{"id":"https://openalex.org/W2007609448","doi":"https://doi.org/10.1111/iep.12051","title":"Pathobiological properties of the ubiquitin ligase N edd4 L in melanoma","display_name":"Pathobiological properties of the ubiquitin ligase N edd4 L in melanoma","publication_year":2013,"publication_date":"2013-10-31","ids":{"openalex":"https://openalex.org/W2007609448","doi":"https://doi.org/10.1111/iep.12051","mag":"2007609448","pmid":"https://pubmed.ncbi.nlm.nih.gov/24456330","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919647"},"language":"en","primary_location":{"id":"doi:10.1111/iep.12051","doi":"https://doi.org/10.1111/iep.12051","is_oa":false,"landing_page_url":"https://doi.org/10.1111/iep.12051","pdf_url":null,"source":{"id":"https://openalex.org/S82103187","display_name":"International Journal of Experimental Pathology","issn_l":"0959-9673","issn":["0959-9673","1365-2613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Experimental Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3919647/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077313439","display_name":"Yusuke Kito","orcid":"https://orcid.org/0000-0003-1373-986X","observed_orcids":["https://orcid.org/0000-0003-1373-986X","https://orcid.org/0009-0004-3927-222X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Kito","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077501519","display_name":"Juncheng Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Juncheng Bai","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111501694","display_name":"Naoe Goto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoe Goto","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Okubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Okubo","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032105880","display_name":"Yoshihiro Adachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]},{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Adachi","raw_affiliation_strings":["Department of Pathology, Kochi Medical School, Nankoku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kochi Medical School, Nankoku, Japan","institution_ids":["https://openalex.org/I4210088960","https://openalex.org/I77063589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038450850","display_name":"Tomoko Nagayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Nagayama","raw_affiliation_strings":["Innovation Satellite Kochi Practical Application Research, Japan Science and Technology Agency, Kami, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Satellite Kochi Practical Application Research, Japan Science and Technology Agency, Kami, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087997167","display_name":"Tamotsu Takeuchi","orcid":"https://orcid.org/0000-0002-4264-3632","observed_orcids":["https://orcid.org/0000-0002-4264-3632"]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]},{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tamotsu Takeuchi","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan","Department of Pathology, Kochi Medical School, Nankoku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Department of Pathology, Kochi Medical School, Nankoku, Japan","institution_ids":["https://openalex.org/I4210088960","https://openalex.org/I77063589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087997167"],"corresponding_institution_ids":["https://openalex.org/I4210088960","https://openalex.org/I42405503","https://openalex.org/I77063589"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.4399,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.57367281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"1","first_page":"24","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7577999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7577999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.12219999730587006,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nedd4l","display_name":"NEDD4L","score":0.996999979019165},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.4620000123977661},{"id":"https://openalex.org/keywords/benign-nevi","display_name":"benign nevi","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8349999785423279},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8687115907669067},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.6766132116317749},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6307304501533508},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5573893785476685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5555258989334106},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5377699136734009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5093783140182495},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4714456796646118},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4536263048648834},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4184532165527344},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3624873161315918},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29408806562423706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2364099621772766},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.21720629930496216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18661141395568848},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1535148322582245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06426194310188293},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000075702","descriptor_name":"Nedd4 Ubiquitin Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009506","descriptor_name":"Nevus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/iep.12051","doi":"https://doi.org/10.1111/iep.12051","is_oa":false,"landing_page_url":"https://doi.org/10.1111/iep.12051","pdf_url":null,"source":{"id":"https://openalex.org/S82103187","display_name":"International Journal of Experimental Pathology","issn_l":"0959-9673","issn":["0959-9673","1365-2613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Experimental Pathology","raw_type":"journal-article"},{"id":"pmid:24456330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24456330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of experimental pathology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:3919647","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3919647/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Exp Pathol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3919647","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3919647/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1549217097","https://openalex.org/W1967046030","https://openalex.org/W1987067105","https://openalex.org/W1998816680","https://openalex.org/W2002760530","https://openalex.org/W2022600140","https://openalex.org/W2032211985","https://openalex.org/W2034737120","https://openalex.org/W2034886137","https://openalex.org/W2059865316","https://openalex.org/W2063962756","https://openalex.org/W2068729923","https://openalex.org/W2072656506","https://openalex.org/W2101108802","https://openalex.org/W2104165125","https://openalex.org/W2106543129","https://openalex.org/W2128542677","https://openalex.org/W2137672750","https://openalex.org/W2164963523","https://openalex.org/W2171733999","https://openalex.org/W4240567369"],"related_works":["https://openalex.org/W3203322025","https://openalex.org/W6992986242","https://openalex.org/W2341663329","https://openalex.org/W2115451846","https://openalex.org/W2303083768","https://openalex.org/W4285744346","https://openalex.org/W2476298187","https://openalex.org/W4383482612","https://openalex.org/W4393946199","https://openalex.org/W2471949562"],"abstract_inverted_index":{"A":[0],"recent":[1],"global":[2],"gene":[3],"expression":[4,53,131,152],"profiling":[5],"study":[6],"unexpectedly":[7],"showed":[8],"that":[9,82,150],"activated":[10],"oncogenic":[11],"NRAS":[12],"may":[13,153],"recruit":[14],"neural":[15],"precursor":[16],"cell":[17,77],"expressed,":[18],"developmentally":[19],"downregulated":[20],"4L":[21],"(Nedd4L;":[22],"a":[23,143],"human":[24,58],"homologue":[25],"of":[26,55,73,103,109,115,121,136],"Nedd4-2)":[27],"in":[28,37,42,57,75,87,92,101,126,140,142,160],"cultured":[29,122],"melanoma":[30,38,43,63,76,124,138],"cells.":[31],"However,":[32],"whether":[33],"Nedd4L":[34,56,74,83,116,130,151],"was":[35,84,99],"expressed":[36],"tissues":[39],"or":[40,91],"participated":[41],"carcinogenesis":[44],"remains":[45],"to":[46,69,156],"be":[47,154],"clarified.":[48],"Here,":[49],"we":[50],"investigated":[51],"the":[52,71,119,134],"status":[54],"melanocytes,":[59],"benign":[60,94],"nevi":[61,95],"and":[62,66,107],"tissue":[64],"specimens":[65],"subsequently":[67],"attempted":[68],"determine":[70],"role":[72],"growth.":[78],"Immunohistochemical":[79],"staining":[80],"revealed":[81],"not":[85],"present":[86,147],"any":[88],"non-tumorous":[89],"melanocytes":[90],"18":[93],"tissues,":[96],"but":[97],"it":[98],"detected":[100],"34":[102],"79":[104],"cutaneous":[105],"melanomas":[106],"9":[108],"32":[110],"nodal":[111],"metastatic":[112],"melanomas.":[113,162],"Downregulation":[114],"significantly":[117,132],"reduced":[118],"growth":[120,135,159],"G361":[123],"cells":[125,139],"vitro.":[127],"Moreover,":[128],"exogenous":[129],"promoted":[133],"A2058":[137],"vivo":[141],"xenograft":[144],"assay.":[145],"The":[146],"findings":[148],"indicate":[149],"increased":[155],"facilitate":[157],"tumour":[158],"many":[161]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}