{"id":"https://openalex.org/W200760422","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","title":"Mesothelin-targeted immunotherapies for malignant pleural mesothelioma.","display_name":"Mesothelin-targeted immunotherapies for malignant pleural mesothelioma.","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W200760422","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","mag":"200760422","pmid":"https://pubmed.ncbi.nlm.nih.gov/23977538"},"language":"en","primary_location":{"id":"pmid:23977538","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23977538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of cardiothoracic surgery","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3741795","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087032287","display_name":"Jonathan Villena\u2010Vargas","orcid":"https://orcid.org/0000-0002-8248-666X","observed_orcids":["https://orcid.org/0000-0002-8248-666X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Villena-Vargas","raw_affiliation_strings":["Center for Cell Engineering and Department of Surgery, Thoracic Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell Engineering and Department of Surgery, Thoracic Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034626553","display_name":"Prasad S. Adusumilli","orcid":"https://orcid.org/0000-0002-1699-2046","observed_orcids":["https://orcid.org/0000-0002-1699-2046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prasad S Adusumilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6594,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84184314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"4","first_page":"466","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mesothelin","display_name":"mesothelin","score":1.0},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cell-surface-antigens","display_name":"cell surface antigens","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.8119999766349792},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8970000147819519},{"id":"https://openalex.org/keywords/immunotoxins","display_name":"immunotoxins","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.8180000185966492},{"id":"https://openalex.org/keywords/genetically-modified-t-cells","display_name":"genetically modified T cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.8190000057220459},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2777045440","wikidata":"https://www.wikidata.org/wiki/Q14914057","display_name":"Mesothelin","level":3,"score":0.9739161133766174},{"id":"https://openalex.org/C115085202","wikidata":"https://www.wikidata.org/wiki/Q425665","display_name":"Immunotoxin","level":4,"score":0.7362991571426392},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.730209469795227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7288487553596497},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.6624201536178589},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6580579280853271},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6499249935150146},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5994917750358582},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.551189661026001},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45970970392227173},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4412885308265686},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.42042112350463867},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38820958137512207},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33908796310424805},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2199866771697998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.134996235370636}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:23977538","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23977538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of cardiothoracic surgery","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2740959","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3741795","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3741795","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3741795","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ann Cardiothorac Surg","raw_type":"Text"},{"id":"mag:200760422","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23977538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3741795","doi":"https://doi.org/10.3978/j.issn.2225-319x.2012.10.03","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3741795","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ann Cardiothorac Surg","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1287360046","display_name":"Mesothelin as a biomarker for clinical management of esophageal adenocarcinoma","funder_award_id":"5r21ca164585-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1820159704","display_name":null,"funder_award_id":"U54CA137788","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2504619680","display_name":null,"funder_award_id":"R21-CA164585","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G333081973","display_name":null,"funder_award_id":"T32 CA009501","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5832649626","display_name":null,"funder_award_id":"R21CA164568","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000920523","display_name":"1/2 CCNY-MSK Partnership for Cancer Research, Education and Community Outreach","funder_award_id":"U54CA132378","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1502761305","https://openalex.org/W1966327293","https://openalex.org/W1968961516","https://openalex.org/W1977122810","https://openalex.org/W1979568379","https://openalex.org/W2000219927","https://openalex.org/W2015961605","https://openalex.org/W2037015426","https://openalex.org/W2037954581","https://openalex.org/W2046562334","https://openalex.org/W2047420649","https://openalex.org/W2050658031","https://openalex.org/W2059473079","https://openalex.org/W2062062378","https://openalex.org/W2093654081","https://openalex.org/W2097734025","https://openalex.org/W2097851464","https://openalex.org/W2100588878","https://openalex.org/W2101371847","https://openalex.org/W2107806760","https://openalex.org/W2112041130","https://openalex.org/W2117688944","https://openalex.org/W2118546583","https://openalex.org/W2119289025","https://openalex.org/W2121394047","https://openalex.org/W2121834538","https://openalex.org/W2122465970","https://openalex.org/W2133044118","https://openalex.org/W2133215361","https://openalex.org/W2135339053","https://openalex.org/W2139399500","https://openalex.org/W2139960999","https://openalex.org/W2145112123","https://openalex.org/W2153375051","https://openalex.org/W2158059172","https://openalex.org/W2160438188","https://openalex.org/W2167461988","https://openalex.org/W2172175430","https://openalex.org/W2332192134"],"related_works":["https://openalex.org/W2167461988","https://openalex.org/W2160261768","https://openalex.org/W2133044118","https://openalex.org/W2122465970","https://openalex.org/W2117688944","https://openalex.org/W2107806760","https://openalex.org/W2099570622","https://openalex.org/W1969194497","https://openalex.org/W2169876627","https://openalex.org/W2168091280","https://openalex.org/W2153021843","https://openalex.org/W2150869832","https://openalex.org/W2139399500","https://openalex.org/W2133298966","https://openalex.org/W2133215361","https://openalex.org/W2127033802","https://openalex.org/W2104597364","https://openalex.org/W2101371847","https://openalex.org/W2066186103","https://openalex.org/W2037015426"],"abstract_inverted_index":{"Despite":[0],"the":[1,15,102],"use":[2,69],"of":[3,8,18,70,106,109],"aggressive":[4],"trimodality":[5],"therapy":[6],"consisting":[7],"neoadjuvant":[9],"chemotherapy,":[10],"surgery,":[11],"and":[12],"hemithoracic":[13],"radiation,":[14],"median":[16],"survival":[17],"patients":[19,41],"with":[20],"malignant":[21],"pleural":[22],"mesothelioma":[23,66],"(MPM)":[24],"is":[25,52],"12":[26],"to":[27,36],"18":[28],"months":[29],"(1,2).":[30],"Immune":[31],"responses":[32,51],"have":[33],"been":[34],"shown":[35],"be":[37,84],"beneficial":[38],"in":[39],"MPM":[40],"(3,4);":[42],"therefore,":[43],"focusing":[44],"immunotherapeutic":[45,103],"strategies":[46],"on":[47,65],"promoting":[48],"these":[49],"immune":[50],"an":[53],"attractive":[54],"approach.":[55],"One":[56],"such":[57,88,94],"approach":[58,104],"involves":[59],"targeting":[60],"cancer-associated":[61],"antigens":[62,82,98],"highly":[63],"expressed":[64],"cells":[67],"by":[68],"monoclonal":[71],"antibodies,":[72],"recombinant":[73],"immunotoxins,":[74],"vaccines,":[75],"or":[76,91],"genetically":[77],"engineered":[78],"T":[79],"cells.":[80],"Targeted":[81],"can":[83],"either":[85],"cell-surface":[86],"antigens,":[87,93],"as":[89,95],"mesothelin,":[90],"intracellular":[92],"WT-1.":[96],"Cell-surface":[97],"are":[99],"favored":[100],"for":[101],"because":[105],"their":[107],"ease":[108],"targeting.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}