{"id":"https://openalex.org/W2007509612","doi":"https://doi.org/10.1016/j.jhep.2008.09.002","title":"Plasmacytoid dendritic cells move down on the list of suspects: In search of the immune pathogenesis of chronic hepatitis C","display_name":"Plasmacytoid dendritic cells move down on the list of suspects: In search of the immune pathogenesis of chronic hepatitis C","publication_year":2008,"publication_date":"2008-09-30","ids":{"openalex":"https://openalex.org/W2007509612","doi":"https://doi.org/10.1016/j.jhep.2008.09.002","mag":"2007509612","pmid":"https://pubmed.ncbi.nlm.nih.gov/18929418"},"language":"en","primary_location":{"id":"doi:10.1016/j.jhep.2008.09.002","doi":"https://doi.org/10.1016/j.jhep.2008.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhep.2008.09.002","pdf_url":"http://www.journal-of-hepatology.eu/article/S0168827808006041/pdf","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.journal-of-hepatology.eu/article/S0168827808006041/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078075662","display_name":"Matthew L. Albert","orcid":"https://orcid.org/0000-0001-7285-6973","observed_orcids":["https://orcid.org/0000-0001-7285-6973","https://orcid.org/0000-0002-6910-3708"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Matthew L. Albert","raw_affiliation_strings":["The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France. albertm@pasteur.fr","INSERM U818, Paris, France","The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France. albertm@pasteur.fr","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"INSERM U818, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036412535","display_name":"J\u00e9r\u00e9mie Decalf","orcid":"https://orcid.org/0000-0002-1113-6128","observed_orcids":["https://orcid.org/0000-0002-1113-6128"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00e9mie Decalf","raw_affiliation_strings":["INSERM U818, Paris, France","The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U818, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076282431","display_name":"Stanislas Pol","orcid":"https://orcid.org/0000-0001-9772-9591","observed_orcids":["https://orcid.org/0000-0001-9772-9591","https://orcid.org/0000-0003-0763-0411"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stanislas Pol","raw_affiliation_strings":["Liver Unit (L8), H\u00f4pital Cochin, Paris, France","U568, INSERM, Paris, France","Universit\u00e9 Paris V, Ren\u00e9 Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Unit (L8), H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774"]},{"raw_affiliation_string":"U568, INSERM, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris V, Ren\u00e9 Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078075662"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":0.5188,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.44036697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"49","issue":"6","first_page":"1069","last_page":"1078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9769999980926514},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7179999947547913},{"id":"https://openalex.org/keywords/hcv-specific-t-cells","display_name":"HCV-specific T cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immunological-pathogenesis","display_name":"immune pathogenesis","score":0.671999990940094},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6200000047683716},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.7009999752044678},{"id":"https://openalex.org/keywords/hcv-clearance","display_name":"HCV clearance","score":0.5550000071525574},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7625272274017334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6664925217628479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6652262210845947},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.5972716212272644},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5840195417404175},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5063978433609009},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5014712810516357},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4280858337879181},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.41801512241363525},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09300252795219421}],"mesh":[{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jhep.2008.09.002","doi":"https://doi.org/10.1016/j.jhep.2008.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhep.2008.09.002","pdf_url":"http://www.journal-of-hepatology.eu/article/S0168827808006041/pdf","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},{"id":"pmid:18929418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18929418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:pasteur-01402296v1","doi":null,"is_oa":true,"landing_page_url":"https://pasteur.hal.science/pasteur-01402296v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hepatology, 2008, 49 (6), pp.1069 - 1078. ⟨10.1016/j.jhep.2008.09.002⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.jhep.2008.09.002","doi":"https://doi.org/10.1016/j.jhep.2008.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhep.2008.09.002","pdf_url":"http://www.journal-of-hepatology.eu/article/S0168827808006041/pdf","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007509612.pdf","grobid_xml":"https://content.openalex.org/works/W2007509612.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W180380532","https://openalex.org/W1489480103","https://openalex.org/W1517310071","https://openalex.org/W1584448102","https://openalex.org/W1644577573","https://openalex.org/W1661544713","https://openalex.org/W1667435701","https://openalex.org/W1778677407","https://openalex.org/W1808881512","https://openalex.org/W1980312274","https://openalex.org/W1981746803","https://openalex.org/W1985680307","https://openalex.org/W1990953509","https://openalex.org/W1993023565","https://openalex.org/W1993617345","https://openalex.org/W1993682195","https://openalex.org/W1995744706","https://openalex.org/W1997384271","https://openalex.org/W2002406225","https://openalex.org/W2003807404","https://openalex.org/W2007811342","https://openalex.org/W2015199158","https://openalex.org/W2015489330","https://openalex.org/W2022077416","https://openalex.org/W2026101939","https://openalex.org/W2027349186","https://openalex.org/W2027545702","https://openalex.org/W2028537798","https://openalex.org/W2029323175","https://openalex.org/W2032736796","https://openalex.org/W2039772384","https://openalex.org/W2041670467","https://openalex.org/W2043519223","https://openalex.org/W2043976325","https://openalex.org/W2047208492","https://openalex.org/W2047711008","https://openalex.org/W2059384462","https://openalex.org/W2071267501","https://openalex.org/W2075147482","https://openalex.org/W2076321236","https://openalex.org/W2077467499","https://openalex.org/W2079266303","https://openalex.org/W2082892689","https://openalex.org/W2085604315","https://openalex.org/W2093579074","https://openalex.org/W2093865462","https://openalex.org/W2097224767","https://openalex.org/W2101682111","https://openalex.org/W2107749930","https://openalex.org/W2109450812","https://openalex.org/W2109622861","https://openalex.org/W2114799524","https://openalex.org/W2118647619","https://openalex.org/W2123076394","https://openalex.org/W2124999867","https://openalex.org/W2127685726","https://openalex.org/W2128121593","https://openalex.org/W2128963820","https://openalex.org/W2130098994","https://openalex.org/W2130121394","https://openalex.org/W2130766925","https://openalex.org/W2133692384","https://openalex.org/W2134175118","https://openalex.org/W2138579921","https://openalex.org/W2139169187","https://openalex.org/W2140734388","https://openalex.org/W2146366329","https://openalex.org/W2147126871","https://openalex.org/W2147727360","https://openalex.org/W2150098469","https://openalex.org/W2152506648","https://openalex.org/W2152620027","https://openalex.org/W2160174559","https://openalex.org/W2160739580","https://openalex.org/W2169686453","https://openalex.org/W2169933147","https://openalex.org/W2333452860","https://openalex.org/W2889440541"],"related_works":["https://openalex.org/W3214418488","https://openalex.org/W2114799524","https://openalex.org/W2002442746","https://openalex.org/W7100381216","https://openalex.org/W6980683661","https://openalex.org/W7055431872","https://openalex.org/W2580231239","https://openalex.org/W2082892689","https://openalex.org/W2152620027","https://openalex.org/W7095790496"],"abstract_inverted_index":{"Chronic":[0],"hepatitis":[1,21],"C":[2,22],"is":[3,78,89],"a":[4,183],"major":[5],"public":[6],"health":[7],"problem.":[8],"Despite":[9],"numerous":[10],"clinical":[11,31],"studies":[12],"in":[13,19,46,142,151,163,180,187],"humans":[14],"and":[15,35,38,70,99,146],"experimental":[16],"observations":[17],"made":[18],"chimpanzees,":[20],"pathogenesis":[23,48],"remains":[24],"poorly":[25],"understood.":[26],"Here,":[27],"we":[28],"review":[29,131],"the":[30,40,43,47,55,65,92,97,102,113,123,132,137,176],"features":[32],"of":[33,42,49,54,58,64,104,140,174],"acute":[34,68],"chronic":[36,74,143],"disease,":[37],"discuss":[39],"role":[41,57],"immune":[44],"system":[45],"disease.":[50],"Many":[51],"are":[52,160],"aware":[53],"dual":[56],"T":[59,87],"cells:":[60],"responsibility":[61],"for":[62,91,101,194],"clearance":[63],"virus":[66],"during":[67,73],"phase;":[69],"liver":[71],"injury":[72],"phase.":[75],"Nonetheless,":[76],"there":[77],"an":[79,168],"emerging":[80],"belief":[81],"that":[82],"failure":[83,93],"to":[84,94,106,121,156,166,189],"prime":[85],"HCV-specific":[86],"cells":[88,118],"responsible":[90],"spontaneously":[95],"clear":[96],"virus,":[98],"possibly,":[100],"lack":[103],"response":[105],"pegylated-IFNalpha(2a)/ribavirin":[107],"therapy.":[108],"We":[109,130],"have":[110],"focused":[111],"on":[112],"latest":[114],"suspects,":[115],"plasmacytoid":[116],"dendritic":[117],"(pDCs),":[119],"considered":[120],"be":[122],"professional":[124],"type":[125],"I":[126],"IFNs":[127],"producing":[128],"cells.":[129],"somewhat":[133],"contradictory":[134],"data":[135],"regarding":[136],"functional":[138],"capacity":[139],"pDCs":[141,178],"HCV":[144,196],"patients":[145],"argue":[147],"that,":[148],"while":[149],"lower":[150],"relative":[152],"concentration":[153],"as":[154],"compared":[155],"healthy":[157],"individuals,":[158],"they":[159],"not":[161],"defective":[162],"their":[164],"ability":[165],"initiate":[167],"innate":[169],"inflammatory":[170],"response.":[171],"Thus,":[172],"instead":[173],"being":[175],"culprit,":[177],"may":[179],"fact":[181],"represent":[182],"novel":[184],"therapeutic":[185],"target":[186],"order":[188],"improve":[190],"upon":[191],"existing":[192],"therapies":[193],"treating":[195],"patients.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}