{"id":"https://openalex.org/W2007486805","doi":"https://doi.org/10.1126/science.1056843","title":"Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2","display_name":"Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2","publication_year":2001,"publication_date":"2001-03-30","ids":{"openalex":"https://openalex.org/W2007486805","doi":"https://doi.org/10.1126/science.1056843","mag":"2007486805","pmid":"https://pubmed.ncbi.nlm.nih.gov/11283375"},"language":"en","primary_location":{"id":"doi:10.1126/science.1056843","doi":"https://doi.org/10.1126/science.1056843","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1056843","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015517881","display_name":"Lutfi A. Abu-Elheiga","orcid":"https://orcid.org/0000-0002-7366-3556","observed_orcids":["https://orcid.org/0000-0002-7366-3556"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lutfi Abu-Elheiga","raw_affiliation_strings":["Verna and Marrs McLean Department of Biochemistry and Molecular Biology and","Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology and","institution_ids":[]},{"raw_affiliation_string":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050632280","display_name":"Martin Matthew Matzuk","orcid":"https://orcid.org/0000-0002-1445-8632","observed_orcids":["https://orcid.org/0000-0002-1445-8632"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin M. Matzuk","raw_affiliation_strings":["Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039918549","display_name":"Khaled A.H. Abo-Hashema","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khaled A. H. Abo-Hashema","raw_affiliation_strings":["Verna and Marrs McLean Department of Biochemistry and Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085224645","display_name":"Salih J. Wakil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Salih J. Wakil","raw_affiliation_strings":["Verna and Marrs McLean Department of Biochemistry and Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085224645"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.8627,"has_fulltext":false,"cited_by_count":902,"citation_normalized_percentile":{"value":0.99532374,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"291","issue":"5513","first_page":"2613","last_page":"2616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.24799999594688416,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.10520000010728836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase-2","display_name":"acetyl-CoA carboxylase 2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/malonyl-coa","display_name":"malonyl-CoA","score":0.9139999747276306},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.996999979019165},{"id":"https://openalex.org/keywords/fat-deposition","display_name":"fat deposition","score":0.9319999814033508},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8500000238418579},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.7580000162124634},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.43700000643730164},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/fat-loss","display_name":"fat loss","score":0.5350000262260437},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.4480000138282776},{"id":"https://openalex.org/keywords/muscle","display_name":"muscle","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.7425860166549683},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.7320352792739868},{"id":"https://openalex.org/C2779318131","wikidata":"https://www.wikidata.org/wiki/Q21199067","display_name":"Acetyl-CoA carboxylase","level":4,"score":0.7254139184951782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6359198093414307},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.628892719745636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.614661693572998},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5523138046264648},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5422966480255127},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4782787263393402},{"id":"https://openalex.org/C2779364145","wikidata":"https://www.wikidata.org/wiki/Q27095293","display_name":"Malonyl-CoA","level":4,"score":0.4702792465686798},{"id":"https://openalex.org/C2776941171","wikidata":"https://www.wikidata.org/wiki/Q900209","display_name":"Fatty acid synthesis","level":3,"score":0.4632270336151123},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.43898648023605347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4126424789428711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2457384467124939},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1288774013519287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06245735287666321},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008112","descriptor_name":"Liver Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008112","descriptor_name":"Liver Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008112","descriptor_name":"Liver Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008316","descriptor_name":"Malonyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008316","descriptor_name":"Malonyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008316","descriptor_name":"Malonyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020155","descriptor_name":"3-Hydroxybutyric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020155","descriptor_name":"3-Hydroxybutyric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020155","descriptor_name":"3-Hydroxybutyric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1056843","doi":"https://doi.org/10.1126/science.1056843","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1056843","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:11283375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11283375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.550000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4346765716","display_name":null,"funder_award_id":"GM19091","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W131343593","https://openalex.org/W315175669","https://openalex.org/W1523351848","https://openalex.org/W1556524613","https://openalex.org/W1564338477","https://openalex.org/W1569859724","https://openalex.org/W1577348758","https://openalex.org/W1607894141","https://openalex.org/W1964122705","https://openalex.org/W1964606633","https://openalex.org/W1968261837","https://openalex.org/W1971620692","https://openalex.org/W1982126966","https://openalex.org/W1996713062","https://openalex.org/W2017627482","https://openalex.org/W2031846075","https://openalex.org/W2039167216","https://openalex.org/W2042033533","https://openalex.org/W2042764090","https://openalex.org/W2058516725","https://openalex.org/W2059533405","https://openalex.org/W2066638103","https://openalex.org/W2077688724","https://openalex.org/W2123955594","https://openalex.org/W2126909426","https://openalex.org/W2127101467","https://openalex.org/W2130755410","https://openalex.org/W2154555913","https://openalex.org/W2169424788","https://openalex.org/W2170155462","https://openalex.org/W2263966455","https://openalex.org/W2419043872","https://openalex.org/W2589546348","https://openalex.org/W2764835254","https://openalex.org/W4241536272"],"related_works":["https://openalex.org/W2411755710","https://openalex.org/W2062656152","https://openalex.org/W1988092776","https://openalex.org/W2159553300","https://openalex.org/W1978755855","https://openalex.org/W1979736292","https://openalex.org/W2016418884","https://openalex.org/W2050470837","https://openalex.org/W2903987168","https://openalex.org/W2052566044"],"abstract_inverted_index":{"Malonyl-coenzyme":[0],"A":[1],"(malonyl-CoA),":[2],"generated":[3],"by":[4,89,105],"acetyl-CoA":[5],"carboxylases":[6],"ACC1":[7],"and":[8,38,53,61,85],"ACC2,":[9],"is":[10],"a":[11,28,32],"key":[12],"metabolite":[13],"in":[14,59,69,114,139],"the":[15,46,70,74,98,125,140],"regulation":[16],"of":[17,41,57,73,82,91,95,130,136,142],"energy":[18],"homeostasis.":[19],"Here,":[20],"we":[21],"show":[22],"that":[23,81,127],"Acc2-/-":[24,75],"mutant":[25,108],"mice":[26,50,76,84,109],"have":[27],"normal":[29,143],"life":[30],"span,":[31],"higher":[33,79],"fatty":[34,65,102],"acid":[35,66,103],"oxidation":[36,67,104],"rate,":[37],"lower":[39,55],"amounts":[40],"fat.":[42],"In":[43],"comparison":[44],"to":[45,97,134],"wild":[47],"type,":[48],"Acc2-deficient":[49],"had":[51],"10-":[52],"30-fold":[54],"levels":[56],"malonyl-CoA":[58],"heart":[60],"muscle,":[62],"respectively.":[63],"The":[64,107],"rate":[68],"soleus":[71],"muscle":[72,100],"was":[77,86],"30%":[78],"than":[80,118],"wild-type":[83,99,120],"not":[87],"affected":[88],"addition":[90,94],"insulin;":[92],"however,":[93],"insulin":[96],"reduced":[101],"45%.":[106],"accumulated":[110],"50%":[111],"less":[112],"fat":[113,138],"their":[115],"adipose":[116],"tissue":[117],"did":[119],"mice.":[121],"These":[122],"results":[123],"raise":[124],"possibility":[126],"pharmacological":[128],"manipulation":[129],"ACC2":[131],"may":[132],"lead":[133],"loss":[135],"body":[137],"context":[141],"caloric":[144],"intake.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":36},{"year":2017,"cited_by_count":33},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":50},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":38},{"year":2012,"cited_by_count":43}],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2025-10-10T00:00:00"}
