{"id":"https://openalex.org/W200750902","doi":null,"title":"[Silibinin and its hepatoprotective action from the perspective of a toxicologist].","display_name":"[Silibinin and its hepatoprotective action from the perspective of a toxicologist].","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W200750902","mag":"200750902","pmid":"https://pubmed.ncbi.nlm.nih.gov/23243923"},"language":"pl","primary_location":{"id":"pmid:23243923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23243923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad lekarski","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041242415","display_name":"Halina Kostek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Halina Kostek","raw_affiliation_strings":["Samodzielny Publiczny Szpital Wojew\u00f3dzki im. Jana Bozego w Lublinie, Regionalny O\u015brodek Toksykologii Klinicznej"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samodzielny Publiczny Szpital Wojew\u00f3dzki im. Jana Bozego w Lublinie, Regionalny O\u015brodek Toksykologii Klinicznej","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046919110","display_name":"Jaros\u0142aw Szponar","orcid":"https://orcid.org/0000-0001-9915-0719","observed_orcids":["https://orcid.org/0000-0001-9915-0719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaros\u0142aw Szponar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045989069","display_name":"Micha\u0142 Tch\u00f3rz","orcid":"https://orcid.org/0000-0002-1308-099X","observed_orcids":["https://orcid.org/0000-0002-1308-099X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micha\u0142 Tch\u00f3rz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103559901","display_name":"Magdalena Majewska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Majewska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068553279","display_name":"Hanna Lewandowska-Stanek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanna Lewandowska-Stanek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.717,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71144887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"69","issue":"8","first_page":"541","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silibinin","display_name":"silibinin","score":0.984000027179718},{"id":"https://openalex.org/keywords/silymarin","display_name":"silymarin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/milk-thistle","display_name":"Silybum marianum","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.5720000267028809},{"id":"https://openalex.org/keywords/apoptosis-inhibition","display_name":"apoptosis inhibition","score":0.5519999861717224},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7749999761581421},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8840000033378601},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.949999988079071},{"id":"https://openalex.org/keywords/prostaglandin-synthesis","display_name":"prostaglandin synthesis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.8159999847412109},{"id":"https://openalex.org/keywords/amanita-phalloides-poisoning","display_name":"Amanita phalloides poisoning","score":0.9570000171661377},{"id":"https://openalex.org/keywords/amanitin","display_name":"amanitin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/alcoholic-cirrhosis","display_name":"alcoholic cirrhosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/encephalopathy","display_name":"encephalopathy","score":0.796999990940094},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6460000276565552},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2777130413","wikidata":"https://www.wikidata.org/wiki/Q425702","display_name":"Silibinin","level":2,"score":0.9895557165145874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6168704628944397},{"id":"https://openalex.org/C2780210117","wikidata":"https://www.wikidata.org/wiki/Q193798","display_name":"Silybum marianum","level":2,"score":0.4872552454471588},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.47558581829071045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4618157148361206},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.4390597343444824},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4112016260623932},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.4105464816093445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39836713671684265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34057387709617615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3382623791694641},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.28357231616973877},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.17400497198104858},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12398472428321838}],"mesh":[{"descriptor_ui":"D000077385","descriptor_name":"Silybin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000545","descriptor_name":"Amanita","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000546","descriptor_name":"Amanitins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000546","descriptor_name":"Amanitins","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009145","descriptor_name":"Mushroom Poisoning","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009145","descriptor_name":"Mushroom Poisoning","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23243923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23243923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad lekarski","raw_type":"Journal Article"},{"id":"mag:200750902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23243923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2144934601","https://openalex.org/W2227166090","https://openalex.org/W2080246366","https://openalex.org/W4200534598","https://openalex.org/W3209152272","https://openalex.org/W1973760627","https://openalex.org/W1979215811","https://openalex.org/W2921427583","https://openalex.org/W2143894406","https://openalex.org/W945694163"],"abstract_inverted_index":{"Silibinin":[0,102],"is":[1,23,148,172,230,232,245],"the":[2,32,38,47,55,60,70,79,92,97,100,106,110,116,125,133,143,149,176,184,200,207,210,222,233,236,243,257],"most":[3],"active":[4],"component":[5],"of":[6,9,21,40,81,94,99,112,122,127,135,145,151,170,175,186,202,209,213,224,238,259],"a":[7,146,190],"complex":[8,24],"flavonoids":[10],"-silymarin":[11],"contained":[12],"in":[13,28,51,153,160,173,193,199,206,221,242],"fruit":[14],"milk":[15],"thistle":[16],"(Sylibum":[17],"marianum).":[18],"Its":[19],"mechanism":[20],"action":[22],"and":[25,58,85,96,104,119,130,196,219,226,250],"highly":[26],"beneficial":[27,168,249],"protecting":[29],"hepatocytes.":[30,137],"On":[31],"one":[33],"hand":[34],"this":[35,52,161],"compound":[36],"blocks":[37],"penetration":[39],"various":[41],"toxins":[42],"(for":[43],"example":[44],"amanitin)":[45],"into":[46],"hepatocytes":[48],"not":[49],"allowing":[50],"way":[53],"for":[54],"cell":[56,107],"death":[57],"on":[59,132],"other":[61,167],"hand,":[62],"it":[63,263],"prevents":[64],"apoptosis":[65],"through":[66,124],"intracellular.":[67],"It":[68],"protects":[69],"liver":[71,123,178,217],"from":[72,142],"oxidative":[73],"intracellular":[74],"free":[75],"radicals":[76],"by":[77,90],"increasing":[78,91],"activity":[80,98],"enzyme":[82],"superoxide":[83],"dismutase":[84],"peroxidase,":[86],"as":[87,89],"well":[88],"concentration":[93],"glutathione":[95],"peroxidase.":[101],"strengthens":[103],"stabilizes":[105],"membranes,":[108],"inhibits":[109],"synthesis":[111,129],"prostaglandins":[113],"associated":[114],"with":[115,204],"lipid":[117],"peroxidation":[118],"promotes":[120],"regeneration":[121],"stimulation":[126],"protein":[128],"effect":[131],"production":[134],"new":[136],"A":[138],"particularly":[139],"interesting":[140,231],"topic":[141],"perspective":[144],"toxicologist":[147],"application":[150,169],"silibinin":[152,171,214,260],"Amanita":[154],"phalloides":[155],"poisoning.":[156],"Clinical":[157],"trials":[158],"conducted":[159],"respect":[162],"are":[163],"very":[164],"encouraging.":[165],"The":[166,180],"therapy":[174],"alcoholic":[177],"cirrhosis.":[179],"evidence":[181],"shows":[182],"that":[183,235],"use":[185],"silymarin":[187],"leads":[188],"to":[189,255],"significant":[191],"reduction":[192,198],"liver-related":[194],"mortality":[195],"even":[197,227],"number":[201],"patients":[203],"encephalopathy":[205],"course":[208],"disease.":[211],"Application":[212],"goes":[215],"beyond":[216],"disease":[218],"expands":[220],"direction":[223],"cancer":[225],"diabetes.":[228],"What":[229],"fact,":[234],"substance":[237],"herbal":[239],"origin":[240],"occurring":[241],"environment":[244],"so":[246],"strong,":[247],"favorable,":[248],"multidirectional.":[251],"Science":[252],"has":[253],"contributed":[254],"improving":[256],"bioavailability":[258],"thus":[261],"making":[262],"more":[264],"effective.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
