{"id":"https://openalex.org/W2007606643","doi":"https://doi.org/10.1902/jop.2007.060216","title":"Salivary Enzyme Levels After Scaling and Interleukin\u20101 Genotypes in Japanese Patients With Chronic Periodontitis","display_name":"Salivary Enzyme Levels After Scaling and Interleukin\u20101 Genotypes in Japanese Patients With Chronic Periodontitis","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W2007606643","doi":"https://doi.org/10.1902/jop.2007.060216","mag":"2007606643","pmid":"https://pubmed.ncbi.nlm.nih.gov/17335373"},"language":"en","primary_location":{"id":"doi:10.1902/jop.2007.060216","doi":"https://doi.org/10.1902/jop.2007.060216","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2007.060216","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005447574","display_name":"Hiromasa Yoshie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiromasa Yoshie","raw_affiliation_strings":["Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. yoshie@dent.niigata-u.ac.jp","Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. yoshie@dent.niigata-u.ac.jp","institution_ids":["https://openalex.org/I71395657"]},{"raw_affiliation_string":"Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043435291","display_name":"\u79c0\u660e \u7530\u4e95","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Tai","raw_affiliation_strings":["Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101578769","display_name":"Tetsuo Kobayashi","orcid":"https://orcid.org/0000-0001-8250-4234","observed_orcids":["https://orcid.org/0000-0001-8250-4234"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Kobayashi","raw_affiliation_strings":["Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033239239","display_name":"Emire Gou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emire Oda\u2010Gou","raw_affiliation_strings":["Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076592756","display_name":"Yoshiaki Nomura","orcid":"https://orcid.org/0000-0002-0814-0572","observed_orcids":["https://orcid.org/0000-0002-0814-0572"]},"institutions":[{"id":"https://openalex.org/I114171174","display_name":"Tsurumi University","ror":"https://ror.org/04j8wth34","country_code":"JP","type":"education","lineage":["https://openalex.org/I114171174"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Nomura","raw_affiliation_strings":["Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine, Kanagawa, Japan","institution_ids":["https://openalex.org/I114171174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083110344","display_name":"Yukihiro Numabe","orcid":"https://orcid.org/0000-0002-4310-9861","observed_orcids":["https://orcid.org/0000-0002-4310-9861"]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Numabe","raw_affiliation_strings":["Department of Periodontology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112213636","display_name":"Kohichi Ito","orcid":"https://orcid.org/0000-0002-2341-3620","observed_orcids":["https://orcid.org/0000-0002-2341-3620"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohichi Ito","raw_affiliation_strings":["Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070040943","display_name":"Hidemi Kurihara","orcid":"https://orcid.org/0000-0002-3446-6904","observed_orcids":["https://orcid.org/0000-0002-3446-6904","https://orcid.org/0009-0006-3629-6706"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidemi Kurihara","raw_affiliation_strings":["Division of Frontier Medical Science, Department of Periodontal Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Frontier Medical Science, Department of Periodontal Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110351877","display_name":"Kyuichi Kamoi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyuichi Kamoi","raw_affiliation_strings":["Department of Periodontology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I35552710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005447574"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.2293,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.83822108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"78","issue":"3","first_page":"498","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-periodontitis","display_name":"chronic periodontitis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/salivary-enzymes","display_name":"salivary enzymes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":1.0},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":1.0},{"id":"https://openalex.org/keywords/scaling-and-root-planing","display_name":"scaling and root planing","score":0.8930000066757202},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.6980000138282776},{"id":"https://openalex.org/keywords/probing-depth","display_name":"probing depth","score":0.7570000290870667},{"id":"https://openalex.org/keywords/clinical-attachment-level","display_name":"clinical attachment level","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bleeding-on-probing","display_name":"bleeding on probing","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.8909350633621216},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.581458568572998},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.5760284662246704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5642461776733398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5365481376647949},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5323747992515564},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4878549575805664},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.4763484299182892},{"id":"https://openalex.org/C2777968807","wikidata":"https://www.wikidata.org/wiki/Q4925923","display_name":"Bleeding on probing","level":3,"score":0.4107230603694916},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4104991853237152},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3920592665672302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29987630248069763},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.20884832739830017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14924806356430054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07492557168006897}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010512","descriptor_name":"Periodontal Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012534","descriptor_name":"Dental Scaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1902/jop.2007.060216","doi":"https://doi.org/10.1902/jop.2007.060216","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2007.060216","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},{"id":"pmid:17335373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17335373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W68747351","https://openalex.org/W656938549","https://openalex.org/W1810878070","https://openalex.org/W1914739190","https://openalex.org/W1985802462","https://openalex.org/W1997895757","https://openalex.org/W2010088585","https://openalex.org/W2011631635","https://openalex.org/W2027665553","https://openalex.org/W2040541004","https://openalex.org/W2049388309","https://openalex.org/W2062912033","https://openalex.org/W2068523722","https://openalex.org/W2074496856","https://openalex.org/W2087501845","https://openalex.org/W2089132119","https://openalex.org/W2096271678","https://openalex.org/W2103367968","https://openalex.org/W2105446060","https://openalex.org/W2115681684","https://openalex.org/W2118427654","https://openalex.org/W2119873569","https://openalex.org/W2128462512","https://openalex.org/W2135352079","https://openalex.org/W2144275571","https://openalex.org/W2156121631","https://openalex.org/W2171485039","https://openalex.org/W2174911894","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7216841431","https://openalex.org/W2151308396","https://openalex.org/W4248804795","https://openalex.org/W2973375122","https://openalex.org/W2958696065","https://openalex.org/W2182815384","https://openalex.org/W1965793694","https://openalex.org/W2552452737","https://openalex.org/W2183023714","https://openalex.org/W7065510908"],"abstract_inverted_index":{"BACKGROUND:":[0],"Saliva":[1],"has":[2],"been":[3,28],"used":[4],"as":[5,30],"a":[6,326],"diagnostic":[7],"fluid":[8],"in":[9,25,91,142,204,215,225,294,297,329,337,348],"medicine":[10],"and":[11,54,60,82,106,111,122,133,159,169,185,217,234,243,253,263,277,300,310,332,365,370,400],"dentistry.":[12],"It":[13],"is":[14],"easy":[15],"to":[16,41,61,199,210,221,256,339],"collect":[17],"using":[18],"non-invasive":[19],"methods.":[20],"The":[21,35,229,280],"intracellular":[22],"enzymes":[23,354],"present":[24],"saliva":[26,117],"have":[27],"studied":[29],"markers":[31,378],"of":[32,37,47,65,95,113,129,231,283,315,352,372,397],"periodontal":[33,373,380],"disease.":[34],"purpose":[36],"this":[38,92],"study":[39],"was":[40,137,148,163,176,288,292],"determine":[42],"the":[43,63,166,284,295,305,320,340,349,353],"salivary":[44,130,330,350,362,398],"enzyme":[45,71,157],"levels":[46,334,351,367],"aspartate":[48],"aminotransferase":[49,52],"(AST),":[50],"alanine":[51],"(ALT),":[53],"lactate":[55],"dehydrogenase":[56],"(LDH)":[57],"after":[58,125,190,268,302,355],"scaling":[59,191,303],"clarify":[62],"influence":[64,389,394],"interleukin":[66],"(IL)-1":[67],"genotypes":[68],"on":[69,108],"these":[70],"levels.":[72],"METHODS:":[73],"Forty-nine":[74],"Japanese":[75],"patients":[76],"with":[77],"chronic":[78],"periodontitis":[79],"(24":[80],"men":[81],"25":[83],"women;":[84],"mean":[85],"age:":[86],"55.1":[87],"years)":[88],"were":[89,118,236],"enrolled":[90],"study.":[93],"Measurements":[94],"clinical":[96,102,390],"parameters":[97],"including":[98],"probing":[99,109],"depth":[100],"(PD),":[101],"attachment":[103],"level":[104],"(CAL),":[105],"bleeding":[107],"(BOP)":[110],"collections":[112],"stimulated":[114],"whole":[115,143],"mixed":[116],"performed":[119,164],"at":[120,178,251],"baseline":[121],"4":[123],"weeks":[124],"scaling.":[126,356],"After":[127],"evaluation":[128],"AST,":[131,232,363],"ALT,":[132,233,364],"LDH":[134,235,366],"levels,":[135],"DNA":[136],"extracted":[138],"from":[139],"various":[140],"cells":[141],"saliva.":[144],"IL-1A+4845":[145,285,316,385],"G/T":[146],"genotype":[147],"determined":[149],"by":[150,156,165],"polymerase":[151],"chain":[152],"reaction":[153],"amplification,":[154],"followed":[155],"digestion":[158],"electrophoresis.":[160],"Statistical":[161],"analysis":[162],"Wilcoxon":[167],"signed-rank":[168],"Mann-Whitney":[170],"U":[171],"tests.":[172],"A":[173],"significant":[174,327],"difference":[175,291],"set":[177],"P":[179,274,278],"<0.05.":[180],"RESULTS:":[181],"Mean":[182],"PD,":[183,298],"CAL,":[184,299],"BOP":[186,301],"values":[187,230,396],"significantly":[188,254],"decreased":[189,255],"(mean":[192],"+/-":[193,196,201,207,212,219,223,238,241,245,258,261,265],"SE:":[194],"3.2":[195],"0.1":[197,202],"mm":[198,203,209,214],"2.6":[200],"PD;":[205],"3.9":[206],"0.2":[208,213],"3.3":[211],"CAL;":[216],"41%":[218],"4%":[220],"18%":[222],"3%":[224],"BOP)":[226],"(P":[227,271,335],"<0.001).":[228,279],"77.0":[237],"7.5,":[239],"43.9":[240],"5.5,":[242,262],"753.4":[244],"96.5":[246],"(units":[247],"per":[248],"liter":[249],"[U/l])":[250],"baseline,":[252],"55.5":[257],"6.5,":[259],"30.0":[260],"394.7":[264],"34.0":[266],"(U/l)":[267],"scaling,":[269],"respectively":[270],"=":[272,275,308,313],"0.01,":[273],"0.006,":[276],"carriage":[281],"rate":[282],"allele":[286,317,322],"2":[287,323],"24.5%.":[289],"No":[290],"noted":[293],"decrease":[296,328],"between":[304],"carriers":[306,341],"(N":[307,312],"12)":[309],"non-carriers":[311,324],"37)":[314],"2.":[318],"However,":[319],"IL-1A":[321],"displayed":[325],"AST":[331,399],"ALT":[333],"<0.001),":[336],"contrast":[338],"who":[342],"did":[343],"not":[344,388],"show":[345],"any":[346],"changes":[347],"CONCLUSIONS:":[357],"These":[358],"results":[359],"documented":[360],"that":[361],"reflect":[368],"inflammation":[369],"destruction":[371],"tissue,":[374],"suggesting":[375],"clinically":[376],"useful":[377],"following":[379],"therapy.":[381],"In":[382],"addition,":[383],"although":[384],"alleles":[386],"may":[387,393],"parameters,":[391],"they":[392],"post-scaling":[395],"ALT.":[401]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}