],"examine":[50],"LAK":[57],"cells,":[58],"IL-2,":[59],"cyclophosphamide":[61],"(LAK/IL-2/CPM":[62],"therapy).":[63],"METHODS:":[64],"We":[65],"administered":[66],"10":[67],"courses":[68],"therapy":[70,101,267,282,289],"9":[72,258],"patients":[73,141,254],"with":[74,132,198,271],"advanced":[75],"RCC.":[76],"One":[77,146],"patient":[78,131,148,166,177,188,211],"had":[79,88],"liver":[80],"para-aortic":[82],"lymph":[83],"node":[84],"metastases;":[85],"others":[87],"only":[89],"lung":[90,162,194],"metastases.":[91],"The":[92,114,185,225,251],"clinical":[93],"effects":[94,264],"initially":[96],"evaluated":[97],"4":[98,276],"weeks":[99,277],"after":[100,219,260,278],"follow-up":[103],"was":[104,170,196],"continued":[105],"periods":[107],"43":[109,155],"76":[111],"months.":[112,156,184],"RESULTS:":[113],"4-week":[115],"evaluation":[116],"revealed":[117],"3":[118,122],"complete":[119],"responses":[120,124],"(CR),":[121],"partial":[123],"(PR),":[125,208],"1":[126,130],"minor":[127],"(MR),":[129],"no":[133],"change":[134],"disease":[136,143,153,168],"status":[137],"(NC),":[138],"2":[140,217,226,245,252,256],"whose":[142],"progressed":[144],"(PD).":[145],"CR":[147,165,187],"remained":[149],"apparently":[150],"free":[151],"After":[157],"tumors":[158,204,304],"recurred":[159],"another":[164],"further":[167],"progression":[169],"suppressed":[171],"by":[172],"IL-2":[173],"administration":[174],"until":[175],"died":[178,212,255],"from":[179],"other":[180],"causes":[181],"at":[182],"46":[183],"third":[186],"showed":[189],"tumor":[190],"recurrence":[191],"re-treated":[197],"same":[200],"LAK/CPM/IL-2":[201],"therapy.":[202,250,261,279,309],"Lung":[203],"decreased":[205],"size":[207],"but":[209],"due":[213],"brain":[215],"metastasis":[216],"months":[218,248,259],"second":[221],"round":[222],"treatment.":[224],"initial":[227],"PR":[228],"patients,":[229,237],"as":[230,232,287],"well":[231],"MR":[234],"NC":[236],"developed":[238],"regrowth":[239],"or":[240,305],"new":[241],"metastatic":[242],"lesions":[243],"within":[244],"15":[247],"following":[249],"PD":[253],"CONCLUSION:":[262],"Long-term":[263],"LAK/IL-2/CPM":[266,281],"correlated":[270],"maximal":[273],"observed":[275],"Although":[280],"appears":[283],"suitable":[284],"use":[286],"induction":[288],"RCC,":[291],"our":[292],"data":[293],"suggest":[294],"that":[295],"suppression":[297],"will":[298],"require":[299],"surgical":[300],"removal":[301],"remnant":[303],"more":[306],"intensive":[307],"maintenance":[308]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}