{"id":"https://openalex.org/W2007657331","doi":"https://doi.org/10.1055/s-2001-19137","title":"Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus","display_name":"Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2007657331","doi":"https://doi.org/10.1055/s-2001-19137","mag":"2007657331","pmid":"https://pubmed.ncbi.nlm.nih.gov/11753762"},"language":"en","primary_location":{"id":"doi:10.1055/s-2001-19137","doi":"https://doi.org/10.1055/s-2001-19137","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-2001-19137","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-19137.pdf","source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-19137.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105886727","display_name":"Sara Serafina S\u00e1nchez","orcid":"https://orcid.org/0000-0001-6698-3095","observed_orcids":["https://orcid.org/0000-0001-6698-3095"]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"S. S. S\u00e1nchez","raw_affiliation_strings":["Departamento de Biolog\u00eda del Desarrollo, INSIBIO (CONICET-UNT), Chacabuco 461, 4000-San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina. ssanch@unt.edu.ar","Departamento de Biolog\u00eda del Desarrollo, INSIBIO (CONICET-UNT), Chacabuco 461, 4000-San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO (CONICET-UNT), Chacabuco 461, 4000-San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina. ssanch@unt.edu.ar","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO (CONICET-UNT), Chacabuco 461, 4000-San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017666148","display_name":"Manuel Javier Aybar","orcid":"https://orcid.org/0000-0002-7187-6435","observed_orcids":["https://orcid.org/0000-0002-7187-6435"]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M. J. Aybar","raw_affiliation_strings":["Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210091080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063301247","display_name":"Mar\u00eda S. Velarde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M. S. Velarde","raw_affiliation_strings":["Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210091080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110008192","display_name":"Mar\u00eda Mercedes Prado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M. M. Prado","raw_affiliation_strings":["Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210091080"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109071396","display_name":"Teresita Carrizo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"T. Carrizo","raw_affiliation_strings":["Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00e1tedra de Pr\u00e1ctica Hospitalaria (M.S.V., M.M.P, T.C.), Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Tucum\u00e1n, Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo, INSIBIO, CONICET-UNT; and C\u00b5tedra de Pr\u00b5ctica Hospitalaria","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210091080"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"12","first_page":"748","last_page":"751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":1.0},{"id":"https://openalex.org/keywords/plasma-endothelin-levels","display_name":"plasma endothelin levels","score":0.7829999923706055},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.800000011920929},{"id":"https://openalex.org/keywords/diabetic-vascular-complications","display_name":"diabetic vascular complications","score":0.824999988079071},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.6010000109672546},{"id":"https://openalex.org/keywords/microvascular-disease","display_name":"microangiopathy","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.83705735206604},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.8086140155792236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7540955543518066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6639422178268433},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.567777693271637},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5603635311126709},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.555080771446228},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.4331130385398865},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0384981632232666}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-2001-19137","doi":"https://doi.org/10.1055/s-2001-19137","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-2001-19137","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-19137.pdf","source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},{"id":"pmid:11753762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11753762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/97944","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/97944","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1055/s-2001-19137","doi":"https://doi.org/10.1055/s-2001-19137","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-2001-19137","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-19137.pdf","source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007657331.pdf","grobid_xml":"https://content.openalex.org/works/W2007657331.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2769264260"],"related_works":["https://openalex.org/W2121704189","https://openalex.org/W1984659199","https://openalex.org/W2372547878","https://openalex.org/W2084060397","https://openalex.org/W2320339117","https://openalex.org/W2083805868","https://openalex.org/W1965821367","https://openalex.org/W2023521562","https://openalex.org/W7097842021","https://openalex.org/W2146382099"],"abstract_inverted_index":{"Introduction":[0],"The":[1,313],"pathogenesis":[2,265],"of":[3,7,19,42,193,220,249,266,286,290,301,315],"the":[4,15,51,191,218,242,247,264,287,298,316,323],"vascular":[5,251],"complications":[6,233],"diabetes":[8,144,181,196,333,350],"is":[9,261],"controversial,":[10],"micro-":[11],"and":[12,21,127,161,177,187,330,351],"macroangiopathy":[13],"being":[14,270],"most":[16],"common":[17],"cause":[18],"morbidity":[20],"mortality":[22,276],"in":[23,32,40,84,96,140,173,204,246,263,274,284,308,339,344,364],"diabetic":[24,33,226,250,311,365],"patients.":[25,312,366],"Endothelial":[26],"cell":[27,91],"damage,":[28],"thought":[29],"to":[30,80,239,321,353,360],"occur":[31],"patients,":[34],"may":[35],"be":[36,81],"an":[37],"important":[38],"factor":[39,245,273],"development":[41,248],"angiopathy":[43],"[":[44,47,72,100,103,106,112,118,121,124,129,146,149,152,158,165,209,234,277,280],"1":[45],"]":[46,102,105,120,123,148,151,160,167,279],"2":[48,184,195,310,332,349],"].":[49,74,131,154,211,282],"For":[50],"last":[52],"few":[53,293],"years,":[54],"considerable":[55],"evidence":[56],"has":[57],"connected":[58],"endothelin-1":[59],"(ET-1),":[60],"a":[61,271],"strong":[62],"endothelial-derived":[63],"vasoconstrictor":[64],"mitogenic":[65],"peptide,":[66],"with":[67,86,89,98,179,186,206,297,342,346],"various":[68],"cardiovascular":[69,232,275],"disease":[70,117],"states":[71],"3":[73],"Plasma":[75],"ET-1":[76,135,171,328,337,356],"concentrations":[77,338],"were":[78,319,358],"found":[79],"abnormally":[82],"high":[83,258],"patients":[85,141,178,205,345],"conditions":[87],"associated":[88],"endothelial":[90,306],"injury,":[92],"as":[93,95,241],"well":[94],"those":[97,343],"hypertension":[99],"4":[101],"5":[104],"6":[107],"],":[108,114,126,236],"congestive":[109],"heart":[110,268],"failure":[111],"7":[113],"coronary":[115,267],"artery":[116],"8":[119],"9":[122],"10":[125],"uremia":[128],"11":[130],"Contradictory":[132],"findings":[133],"regarding":[134],"levels":[136,172,200,329,357],"have":[137,215,295],"been":[138],"reported":[139],"suffering":[142],"from":[143],"mellitus":[145,182],"12":[147],"13":[150],"14":[153,159],"Bertello":[155],"et":[156,163],"al.":[157,164],"Kanno":[162],"15":[166],"described":[168],"similar":[169],"plasma":[170,198,327,336],"both":[174],"healthy":[175,340],"controls":[176],"non-insulin-dependent":[180],"(Type":[183],"diabetes)":[185],"without":[188],"complications.":[189,252],"However,":[190,283],"influence":[192,300],"Type":[194,309,331,348],"on":[197,305],"endothelin":[199],"was":[201],"definitely":[202],"established":[203],"advanced":[207],"atherosclerosis":[208],"16":[210],"Recent":[212],"clinical":[213],"studies":[214,294],"indicated":[216],"that":[217,257],"normalization":[219],"glycemic":[221],"control":[222,304,363],"cannot":[223],"only":[224],"prevent":[225],"microangiopathies,":[227],"but":[228],"might":[229],"possibly":[230],"avert":[231],"17":[235],"thus":[237],"pointing":[238],"hyperglycemia":[240],"major":[243],"causal":[244],"Moreover,":[253],"there":[254],"are":[255],"indications":[256],"blood":[259],"glucose":[260,302,361],"involved":[262],"disease,":[269],"significant":[272,288],"18":[278],"19":[281],"spite":[285],"effects":[289],"hyperglycemia,":[291],"very":[292],"dealt":[296],"possible":[299,324],"metabolic":[303,362],"reactivity":[307],"aims":[314],"present":[317],"paper":[318],"a)":[320],"establish":[322],"relationship":[325],"between":[326],"by":[334],"comparing":[335],"subjects":[341],"uncomplicated":[347],"b)":[352],"determine":[354],"whether":[355],"related":[359]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}