{"id":"https://openalex.org/W2007492445","doi":"https://doi.org/10.1089/ars.2012.5157","title":"A Novel Antihypoglycemic Role of Inducible Nitric Oxide Synthase in Liver Inflammatory Response Induced by Dietary Cholesterol and Endotoxemia","display_name":"A Novel Antihypoglycemic Role of Inducible Nitric Oxide Synthase in Liver Inflammatory Response Induced by Dietary Cholesterol and Endotoxemia","publication_year":2013,"publication_date":"2013-05-23","ids":{"openalex":"https://openalex.org/W2007492445","doi":"https://doi.org/10.1089/ars.2012.5157","mag":"2007492445","pmid":"https://pubmed.ncbi.nlm.nih.gov/23697659","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3852347"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2012.5157","doi":"https://doi.org/10.1089/ars.2012.5157","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2012.5157","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3852347/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058199614","display_name":"Sarit Anavi","orcid":"https://orcid.org/0009-0006-3730-4325","observed_orcids":["https://orcid.org/0009-0006-3730-4325"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sarit Anavi","raw_affiliation_strings":["The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026018862","display_name":"Michal Hahn-Obercyger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Hahn-Obercyger","raw_affiliation_strings":["The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114006953","display_name":"Raanan Margalit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raanan Margalit","raw_affiliation_strings":["Science in Action Ltd., Ness Ziona, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science in Action Ltd., Ness Ziona, Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033813527","display_name":"Zecharia Madar","orcid":"https://orcid.org/0000-0001-6635-8513","observed_orcids":["https://orcid.org/0000-0001-6635-8513"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Zecharia Madar","raw_affiliation_strings":["The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031288153","display_name":"Oren Tirosh","orcid":"https://orcid.org/0000-0001-5407-0440","observed_orcids":["https://orcid.org/0000-0001-5407-0440"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Oren Tirosh","raw_affiliation_strings":["The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031288153"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":null,"apc_paid":null,"fwci":1.4155,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.80213264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"19","issue":"16","first_page":"1889","last_page":"1901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.1648000031709671,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.11779999732971191,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8920000195503235},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glycogenolysis","display_name":"glycogenolysis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6389999985694885},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.5590000152587891},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7562589645385742},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7247220873832703},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7105230093002319},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.573340654373169},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5617325901985168},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.5140300989151001},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5017058849334717},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.4608255624771118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45073381066322327},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.44489210844039917},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43592405319213867},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.42092710733413696},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.4192408621311188},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4104299545288086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31430310010910034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23604369163513184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2114325761795044},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.20980241894721985},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.16574060916900635},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.13543519377708435},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1339995563030243},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11077991127967834},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002791","descriptor_name":"Cholesterol, Dietary","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/ars.2012.5157","doi":"https://doi.org/10.1089/ars.2012.5157","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2012.5157","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},{"id":"pmid:23697659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23697659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3852347","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3852347/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxid Redox Signal","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3852347","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3852347/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxid Redox Signal","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6011857381","display_name":null,"funder_award_id":"371/12","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W34084691","https://openalex.org/W1967972402","https://openalex.org/W1973720695","https://openalex.org/W1976609232","https://openalex.org/W1976806178","https://openalex.org/W1984661645","https://openalex.org/W1988039243","https://openalex.org/W1996775250","https://openalex.org/W1998907758","https://openalex.org/W1999231148","https://openalex.org/W2004229303","https://openalex.org/W2007124833","https://openalex.org/W2007650925","https://openalex.org/W2014694930","https://openalex.org/W2015790556","https://openalex.org/W2027695687","https://openalex.org/W2027881705","https://openalex.org/W2042778710","https://openalex.org/W2047962338","https://openalex.org/W2051488946","https://openalex.org/W2060440665","https://openalex.org/W2060476201","https://openalex.org/W2070053386","https://openalex.org/W2071741172","https://openalex.org/W2072561647","https://openalex.org/W2073438109","https://openalex.org/W2075112224","https://openalex.org/W2098337165","https://openalex.org/W2106778301","https://openalex.org/W2111722779","https://openalex.org/W2113667153","https://openalex.org/W2113795744","https://openalex.org/W2150805660","https://openalex.org/W2151821796","https://openalex.org/W2164778116","https://openalex.org/W2168526937","https://openalex.org/W2170261487","https://openalex.org/W2322050939","https://openalex.org/W2408208453"],"related_works":["https://openalex.org/W1984661645","https://openalex.org/W1963542217","https://openalex.org/W1979171780","https://openalex.org/W2060440665","https://openalex.org/W2531237418","https://openalex.org/W2023574991","https://openalex.org/W2099898722","https://openalex.org/W1970890994","https://openalex.org/W4254993803","https://openalex.org/W2083322721"],"abstract_inverted_index":{"AIMS:":[0],"The":[1,166],"current":[2],"study":[3],"aim":[4],"was":[5,26,78,88,106,118,154,180],"to":[6,59,109,238],"elucidate":[7],"the":[8,43,82,121,197,203,219,229,235,246],"antihypoglycemic":[9],"role":[10,168,231],"and":[11,31,41,63,91,95,126,130,143,191,211,243],"mechanism":[12],"of":[13,45,84,97,123,152,169,199,205,221,232,249],"inducible":[14],"nitric":[15],"oxide":[16],"synthase":[17],"(iNOS)":[18],"under":[19],"inflammatory":[20,24,71],"stress.":[21],"METHODS:":[22],"Liver":[23],"stress":[25,190],"induced":[27],"in":[28,61,74,81,120,157,163,172,183,196,218,234,240],"wild-type":[29],"(WT)":[30],"iNOS-knockout":[32],"(iNOS(-/-))":[33],"mice":[34,135],"by":[35,49,177],"lipopolysaccharide":[36],"(LPS)":[37],"(5":[38],"mg/kg)":[39],"with":[40],"without":[42],"background":[44],"nonalcoholic":[46],"steatohepatitis":[47,60],"(NASH)-Induced":[48],"high":[50],"cholesterol":[51,129],"diet":[52],"(HCD,":[53],"6":[54],"weeks).":[55],"RESULTS:":[56],"HCD":[57],"led":[58],"WT":[62,134],"iNOS(-/-)":[64,101,124,164,200],"mice.":[65,165,201],"LPS":[66,148,239],"administration":[67],"caused":[68],"marked":[69],"liver":[70,132],"damage":[72],"only":[73],"cholesterol-fed":[75],"mice,":[76,125],"which":[77],"further":[79],"exacerbated":[80],"absence":[83,220],"iNOS.":[85,222,250],"Glucose":[86],"homeostasis":[87],"significantly":[89,127,216],"impaired":[90,107],"included":[92],"fatal":[93],"hypoglycemia":[94],"inhibition":[96],"glycogen":[98,145],"decomposition.":[99],"In":[100],"hypoxia-inducible":[102],"factor-1":[103],"(HIF1),":[104],"signaling":[105,171],"compared":[108],"control":[110],"WT.":[111],"Using":[112],"hydrodynamic":[113],"gene":[114],"transfer":[115],"method":[116],"HIF1\u03b1":[117,137,153],"expressed":[119],"livers":[122,198],"ameliorated":[128],"LPS-induced":[131,159],"damage.":[133],"overexpressing":[136],"exhibited":[138],"higher":[139],"blood":[140],"glucose":[141,160,174],"levels":[142],"lower":[144],"contents":[146],"after":[147],"injection.":[149],"Conversely,":[150],"induction":[151],"not":[155],"effective":[156],"preventing":[158],"lowering":[161],"effect":[162],"critical":[167],"NO":[170],"hepatocytes":[173],"output":[175],"mediated":[176],"HIF1":[178],"pathway":[179],"also":[181,186],"confirmed":[182],"vitro.":[184],"Results":[185],"demonstrated":[187],"increased":[188],"oxidative":[189],"reduced":[192],"heme":[193],"oxygenase-1":[194],"mRNA":[195,214],"Furthermore,":[202],"amounts":[204],"plasma":[206],"tumor":[207],"necrosis":[208],"factor-\u03b1":[209],"(TNF\u03b1)":[210],"intrahepatic":[212],"TNF\u03b1":[213],"were":[215],"elevated":[217],"INNOVATION":[223],"AND":[224],"CONCLUSION:":[225],"These":[226],"data":[227],"highlight":[228],"essential":[230],"iNOS":[233],"glycemic":[236],"response":[237],"NASH":[241],"conditions":[242],"argues":[244],"for":[245],"beneficial":[247],"effects":[248]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}