{"id":"https://openalex.org/W2007621529","doi":"https://doi.org/10.3892/ijmm.12.1.17","title":"Structure of curcumin in complex with lipoxygenase and its significance in cancer","display_name":"Structure of curcumin in complex with lipoxygenase and its significance in cancer","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2007621529","doi":"https://doi.org/10.3892/ijmm.12.1.17","mag":"2007621529","pmid":"https://pubmed.ncbi.nlm.nih.gov/12792803"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.12.1.17","doi":"https://doi.org/10.3892/ijmm.12.1.17","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.12.1.17","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026381921","display_name":"Ewa Skrzypczak\u2010Jankun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ewa Skrzypczak-Jankun","raw_affiliation_strings":["Department of Urology, Urology Research Center, Medical College of Ohio, Toledo, OH 43614-5807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Urology Research Center, Medical College of Ohio, Toledo, OH 43614-5807, USA","institution_ids":["https://openalex.org/I12057038","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100856888","display_name":"Kangjing Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kangjing Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109151907","display_name":"Noel Patrick McCabe","orcid":"https://orcid.org/0000-0003-3131-4523","observed_orcids":["https://orcid.org/0000-0003-3131-4523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. McCabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081142231","display_name":"Steven H. Selman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Selman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079636370","display_name":"Jerzy Jankun","orcid":"https://orcid.org/0000-0003-2354-4046","observed_orcids":["https://orcid.org/0000-0003-2354-4046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerzy Jankun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0962,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.76923077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"17","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/soybean-lipoxygenase","display_name":"soybean lipoxygenase","score":0.984000027179718},{"id":"https://openalex.org/keywords/protein-ligand-complex-structure","display_name":"protein-ligand complex structure","score":0.8080000281333923},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.8320000171661377},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.6230000257492065},{"id":"https://openalex.org/keywords/photodegradation","display_name":"photodegradation","score":0.625},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9377685785293579},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.8501726388931274},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6157543659210205},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5792272686958313},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5747318267822266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5610551238059998},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.5068910717964172},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47398367524147034},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.43719732761383057},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4256758689880371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36202991008758545},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35496896505355835},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3272660970687866},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2893480062484741},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.16483157873153687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09836199879646301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013025","descriptor_name":"Glycine max","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.12.1.17","doi":"https://doi.org/10.3892/ijmm.12.1.17","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.12.1.17","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:12792803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12792803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029140732","https://openalex.org/W1977248100","https://openalex.org/W2082372022","https://openalex.org/W43866122","https://openalex.org/W1963703677","https://openalex.org/W2911235991","https://openalex.org/W1969691912","https://openalex.org/W32597207","https://openalex.org/W2724358403","https://openalex.org/W6903979418"],"abstract_inverted_index":{"Scientific":[0],"research":[1],"provides":[2],"documented":[3],"evidence":[4],"that":[5,61,82,101],"fatty":[6,45],"acid":[7,46],"metabolites":[8],"have":[9],"profound":[10],"impact":[11],"on":[12],"carcinogenesis.":[13],"Intervention":[14],"into":[15,85],"dioxygenase":[16],"pathways":[17],"might":[18,103],"therefore":[19],"effect":[20],"development,":[21],"metastasis":[22],"and":[23,38,92,108],"progression":[24],"of":[25,28],"many":[26],"types":[27],"cancers.":[29],"This":[30],"work":[31],"delivers":[32],"the":[33,44,67,76,99],"first":[34],"3D":[35],"structural":[36],"data":[37],"explains":[39],"how":[40],"curcumin":[41,102],"interacts":[42],"with":[43],"metabolizing":[47],"enzyme,":[48],"soybean":[49],"lipoxygenase.":[50],"Curcumin":[51],"binds":[52],"to":[53,74,98],"lipoxygenase":[54],"in":[55,60,66,105],"a":[56],"non-competitive":[57],"manner.":[58],"Trapped":[59],"complex,":[62],"it":[63],"undergoes":[64],"photodegradation":[65],"X-rays,":[68],"but":[69],"utilizes":[70],"enzyme":[71],"catalytic":[72],"ability":[73],"form":[75],"peroxy":[77],"complex":[78],"Enz-Fe-O-O-R":[79],"as":[80],"4-hydroperoxy-2-methoxy-phenol,":[81],"later":[83],"transforms":[84],"2-methoxycyclohexa-2,5-diene-1,4-dione.":[86],"Our":[87],"observations":[88],"about":[89],"this":[90],"radiation":[91],"time-dependent":[93],"inhibition":[94],"add":[95],"new":[96],"information":[97],"role":[100],"play":[104],"cancer":[106],"prevention":[107],"treatment.":[109]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
