{"id":"https://openalex.org/W2007635250","doi":"https://doi.org/10.1536/ihj.20.83","title":"Effect of Diltiazem on Coronary Hemodynamics and Its Clinical Significance","display_name":"Effect of Diltiazem on Coronary Hemodynamics and Its Clinical Significance","publication_year":1979,"publication_date":"1979-01-01","ids":{"openalex":"https://openalex.org/W2007635250","doi":"https://doi.org/10.1536/ihj.20.83","mag":"2007635250","pmid":"https://pubmed.ncbi.nlm.nih.gov/449045"},"language":"en","primary_location":{"id":"doi:10.1536/ihj.20.83","doi":"https://doi.org/10.1536/ihj.20.83","is_oa":true,"landing_page_url":"https://doi.org/10.1536/ihj.20.83","pdf_url":"https://www.jstage.jst.go.jp/article/ihj1960/20/1/20_1_83/_pdf","source":{"id":"https://openalex.org/S120602568","display_name":"Japanese Heart Journal","issn_l":"0021-4868","issn":["0021-4868","1348-673X","1573-8612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313504","host_organization_name":"Japanese Heart Journal Assoc","host_organization_lineage":["https://openalex.org/P4310313504"],"host_organization_lineage_names":["Japanese Heart Journal Assoc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/ihj1960/20/1/20_1_83/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112190810","display_name":"Yoshimasa Yabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa YABE","raw_affiliation_strings":["Cardiovascular Invasive Laboratory Center, Toho University School of Medicine","Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Invasive Laboratory Center, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010943454","display_name":"Hiroyuki Ab\u00e9","orcid":"https://orcid.org/0000-0003-4513-1007","observed_orcids":["https://orcid.org/0000-0003-4513-1007"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki ABE","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047306313","display_name":"Shozo Yoshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo YOSHIMURA","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028686657","display_name":"Akiji Tsuzuku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiji TSUZUKU","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108803184","display_name":"Motoharu Hasegawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoharu HASEGAWA","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032310988","display_name":"Yoshihiro Kashiwakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro KASHIWAKURA","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111366493","display_name":"Chikao Arai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikao ARAI","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takeshi KAWASAKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi KAWASAKI","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112271910","display_name":"Masatake ABE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatake ABE","raw_affiliation_strings":["Department of Cardiology, Juntendo University, School of Medicine","Department of Central Clinical Laboratory, Toho University School of Medicine","Fourth Department of Internal Medicine, Jikei University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Juntendo University, School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Central Clinical Laboratory, Toho University School of Medicine","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Fourth Department of Internal Medicine, Jikei University School of Medicine","institution_ids":["https://openalex.org/I115498069"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6482,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.92161175,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"1","first_page":"83","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.5,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.5,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.19349999725818634,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.1914999932050705,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diltiazem","display_name":"diltiazem","score":1.0},{"id":"https://openalex.org/keywords/coronary-hemodynamics","display_name":"coronary hemodynamics","score":0.9070000052452087},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/coronary-vascular-resistance","display_name":"coronary vascular resistance","score":0.699999988079071},{"id":"https://openalex.org/keywords/myocardial-oxygen-consumption","display_name":"myocardial oxygen consumption","score":0.9200000166893005},{"id":"https://openalex.org/keywords/coronary-spasm","display_name":"coronary vasospasm","score":0.7590000033378601},{"id":"https://openalex.org/keywords/variant-angina-pectoris","display_name":"variant angina pectoris","score":0.9739999771118164},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C2776741139","wikidata":"https://www.wikidata.org/wiki/Q422229","display_name":"Diltiazem","level":3,"score":0.873173713684082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7857279181480408},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6968708634376526},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.637637197971344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5898557305335999},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5078464150428772},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5038911700248718},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.49989938735961914},{"id":"https://openalex.org/C39124391","wikidata":"https://www.wikidata.org/wiki/Q4778759","display_name":"Aortic pressure","level":3,"score":0.49762943387031555},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.4730583429336548},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4443933367729187},{"id":"https://openalex.org/C2994477613","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary vessel","level":3,"score":0.4306633472442627},{"id":"https://openalex.org/C2776157398","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary circulation","level":3,"score":0.42108798027038574},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3699274957180023},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.3334970772266388},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2888331115245819},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.08455359935760498}],"mesh":[{"descriptor_ui":"D000788","descriptor_name":"Angina Pectoris, Variant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004110","descriptor_name":"Diltiazem","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004110","descriptor_name":"Diltiazem","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1536/ihj.20.83","doi":"https://doi.org/10.1536/ihj.20.83","is_oa":true,"landing_page_url":"https://doi.org/10.1536/ihj.20.83","pdf_url":"https://www.jstage.jst.go.jp/article/ihj1960/20/1/20_1_83/_pdf","source":{"id":"https://openalex.org/S120602568","display_name":"Japanese Heart Journal","issn_l":"0021-4868","issn":["0021-4868","1348-673X","1573-8612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313504","host_organization_name":"Japanese Heart Journal Assoc","host_organization_lineage":["https://openalex.org/P4310313504"],"host_organization_lineage_names":["Japanese Heart Journal Assoc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Heart Journal","raw_type":"journal-article"},{"id":"pmid:449045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/449045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese heart journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1536/ihj.20.83","doi":"https://doi.org/10.1536/ihj.20.83","is_oa":true,"landing_page_url":"https://doi.org/10.1536/ihj.20.83","pdf_url":"https://www.jstage.jst.go.jp/article/ihj1960/20/1/20_1_83/_pdf","source":{"id":"https://openalex.org/S120602568","display_name":"Japanese Heart Journal","issn_l":"0021-4868","issn":["0021-4868","1348-673X","1573-8612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313504","host_organization_name":"Japanese Heart Journal Assoc","host_organization_lineage":["https://openalex.org/P4310313504"],"host_organization_lineage_names":["Japanese Heart Journal Assoc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007635250.pdf","grobid_xml":"https://content.openalex.org/works/W2007635250.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W1580109706","https://openalex.org/W2076103635"],"related_works":["https://openalex.org/W2063953681","https://openalex.org/W2092947498","https://openalex.org/W2053762563","https://openalex.org/W2045999775","https://openalex.org/W2044271728","https://openalex.org/W2413798552","https://openalex.org/W2417985813","https://openalex.org/W4248260058","https://openalex.org/W1963597054","https://openalex.org/W2050425396"],"abstract_inverted_index":{"A":[0],"small":[1],"electromagnetic":[2],"flowprobe":[3],"was":[4,19,84],"chronically":[5],"implanted":[6],"in":[7,21,31,53,90,115,136,198],"circumflex":[8],"branch":[9],"of":[10,14,25,58,70,108,110,143,152,176,209,216],"left":[11],"coronary":[12,33,60,80,127,134,164],"artery":[13],"mongrel":[15],"dogs.":[16,28],"Diltiazem,":[17],"100\u03bcg/Kg,":[18],"injected":[20],"a":[22,91,137,140,157],"basilic":[23],"vein":[24],"the":[26,68,71,99,106,174,177,196,205,210,217,221],"unanesthetized":[27],"The":[29,55,113],"changes":[30,114,172],"phasic":[32],"flow":[34,61],"as":[35,37],"well":[36],"hemodynamics":[38],"including":[39],"aortic":[40,116],"pressure":[41,117],"(AP),":[42],"heart":[43,120],"rate":[44,121],"(HR),":[45],"and":[46,65,76,119,159,168,192,194],"myocardial":[47,189],"oxygen":[48],"extraction":[49],"ratio":[50],"(OER)":[51],"were":[52,73,123,146],"estigated.":[54],"increasing":[56],"rates":[57],"total":[59],"(TCF)":[62],"5,":[63],"10,":[64],"20min":[66],"after":[67,94,98,149,173],"injection":[69,151,175],"drug":[72,100,211],"90%,":[74],"65%,":[75],"40%":[77],"respectively,":[78],"Total":[79],"vascular":[81],"resistence":[82],"(TCVR)":[83],"inversly":[85],"proportional":[86],"to":[87,105,202],"TCF,":[88],"resulting":[89],"significant":[92],"decrease":[93,197],"injection.":[95],"Five":[96],"min":[97],"administration,":[101],"OER":[102,179,193,199],"markedly":[103],"decreased":[104,180],"level":[107],"-45%":[109],"control":[111],"value.":[112],"(AP)":[118],"(HR)":[122],"unremarkable.In":[124],"clinical":[125],"investigation,":[126],"atrery":[128],"narrowings":[129],"(spasms)":[130],"observed":[131],"by":[132],"cine":[133],"arteriography":[135],"patient":[138],"with":[139],"variant":[141],"form":[142],"angina":[144],"pectoris":[145],"completely":[147],"dilated":[148],"intravenous":[150],"Diltiazem.In":[153],"conclusion,":[154],"Diltiazem":[155,186],"exerted":[156],"powerful":[158],"long-acting":[160],"vasodilator":[161],"action":[162,219],"on":[163,220],"vasculature.":[165],"Although":[166],"AP":[167],"HR":[169],"showed":[170],"unremarkable":[171],"drug,":[178],"significantly.":[181],"Results":[182],"obtained":[183],"suggest":[184],"that":[185,195],"can":[187],"reduce":[188],"oxyge":[190],"consumption":[191],"is":[200],"attributed":[201],"not":[203],"only":[204],"peripheral":[206],"hemodynamic":[207],"effect":[208],"but":[212],"also":[213],"probable":[214],"consequence":[215],"direct":[218],"myocardium.":[222]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}