{"id":"https://openalex.org/W2007676852","doi":"https://doi.org/10.1016/j.jamcollsurg.2012.06.204","title":"Development of an siRNA delivery system targeting macrophage function in-vivo","display_name":"Development of an siRNA delivery system targeting macrophage function in-vivo","publication_year":2012,"publication_date":"2012-08-21","ids":{"openalex":"https://openalex.org/W2007676852","doi":"https://doi.org/10.1016/j.jamcollsurg.2012.06.204","mag":"2007676852"},"language":"en","primary_location":{"id":"doi:10.1016/j.jamcollsurg.2012.06.204","doi":"https://doi.org/10.1016/j.jamcollsurg.2012.06.204","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2012.06.204","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028013905","display_name":"Felix C. Blanco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felix C. Blanco","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028845676","display_name":"P. Srinivasan","orcid":"https://orcid.org/0000-0001-6286-8612","observed_orcids":["https://orcid.org/0000-0001-6286-8612"]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Srinivasan","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046211361","display_name":"Ryan M. Walk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan M. Walk","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101622948","display_name":"Jason A. Snyder","orcid":"https://orcid.org/0000-0002-3840-8138","observed_orcids":["https://orcid.org/0000-0002-3840-8138"]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Snyder","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025891234","display_name":"Mark A. Behlke","orcid":"https://orcid.org/0000-0002-4218-857X","observed_orcids":["https://orcid.org/0000-0002-4218-857X"]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Behlke","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002551319","display_name":"Aliasger K. Salem","orcid":"https://orcid.org/0000-0002-1923-6633","observed_orcids":["https://orcid.org/0000-0002-1923-6633"]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aliasger K. Salem","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059688755","display_name":"Stanislav Vukmanovi\u0107","orcid":"https://orcid.org/0000-0003-3547-8349","observed_orcids":["https://orcid.org/0000-0003-3547-8349"]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav Vukmanovic","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056405095","display_name":"Anthony David Sandler","orcid":"https://orcid.org/0000-0001-9440-2964","observed_orcids":["https://orcid.org/0000-0001-9440-2964"]},"institutions":[{"id":"https://openalex.org/I4405282473","display_name":"Sheikh Zayed Institute for Pediatric Surgical Innovation","ror":"https://ror.org/05ws19t64","country_code":"US","type":"facility","lineage":["https://openalex.org/I1336742384","https://openalex.org/I4405282473"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony D. Sandler","raw_affiliation_strings":["Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC","institution_ids":["https://openalex.org/I4405282473"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405282473"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.2566,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53011765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"215","issue":"3","first_page":"S74","last_page":"S74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9829999804496765},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7229999899864197},{"id":"https://openalex.org/keywords/in-vivo-gene-silencing","display_name":"in vivo gene silencing","score":0.7129999995231628},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7160000205039978},{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.6119999885559082},{"id":"https://openalex.org/keywords/sirna-therapeutics","display_name":"siRNA therapeutics","score":0.375}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.734943687915802},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4806634187698364},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2508755326271057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05654004216194153}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jamcollsurg.2012.06.204","doi":"https://doi.org/10.1016/j.jamcollsurg.2012.06.204","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2012.06.204","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096004362","https://openalex.org/W1984718506","https://openalex.org/W2803317394","https://openalex.org/W1604069033","https://openalex.org/W2072565564","https://openalex.org/W7098416432","https://openalex.org/W7034454879","https://openalex.org/W1999732094","https://openalex.org/W7100308959","https://openalex.org/W7116314024"],"abstract_inverted_index":{"Blanco,":[0],"Felix":[1],"C.":[2],"MD;":[3,10,14],"Srinivasan,":[4],"Priya":[5],"PhD;":[6,18,22,26],"Walk,":[7],"Ryan":[8],"M.":[9],"Snyder,":[11],"Jason":[12],"A.":[13],"Behlke,":[15],"Mark":[16],"MD,":[17,25,30],"Salem,":[19],"Aliasger":[20],"K.":[21],"Vukmanovic,":[23],"Stanislav":[24],"Sandler,":[27],"Anthony":[28],"D.":[29],"FACS":[31],"Author":[32],"Information":[33]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}