{"id":"https://openalex.org/W2007644094","doi":"https://doi.org/10.1248/bpb.26.1661","title":"Cardiovascular Assessment of ER-118585, a Selective Phosphodiesterase 5 Inhibitor","display_name":"Cardiovascular Assessment of ER-118585, a Selective Phosphodiesterase 5 Inhibitor","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2007644094","doi":"https://doi.org/10.1248/bpb.26.1661","mag":"2007644094","pmid":"https://pubmed.ncbi.nlm.nih.gov/14646167"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.26.1661","doi":"https://doi.org/10.1248/bpb.26.1661","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.26.1661","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/26/12/26_12_1661/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb/26/12/26_12_1661/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103070488","display_name":"Hiroshi Mizuno","orcid":"https://orcid.org/0000-0002-0975-1076","observed_orcids":["https://orcid.org/0000-0002-0975-1076"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Mizuno","raw_affiliation_strings":["Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113772824","display_name":"Hideyuki Adachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Adachi","raw_affiliation_strings":["Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059199772","display_name":"Junko Kimura","orcid":"https://orcid.org/0000-0003-2053-3683","observed_orcids":["https://orcid.org/0000-0003-2053-3683"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Kimura","raw_affiliation_strings":["Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109280413","display_name":"Yoshio Sawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Sawa","raw_affiliation_strings":["Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022240981","display_name":"Motoharu Kakiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoharu Kakiki","raw_affiliation_strings":["Drug Metabolism and Pharmacokinetics Research, Eisai Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics Research, Eisai Co., Ltd","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109215365","display_name":"Kate Lansdell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28927889","display_name":"IQVIA (United Kingdom)","ror":"https://ror.org/040g76k92","country_code":"GB","type":"company","lineage":["https://openalex.org/I28927889","https://openalex.org/I4210108991"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate Lansdell","raw_affiliation_strings":["Quintiles Preclinical Services, Quintiles, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quintiles Preclinical Services, Quintiles, Ltd","institution_ids":["https://openalex.org/I28927889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113947688","display_name":"Mamoru Sait\u014d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Saito","raw_affiliation_strings":["Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research, Drug Safety Research Laboratories, Eisai Co., Ltd","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086489874","display_name":"William Kerns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William David Kerns","raw_affiliation_strings":["Pharma Consulting, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Consulting, Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6597,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75776565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"26","issue":"12","first_page":"1661","last_page":"1667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/herg-channel","display_name":"hERG","score":0.6299999952316284},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/action-potential-duration","display_name":"action potential duration","score":0.8169999718666077},{"id":"https://openalex.org/keywords/drug-induced-arrhythmia","display_name":"drug-induced arrhythmia","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.4959999918937683},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.5659999847412109},{"id":"https://openalex.org/keywords/guinea-pig-papillary-muscle","display_name":"guinea pig papillary muscle","score":0.7609999775886536},{"id":"https://openalex.org/keywords/atrial-pacing","display_name":"atrial pacing","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.5388270616531372},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5248246788978577},{"id":"https://openalex.org/C74534348","wikidata":"https://www.wikidata.org/wiki/Q410798","display_name":"cGMP-specific phosphodiesterase type 5","level":3,"score":0.4543456733226776},{"id":"https://openalex.org/C2776766087","wikidata":"https://www.wikidata.org/wiki/Q418251","display_name":"Phosphodiesterase inhibitor","level":2,"score":0.4477078914642334},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.4476652145385742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42842161655426025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42351484298706055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3436993956565857},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21376752853393555},{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.19941899180412292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1697545051574707}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002304","descriptor_name":"Cardiac Pacing, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010210","descriptor_name":"Papillary Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010210","descriptor_name":"Papillary Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015106","descriptor_name":"3',5'-Cyclic-GMP Phosphodiesterases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018879","descriptor_name":"Ventricular Premature Complexes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018879","descriptor_name":"Ventricular Premature Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018879","descriptor_name":"Ventricular Premature Complexes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054706","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.26.1661","doi":"https://doi.org/10.1248/bpb.26.1661","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.26.1661","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/26/12/26_12_1661/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:14646167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14646167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1248/bpb.26.1661","doi":"https://doi.org/10.1248/bpb.26.1661","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.26.1661","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/26/12/26_12_1661/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007644094.pdf","grobid_xml":"https://content.openalex.org/works/W2007644094.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1967151871","https://openalex.org/W1970058620","https://openalex.org/W1976892262","https://openalex.org/W1990637512","https://openalex.org/W1999933643","https://openalex.org/W2085048839","https://openalex.org/W2090990687","https://openalex.org/W2092524554","https://openalex.org/W2125271591","https://openalex.org/W2136800311","https://openalex.org/W2150242032","https://openalex.org/W2150629896","https://openalex.org/W2187547057","https://openalex.org/W2281355947","https://openalex.org/W2282425761","https://openalex.org/W2416560526","https://openalex.org/W2473838298"],"related_works":["https://openalex.org/W1989931176","https://openalex.org/W2106792651","https://openalex.org/W2168766521","https://openalex.org/W2034172298","https://openalex.org/W2085214106","https://openalex.org/W4286559772","https://openalex.org/W2094794064","https://openalex.org/W2011530952","https://openalex.org/W2013799054","https://openalex.org/W2169831196"],"abstract_inverted_index":{"The":[0,20],"aim":[1],"of":[2,11,46,82,89,117,122,150,174],"this":[3],"study":[4],"was":[5,138],"to":[6,104,112,171],"assess":[7],"the":[8,29,68,96,119,134,147,164,172,175],"cardiovascular":[9],"effects":[10],"a":[12],"selective":[13],"phosphodiesterase":[14],"5":[15],"inhibitor":[16],"ER-118585,":[17],"4-[(3-chloro-4-methoxybenzyl)amino]-1-(2-hydroxy-7-azaspiro[3.5]non-7-yl)-6-phthalazinecarbonitrile":[18],"monohydrochloride.":[19],"present":[21],"results":[22],"indicated":[23],"that":[24,160],"1)":[25],"ER-118585":[26,60,90,123,161],"significantly":[27,66,94],"inhibited":[28],"human":[30,50],"ether-a-go-go":[31],"related":[32],"gene":[33],"(HERG)":[34],"tail":[35],"current":[36,152],"at":[37,61,73,91,140],"10":[38,92],"nM":[39,48,65],"and":[40,63,75,85,127],"above":[41],"with":[42,56,146],"an":[43],"IC(50)":[44],"value":[45],"40.7":[47],"in":[49,78,107],"embryonic":[51],"kidney":[52],"293":[53],"cells":[54],"transfected":[55],"HERG":[57,151,176],"cDNA;":[58],"2)":[59],"100":[62],"1000":[64],"increased":[67],"action":[69],"potential":[70],"duration":[71],"(APD)":[72],"50%":[74],"90%":[76],"repolarization":[77],"isolated":[79],"papillary":[80],"muscles":[81],"guinea":[83],"pig;":[84],"3)":[86],"intravenous":[87],"infusion":[88],"microg/kg/min":[93],"prolonged":[95],"QT":[97,165],"interval":[98,166],"by":[99],"10.5+/-1.6%":[100],"from":[101],"281+/-2":[102],"ms":[103,106],"311+/-6":[105],"six":[108],"anesthetized":[109],"dogs":[110],"subjected":[111],"atrial":[113],"pacing.":[114],"In":[115,154],"consideration":[116],"both":[118],"plasma":[120,136],"concentration":[121,137,149],"(984+/-78":[124],"nM,":[125,142],"n=3)":[126],"its":[128],"protein":[129],"binding":[130],"fraction":[131],"(99.0+/-0.1%,":[132],"n=5),":[133],"free":[135],"estimated":[139],"9.8+/-0.8":[141],"which":[143],"is":[144],"consistent":[145],"minimum":[148],"inhibition.":[153],"conclusion,":[155],"these":[156],"evaluation":[157],"methods":[158],"demonstrated":[159],"could":[162],"prolong":[163],"via":[167],"APD":[168],"prolongation,":[169],"attributable":[170],"inhibition":[173],"potassium":[177],"current.":[178]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}