{"id":"https://openalex.org/W2007656636","doi":"https://doi.org/10.2174/1568005310202020119","title":"Targeting the AMP-Activated Protein Kinase for the Treatment of Type 2 Diabetes","display_name":"Targeting the AMP-Activated Protein Kinase for the Treatment of Type 2 Diabetes","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2007656636","doi":"https://doi.org/10.2174/1568005310202020119","mag":"2007656636","pmid":"https://pubmed.ncbi.nlm.nih.gov/12476786"},"language":"en","primary_location":{"id":"doi:10.2174/1568005310202020119","doi":"https://doi.org/10.2174/1568005310202020119","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568005310202020119","pdf_url":null,"source":{"id":"https://openalex.org/S118480599","display_name":"Current Drug Targets - Immune Endocrine & Metabolic Disorders","issn_l":"1568-0088","issn":["1568-0088","1875-5917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Target - Immune, Endocrine &amp; Metabolic Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034471398","display_name":"Nicolas Musi","orcid":"https://orcid.org/0000-0003-4242-2888","observed_orcids":["https://orcid.org/0000-0003-4242-2888","https://orcid.org/0009-0004-4063-9041"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Musi","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Womens's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Womens's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039947894","display_name":"Laurie J. Goodyear","orcid":"https://orcid.org/0000-0002-6299-2928","observed_orcids":["https://orcid.org/0000-0002-6299-2928"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie Goodyear","raw_affiliation_strings":["Research Division, JoslinDiabetes Center, One Joslin Place, Boston, MA 02215,,India","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, JoslinDiabetes Center, One Joslin Place, Boston, MA 02215,,India","institution_ids":["https://openalex.org/I1293231726"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.844,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.84409055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"2","first_page":"119","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ampk-activators","display_name":"AMPK activators","score":0.7900000214576721},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.777999997138977},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/glucose-production","display_name":"glucose production","score":0.6119999885559082},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8939999938011169},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.8949999809265137},{"id":"https://openalex.org/keywords/energy-sensing","display_name":"energy sensing","score":0.5809999704360962},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.9574167728424072},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.7984977960586548},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6953980326652527},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6462550759315491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6283307671546936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5236710906028748},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.50579833984375},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4721004366874695},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.4406794011592865},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.43089720606803894},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4113214612007141},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.40437445044517517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31403863430023193},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3091389834880829},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.251812607049942}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/1568005310202020119","doi":"https://doi.org/10.2174/1568005310202020119","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568005310202020119","pdf_url":null,"source":{"id":"https://openalex.org/S118480599","display_name":"Current Drug Targets - Immune Endocrine & Metabolic Disorders","issn_l":"1568-0088","issn":["1568-0088","1875-5917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Target - Immune, Endocrine &amp; Metabolic Disorders","raw_type":"journal-article"},{"id":"doi:10.2174/1568008023340730","doi":"https://doi.org/10.2174/1568008023340730","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568008023340730","pdf_url":null,"source":{"id":"https://openalex.org/S118480599","display_name":"Current Drug Targets - Immune Endocrine & Metabolic Disorders","issn_l":"1568-0088","issn":["1568-0088","1875-5917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Targets - Immune, Endocrine &amp; Metabolic Disorders","raw_type":"journal-article"},{"id":"pmid:12476786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12476786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug targets. Immune, endocrine and metabolic disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1117239162","display_name":null,"funder_award_id":"AR45670","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2302556178","display_name":"Exercise Regulation of Glucose Metabolism in Skeletal Muscle","funder_award_id":"R01AR045670","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108156859","https://openalex.org/W2368325397","https://openalex.org/W2007415406","https://openalex.org/W2084026255","https://openalex.org/W2129346318","https://openalex.org/W4297986134","https://openalex.org/W2023382073","https://openalex.org/W2013149813","https://openalex.org/W1974550672","https://openalex.org/W2112133879"],"abstract_inverted_index":{"The":[0],"AMP-activated":[1],"protein":[2],"kinase":[3],"(AMPK)":[4],"is":[5,10],"an":[6,50,70],"energy-sensing":[7],"enzyme":[8],"that":[9,92],"activated":[11],"in":[12,52,83,114],"response":[13],"to":[14,32,116,130],"conditions":[15],"of":[16,29,41,58,77,86,95,123,127],"cellular":[17],"stress":[18],"such":[19],"as":[20],"muscle":[21],"contraction":[22],"and":[23,39,56,65,106],"hypoxia.":[24],"In":[25,44],"skeletal":[26],"muscle,":[27],"activation":[28,48,94,126],"AMPK":[30,47,69,96,128],"leads":[31],"increased":[33],"glucose":[34,59,64,105],"uptake,":[35],"enhanced":[36],"insulin":[37,107],"sensitivity":[38],"oxidation":[40,55],"fatty":[42,53],"acids.":[43],"the":[45,75,98,121],"liver,":[46],"causes":[49],"increase":[51],"acid":[54],"inhibition":[57],"production.":[60],"These":[61],"effects":[62],"on":[63],"fat":[66],"metabolism":[67],"make":[68],"important":[71],"pharmacological":[72,93,125],"target":[73],"for":[74],"treatment":[76],"type":[78,87],"2":[79,88],"diabetes.":[80],"Studies":[81],"done":[82],"animal":[84],"models":[85],"diabetes":[89],"have":[90],"shown":[91],"with":[97],"compound":[99],"5-aminoimidazole-4-carboxamide":[100],"ribonucleoside":[101],"(AICAR)":[102],"decreases":[103],"blood":[104],"concentrations.":[108],"While":[109],"strong":[110],"efforts":[111],"are":[112],"underway":[113],"order":[115],"identify":[117],"novel":[118],"AMPK-activating":[119],"compounds,":[120],"safety":[122],"chronic":[124],"remains":[129],"be":[131],"determined.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
