{"id":"https://openalex.org/W2007662619","doi":"https://doi.org/10.1002/pbc.22844","title":"Steroid therapy may be effective in augmenting hemoglobin levels during hemolytic crises in children with hereditary spherocytosis","display_name":"Steroid therapy may be effective in augmenting hemoglobin levels during hemolytic crises in children with hereditary spherocytosis","publication_year":2011,"publication_date":"2011-04-07","ids":{"openalex":"https://openalex.org/W2007662619","doi":"https://doi.org/10.1002/pbc.22844","mag":"2007662619","pmid":"https://pubmed.ncbi.nlm.nih.gov/21480468"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.22844","doi":"https://doi.org/10.1002/pbc.22844","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.22844","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110027109","display_name":"Ami Ballin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800717019","display_name":"Wolfson Medical Center","ror":"https://ror.org/04ayype77","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800717019"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ami Ballin","raw_affiliation_strings":["Department of Pediatrics, Edith Wolfson Medical Center, Holon, Israel. ballin@wolfson.health.gov.il","Department of Pediatrics, Edith Wolfson Medical Center, Holon, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Edith Wolfson Medical Center, Holon, Israel. ballin@wolfson.health.gov.il","institution_ids":["https://openalex.org/I2800717019"]},{"raw_affiliation_string":"Department of Pediatrics, Edith Wolfson Medical Center, Holon, Israel","institution_ids":["https://openalex.org/I2800717019"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056005376","display_name":"Orith Waisbourd\u2010Zinman","orcid":"https://orcid.org/0000-0003-0410-175X","observed_orcids":["https://orcid.org/0000-0003-0410-175X"]},"institutions":[{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Orit Waisbourd\u2010Zinman","raw_affiliation_strings":["Department of Pediatrics A, Schneider Children's Medical Center of Israel, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics A, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090861843","display_name":"Hitam Saab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113309","display_name":"Bnai Zion Medical Center","ror":"https://ror.org/01yvj7247","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210113309"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hitam Saab","raw_affiliation_strings":["Department of Ophthalmology, Bnei-Zion Hospital, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Bnei-Zion Hospital, Haifa, Israel","institution_ids":["https://openalex.org/I4210113309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076491464","display_name":"Joanne Yacobovich","orcid":"https://orcid.org/0000-0003-3763-5694","observed_orcids":["https://orcid.org/0000-0003-3763-5694"]},"institutions":[{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Joanne Yacobovich","raw_affiliation_strings":["Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113565344","display_name":"M. Zoldan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Meirah Zoldan","raw_affiliation_strings":["Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031221166","display_name":"Shlomit Barzilai\u2010Birenbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shlomit Barzilai\u2010Birenbaum","raw_affiliation_strings":["Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043164298","display_name":"Isaac Yaniv","orcid":"https://orcid.org/0009-0005-1063-5872","observed_orcids":["https://orcid.org/0009-0005-1063-5872"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Isaac Yaniv","raw_affiliation_strings":["Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090093053","display_name":"Hannah Tamary","orcid":"https://orcid.org/0000-0003-4745-3448","observed_orcids":["https://orcid.org/0000-0003-4745-3448"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hannah Tamary","raw_affiliation_strings":["Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110027109"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800717019"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":0.2169,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.59076859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"57","issue":"2","first_page":"303","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.31349998712539673,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-spherocytosis","display_name":"hereditary spherocytosis","score":1.0},{"id":"https://openalex.org/keywords/hemolytic-crisis","display_name":"hemolytic crisis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7749999761581421},{"id":"https://openalex.org/keywords/red-blood-cell-transfusion","display_name":"red blood cell transfusion","score":0.7839999794960022},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9239869117736816},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.7421603202819824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5408097505569458},{"id":"https://openalex.org/C2776952295","wikidata":"https://www.wikidata.org/wiki/Q541244","display_name":"Hereditary spherocytosis","level":2,"score":0.5379961133003235},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.5040425658226013},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.47272366285324097},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.46626386046409607},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4530772864818573},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35057011246681213}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009996","descriptor_name":"Osmotic Fragility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013103","descriptor_name":"Spherocytosis, Hereditary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017707","descriptor_name":"Erythrocyte Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pbc.22844","doi":"https://doi.org/10.1002/pbc.22844","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.22844","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},{"id":"pmid:21480468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21480468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1521884758","https://openalex.org/W1976414689","https://openalex.org/W2001972906","https://openalex.org/W2034091096","https://openalex.org/W2046089995","https://openalex.org/W2078872208","https://openalex.org/W2411491448","https://openalex.org/W4299792003"],"related_works":["https://openalex.org/W1976414689","https://openalex.org/W2468398825","https://openalex.org/W3030777386","https://openalex.org/W2006676263","https://openalex.org/W2435065718","https://openalex.org/W2418686924","https://openalex.org/W7160188868","https://openalex.org/W2070785056","https://openalex.org/W6986726970","https://openalex.org/W7099302700"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,17,42,138,175],"course":[2,30],"of":[3,19,27,31,44,60,90,144,149,173,183],"hereditary":[4],"spherocytosis":[5],"(HS)":[6],"may":[7,213],"be":[8,214],"subject":[9],"to":[10,23,52,155],"hemolytic":[11,39,61,147,181,208,221],"episodes,":[12],"sometimes":[13],"requiring":[14],"blood":[15,74],"transfusion.":[16,238],"aim":[18],"this":[20],"study":[21,116,139],"was":[22,63,85,135,159,192],"evaluate":[24],"the":[25,98,105,115],"efficacy":[26],"a":[28,142,163,187,233],"short":[29,169],"steroid":[32],"therapy":[33,191,198,212],"in":[34,94,132,199,206,216,223,232],"elevating":[35],"hemoglobin":[36,95,130,201,218],"levels":[37,219],"during":[38,114,220],"crisis.":[40],"PROCEDURE:":[41],"files":[43],"all":[45],"patients":[46,70,107,178,224],"followed":[47],"for":[48,236],"HS":[49,109,227],"from":[50,97],"1968":[51],"2009":[53],"at":[54,91],"our":[55,112],"hospital":[56,113],"were":[57,80,119],"reviewed.":[58],"Outcome":[59],"crises":[62,148,222],"compared":[64],"between":[65],"steroid-treated":[66,146],"and":[67,123,228],"untreated":[68,177],"patients;":[69],"given":[71],"packed":[72],"red":[73],"cell":[75],"transfusion(s)":[76],"or":[77,168],"erythropoietin":[78],"treatment":[79],"excluded.":[81],"A":[82],"good":[83,188],"outcome":[84],"defined":[86],"as":[87],"an":[88],"increase":[89],"least":[92],"20%":[93],"level":[96,131,202],"nadir":[99,129],"within":[100],"1":[101],"week.":[102],"RESULTS:":[103],"Of":[104],"118":[106],"with":[108,121,162,225],"who":[110],"attended":[111],"period,":[117],"20":[118],"treated":[120],"steroids":[122],"9":[124],"received":[125],"no":[126,197],"treatment.":[127,156,174],"Mean":[128],"both":[133],"groups":[134],"6.9":[136],"g/dl.":[137],"group":[140],"had":[141,179,186],"total":[143],"50":[145],"which":[150,184],"37":[151],"(74%)":[152],"responded":[153],"favorably":[154],"Treatment":[157],"failure":[158],"significantly":[160,193],"associated":[161],"low":[164],"dose":[165],"(<1":[166,171],"mg/kg/day)":[167],"duration":[170],"week)":[172],"nine":[176],"16":[180],"crises,":[182],"25%":[185],"outcome.":[189],"Steroid":[190,211],"more":[194],"effective":[195,215],"than":[196],"increasing":[200],"(P":[203],"=":[204],"0.015)":[205],"these":[207],"crises.":[209],"CONCLUSION:":[210],"augmenting":[217],"moderate":[226],"eventually":[229],"will":[230],"result":[231],"reduced":[234],"need":[235],"RBC":[237]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
