{"id":"https://openalex.org/W2007490970","doi":"https://doi.org/10.1016/j.tiv.2011.06.001","title":"Fine particulate matter from urban ambient and wildfire sources from California\u2019s San Joaquin Valley initiate differential inflammatory, oxidative stress, and xenobiotic responses in human bronchial epithelial cells","display_name":"Fine particulate matter from urban ambient and wildfire sources from California\u2019s San Joaquin Valley initiate differential inflammatory, oxidative stress, and xenobiotic responses in human bronchial epithelial cells","publication_year":2011,"publication_date":"2011-06-25","ids":{"openalex":"https://openalex.org/W2007490970","doi":"https://doi.org/10.1016/j.tiv.2011.06.001","mag":"2007490970","pmid":"https://pubmed.ncbi.nlm.nih.gov/21703343"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2011.06.001","doi":"https://doi.org/10.1016/j.tiv.2011.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2011.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035301969","display_name":"Luann Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.S. Nakayama Wong","raw_affiliation_strings":["School of Veterinary Medicine, Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA 95616, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA 95616, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110485212","display_name":"Hnin Hnin Aung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.H. Aung","raw_affiliation_strings":["School of Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA 95616, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA 95616, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113528055","display_name":"Michael W. Lam\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.W. Lam\u00e9","raw_affiliation_strings":["School of Veterinary Medicine, Department of Molecular Biosciences, University of California, Davis, CA 95616, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Department of Molecular Biosciences, University of California, Davis, CA 95616, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003910019","display_name":"Teresa C. Wegesser","orcid":"https://orcid.org/0000-0002-2024-2280","observed_orcids":["https://orcid.org/0000-0002-2024-2280"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.C. Wegesser","raw_affiliation_strings":["School of Medicine, Department of Pulmonary and Critical Care Medicine, University of California, Davis, CA 95616, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Department of Pulmonary and Critical Care Medicine, University of California, Davis, CA 95616, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103798083","display_name":"Dennis W. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D.W. Wilson","raw_affiliation_strings":["School of Veterinary Medicine, Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA 95616, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA 95616, United States","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103798083"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.5341,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.86115087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"25","issue":"8","first_page":"1895","last_page":"1905"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10075","display_name":"Atmospheric chemistry and aerosols","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1902","display_name":"Atmospheric Science"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pm2-5","display_name":"PM2.5","score":0.9950000047683716},{"id":"https://openalex.org/keywords/wildfire-smoke","display_name":"wildfire smoke","score":0.8349999785423279},{"id":"https://openalex.org/keywords/human-bronchial-epithelial-cells","display_name":"human bronchial epithelial cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9700000286102295},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7419999837875366},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8970000147819519},{"id":"https://openalex.org/keywords/transition-metals","display_name":"transition metals","score":0.9869999885559082},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.968999981880188},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7990000247955322},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/san-joaquin-valley","display_name":"San Joaquin Valley","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.694865882396698},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.6693403124809265},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.510513424873352},{"id":"https://openalex.org/C24245907","wikidata":"https://www.wikidata.org/wiki/Q498957","display_name":"Particulates","level":2,"score":0.5090741515159607},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4254930913448334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3949616551399231},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3775828182697296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18333005905151367},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1103646457195282},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002140","descriptor_name":"California","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002947","descriptor_name":"Cities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005390","descriptor_name":"Fires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052638","descriptor_name":"Particulate Matter","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tiv.2011.06.001","doi":"https://doi.org/10.1016/j.tiv.2011.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2011.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:21703343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21703343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Sustainable cities and communities","id":"https://metadata.un.org/sdg/11"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W156137099","https://openalex.org/W292167830","https://openalex.org/W1497098097","https://openalex.org/W1551392207","https://openalex.org/W1660567315","https://openalex.org/W1935479846","https://openalex.org/W1965013739","https://openalex.org/W1968332094","https://openalex.org/W1970855742","https://openalex.org/W1972004288","https://openalex.org/W1974683051","https://openalex.org/W1975216365","https://openalex.org/W1980090150","https://openalex.org/W1989718033","https://openalex.org/W1997308064","https://openalex.org/W2002300770","https://openalex.org/W2014903037","https://openalex.org/W2024007859","https://openalex.org/W2025662587","https://openalex.org/W2031612481","https://openalex.org/W2032304119","https://openalex.org/W2037016203","https://openalex.org/W2041791106","https://openalex.org/W2045668328","https://openalex.org/W2046440869","https://openalex.org/W2046478419","https://openalex.org/W2052672690","https://openalex.org/W2055188960","https://openalex.org/W2061049779","https://openalex.org/W2068200656","https://openalex.org/W2073149136","https://openalex.org/W2075211725","https://openalex.org/W2077762362","https://openalex.org/W2077811143","https://openalex.org/W2080289585","https://openalex.org/W2081231545","https://openalex.org/W2083784656","https://openalex.org/W2091733516","https://openalex.org/W2092776294","https://openalex.org/W2093585097","https://openalex.org/W2094806430","https://openalex.org/W2103555767","https://openalex.org/W2103583545","https://openalex.org/W2106287633","https://openalex.org/W2107277218","https://openalex.org/W2108279087","https://openalex.org/W2109078794","https://openalex.org/W2109865874","https://openalex.org/W2114477244","https://openalex.org/W2114585886","https://openalex.org/W2116522708","https://openalex.org/W2121318947","https://openalex.org/W2124617998","https://openalex.org/W2129277308","https://openalex.org/W2131997042","https://openalex.org/W2139599767","https://openalex.org/W2143127434","https://openalex.org/W2144541431","https://openalex.org/W2147173407","https://openalex.org/W2156960522","https://openalex.org/W2157043675","https://openalex.org/W2161928149","https://openalex.org/W2167534706","https://openalex.org/W2171456038","https://openalex.org/W2329051861","https://openalex.org/W4405989271","https://openalex.org/W6637119934"],"related_works":["https://openalex.org/W7141778054","https://openalex.org/W3106108271","https://openalex.org/W2166899266","https://openalex.org/W2042999701","https://openalex.org/W2952931346","https://openalex.org/W2076649440","https://openalex.org/W2904348429","https://openalex.org/W1663120187","https://openalex.org/W2334972472","https://openalex.org/W2889789371"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}