{"id":"https://openalex.org/W2007668363","doi":"https://doi.org/10.1016/j.jconrel.2014.11.006","title":"In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy","display_name":"In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy","publication_year":2014,"publication_date":"2014-11-10","ids":{"openalex":"https://openalex.org/W2007668363","doi":"https://doi.org/10.1016/j.jconrel.2014.11.006","mag":"2007668363","pmid":"https://pubmed.ncbi.nlm.nih.gov/25445696"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2014.11.006","doi":"https://doi.org/10.1016/j.jconrel.2014.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2014.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083891900","display_name":"Y. Karrout","orcid":"https://orcid.org/0000-0002-9037-8490","observed_orcids":["https://orcid.org/0000-0002-9037-8490"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Y. Karrout","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France. Electronic address: youness.karrout@univ-lille2.fr","INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France. Electronic address: youness.karrout@univ-lille2.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066769682","display_name":"Laurent Dubuquoy","orcid":"https://orcid.org/0000-0003-3596-5497","observed_orcids":["https://orcid.org/0000-0003-3596-5497"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Dubuquoy","raw_affiliation_strings":["INSERM U995, Digestive Inflammatory Diseases, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U995, Digestive Inflammatory Diseases, Lille, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071070119","display_name":"Catherine Piveteau","orcid":"https://orcid.org/0000-0002-3835-4619","observed_orcids":["https://orcid.org/0000-0002-3835-4619"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Piveteau","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U761, Biostructures and Drug Discovery, Lille, France; Institut Pasteur de Lille, Lille, France; PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","INSERM U761, Biostructures and Drug Discovery, Lille, France","Institut Pasteur de Lille, Lille, France","PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U761, Biostructures and Drug Discovery, Lille, France; Institut Pasteur de Lille, Lille, France; PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988"]},{"raw_affiliation_string":"INSERM U761, Biostructures and Drug Discovery, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Pasteur de Lille, Lille, France","institution_ids":["https://openalex.org/I2800921988"]},{"raw_affiliation_string":"PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","institution_ids":[]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032587323","display_name":"Florence Siepmann","orcid":"https://orcid.org/0000-0001-6337-0234","observed_orcids":["https://orcid.org/0000-0001-6337-0234"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Siepmann","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Moussa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Moussa","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014499755","display_name":"Daniel Wils","orcid":"https://orcid.org/0000-0003-1570-1929","observed_orcids":["https://orcid.org/0000-0003-1570-1929"]},"institutions":[{"id":"https://openalex.org/I177879584","display_name":"Roquette Fr\u00e8res (France)","ror":"https://ror.org/00bywv891","country_code":"FR","type":"company","lineage":["https://openalex.org/I177879584"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Wils","raw_affiliation_strings":["Roquette, Biology and Nutrition Department, Lestrem, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roquette, Biology and Nutrition Department, Lestrem, France","institution_ids":["https://openalex.org/I177879584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011199227","display_name":"Terence B. Beghyn","orcid":"https://orcid.org/0000-0001-6096-4475","observed_orcids":["https://orcid.org/0000-0001-6096-4475"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T. Beghyn","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U761, Biostructures and Drug Discovery, Lille, France; Institut Pasteur de Lille, Lille, France; PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","INSERM U761, Biostructures and Drug Discovery, Lille, France","Institut Pasteur de Lille, Lille, France","PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U761, Biostructures and Drug Discovery, Lille, France; Institut Pasteur de Lille, Lille, France; PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988"]},{"raw_affiliation_string":"INSERM U761, Biostructures and Drug Discovery, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Pasteur de Lille, Lille, France","institution_ids":["https://openalex.org/I2800921988"]},{"raw_affiliation_string":"PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","institution_ids":[]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024532376","display_name":"Christel Neut","orcid":"https://orcid.org/0000-0002-2036-6152","observed_orcids":["https://orcid.org/0000-0002-2036-6152"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Neut","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U995, Digestive Inflammatory Diseases, Lille, France","INSERM U995, Digestive Inflammatory Diseases, Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U995, Digestive Inflammatory Diseases, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U995, Digestive Inflammatory Diseases, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111954535","display_name":"Marie\u2010Pierre Flament","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M.-P. Flament","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089412589","display_name":"Laetitia Gu\u00e9rin\u2010Deremaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177879584","display_name":"Roquette Fr\u00e8res (France)","ror":"https://ror.org/00bywv891","country_code":"FR","type":"company","lineage":["https://openalex.org/I177879584"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Guerin-Deremaux","raw_affiliation_strings":["Roquette, Biology and Nutrition Department, Lestrem, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roquette, Biology and Nutrition Department, Lestrem, France","institution_ids":["https://openalex.org/I177879584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090350686","display_name":"Luc J. Dubreuil","orcid":"https://orcid.org/0000-0001-6814-8739","observed_orcids":["https://orcid.org/0000-0001-6814-8739"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Dubreuil","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U995, Digestive Inflammatory Diseases, Lille, France","INSERM U995, Digestive Inflammatory Diseases, Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U995, Digestive Inflammatory Diseases, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U995, Digestive Inflammatory Diseases, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082727963","display_name":"Benoit P. Deprez","orcid":"https://orcid.org/0000-0002-2777-4538","observed_orcids":["https://orcid.org/0000-0002-2777-4538"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Deprez","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U761, Biostructures and Drug Discovery, Lille, France; Institut Pasteur de Lille, Lille, France; PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","INSERM U761, Biostructures and Drug Discovery, Lille, France","Institut Pasteur de Lille, Lille, France","PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U761, Biostructures and Drug Discovery, Lille, France; Institut Pasteur de Lille, Lille, France; PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988"]},{"raw_affiliation_string":"INSERM U761, Biostructures and Drug Discovery, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Pasteur de Lille, Lille, France","institution_ids":["https://openalex.org/I2800921988"]},{"raw_affiliation_string":"PRIM(P\u00f4le de Recherche Interdisciplinaire sur le M\u00e9dicament), Lille, France","institution_ids":[]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073322732","display_name":"Pierre Desreumaux","orcid":"https://orcid.org/0000-0002-6127-5281","observed_orcids":["https://orcid.org/0000-0002-6127-5281"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Desreumaux","raw_affiliation_strings":["INSERM U995, Digestive Inflammatory Diseases, Lille, France; University of Lille, School of Medicine, Lille, France","INSERM U995, Digestive Inflammatory Diseases, Lille, France","University of Lille, School of Medicine, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U995, Digestive Inflammatory Diseases, Lille, France; University of Lille, School of Medicine, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U995, Digestive Inflammatory Diseases, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, School of Medicine, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074473640","display_name":"Juergen Siepmann","orcid":"https://orcid.org/0000-0001-9058-0579","observed_orcids":["https://orcid.org/0000-0001-9058-0579"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J. Siepmann","raw_affiliation_strings":["University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France. Electronic address: juergen.siepmann@univ-lille2.fr","INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","University of Lille, College of Pharmacy, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France; INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France. Electronic address: juergen.siepmann@univ-lille2.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"]},{"raw_affiliation_string":"INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"University of Lille, College of Pharmacy, Lille, France","institution_ids":["https://openalex.org/I2279609970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074473640","https://openalex.org/A5083891900"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":1.8441,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.80452022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"197","issue":null,"first_page":"121","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-specific-drug-delivery","display_name":"colon-targeted drug delivery","score":0.9350000023841858},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tnbs-induced-colitis","display_name":"TNBS-induced colitis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ethylcellulose","display_name":"ethyl cellulose","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ppargamma-activation","display_name":"PPAR\u03b3 activation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hmgcs2","display_name":"HMGCS2","score":0.9020000100135803},{"id":"https://openalex.org/keywords/n-acetyl-5-aminosalicylic-acid","display_name":"N-acetyl-5-aminosalicylic acid","score":0.8880000114440918},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.4869999885559082},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.5419999957084656},{"id":"https://openalex.org/keywords/extrusion-spheronization","display_name":"extrusion-spheronization","score":0.6800000071525574},{"id":"https://openalex.org/keywords/pentasa","display_name":"Pentasa","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7857886552810669},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7221821546554565},{"id":"https://openalex.org/C2780584874","wikidata":"https://www.wikidata.org/wiki/Q575866","display_name":"Pellets","level":2,"score":0.7012969255447388},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5661115050315857},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5176963806152344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46308761835098267},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4515780210494995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34860876202583313},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32439589500427246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27586275339126587},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17621594667434692},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1703566014766693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13512223958969116},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06701985001564026},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003912","descriptor_name":"Dextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006904","descriptor_name":"Hydroxymethylglutaryl-CoA Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013213","descriptor_name":"Starch","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014302","descriptor_name":"Trinitrobenzenesulfonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jconrel.2014.11.006","doi":"https://doi.org/10.1016/j.jconrel.2014.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2014.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:25445696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25445696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1648036481","https://openalex.org/W1735043565","https://openalex.org/W1915167663","https://openalex.org/W1972616704","https://openalex.org/W1979363781","https://openalex.org/W1987166489","https://openalex.org/W1999594466","https://openalex.org/W2005774144","https://openalex.org/W2006554458","https://openalex.org/W2007674178","https://openalex.org/W2018841280","https://openalex.org/W2034902318","https://openalex.org/W2040756737","https://openalex.org/W2049670444","https://openalex.org/W2058005106","https://openalex.org/W2060608498","https://openalex.org/W2062854941","https://openalex.org/W2063238954","https://openalex.org/W2068245036","https://openalex.org/W2070535546","https://openalex.org/W2081219778","https://openalex.org/W2085637472","https://openalex.org/W2090064793","https://openalex.org/W2100303227","https://openalex.org/W2136054045","https://openalex.org/W2137537116","https://openalex.org/W2148649000","https://openalex.org/W2149250017","https://openalex.org/W2157393124","https://openalex.org/W2162098634","https://openalex.org/W2163742371"],"related_works":["https://openalex.org/W2034902318","https://openalex.org/W4391655777","https://openalex.org/W2041692703","https://openalex.org/W4367298323","https://openalex.org/W3128599295","https://openalex.org/W1978825473","https://openalex.org/W370248260","https://openalex.org/W3126380452","https://openalex.org/W2063238954","https://openalex.org/W1972616704"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}